FLASH assembly of TALENs for high-throughput genome editing

Transcription activator–like effector nucleases (TALENs) enable genetic modification at specific sites in a genome. Reyon et al . present a method for high-throughput generation of TALENs, facilitating large-scale genome engineering. Engineered transcription activator–like effector nucleases (TALENs...

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Veröffentlicht in:	Nature biotechnology 2012-05, Vol.30 (5), p.460-465
Hauptverfasser:	Reyon, Deepak, Tsai, Shengdar Q, Khayter, Cyd, Foden, Jennifer A, Sander, Jeffry D, Joung, J Keith
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/1511 631/337 631/61/338 631/61/51/2316 Agriculture Automation Base Sequence Binding sites Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical engineering Biomedical Engineering/Biotechnology Biomedicine Biotechnology Biotinylation Computational Biology - methods Diverse techniques DNA binding proteins DNA Restriction Enzymes - genetics Endonucleases - genetics Epigenesis, Genetic Fundamental and applied biological sciences. Psychology Gene Targeting - methods Genetic Techniques Genetic transcription Genome, Human Genomics Green Fluorescent Proteins - metabolism Humans Life Sciences Molecular and cellular biology Molecular Sequence Data Mutation Neoplasms - genetics Nucleases Physiological aspects Proteins resource Sequence Analysis, DNA - instrumentation Sequence Analysis, DNA - methods Sequence Homology, Nucleic Acid Transcription, Genetic
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