A low-invasive and effective transcutaneous immunization system using a novel dissolving microneedle array for soluble and particulate antigens

Transcutaneous immunization (TCI) is a promising needle-free, easy-to-use, and low-invasive vaccination method. The hydrogel patch-based TCI system induced immune responses against soluble antigens (Ags) like toxoids, but could not induce immune responses against particulate Ags. Here, as an effecti...

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Veröffentlicht in:	Journal of controlled release 2012-07, Vol.161 (1), p.10-17
Hauptverfasser:	Matsuo, Kazuhiko, Yokota, Yayoi, Zhai, You, Quan, Ying-Shu, Kamiyama, Fumio, Mukai, Yohei, Okada, Naoki, Nakagawa, Shinsaku
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - immunology Adenoviridae Infections - prevention & control Administration, Cutaneous Animals antigens Antigens - administration & dosage Antigens - immunology Biological and medical sciences Cell Line Dissolving microneedle array Drug Delivery Systems - instrumentation Female General pharmacology Humans Hyaluronic Acid - chemistry hydrocolloids immune response Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Ovalbumin - immunology Particulate antigen Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Rats Rats, Wistar Skin Skin - metabolism skin irritation Soluble antigen toxoids Transcutaneous immunization Transdermal Patch vaccination Vaccination - instrumentation Vaccine vaccines
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