Right ventricular dysfunction in adolescents with mild cystic fibrosis
Abstract Background In cystic fibrosis (CF) patients the right ventricle (RV) suffers a progressive deterioration, but it is not clear when these changes begin. The aim of this study was to analyze the RV function in CF patients with mild respiratory disease. Methods Color-Doppler-Echocardiographic...
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| Veröffentlicht in: | Journal of cystic fibrosis 2012-07, Vol.11 (4), p.274-280 |
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| creator | Baño-Rodrigo, Antonio Salcedo-Posadas, Antonio Villa-Asensi, Jose R Tamariz-Martel, Amalia Lopez-Neyra, Alejandro Blanco-Iglesias, Elena |
| description | Abstract Background In cystic fibrosis (CF) patients the right ventricle (RV) suffers a progressive deterioration, but it is not clear when these changes begin. The aim of this study was to analyze the RV function in CF patients with mild respiratory disease. Methods Color-Doppler-Echocardiographic studies were prospectively performed in CF adolescent patients and an age-matched control group. Findings were correlated with pulmonary function tests (PFT), genotype, chronic bacterial colonization, pancreatic status and clinical scores. Only patients with mild CF were selected. Results Thirty seven CF patients and 40 healthy controls were recruited. In CF patients all echocardiographic parameters were abnormal compared to controls. Doppler analysis showed slightly elevated pulmonary artery pressure values, and abnormal relaxation and systolic function for all indexes. No correlation was found with any of the features studied. Conclusions In CF patients, abnormalities in the structure and function of the RV may be present at early stages of the disease. These abnormalities are subclinical and do not correlate with clinical scores, PFT, genotype, chronic bacterial colonization or pancreatic insufficiency. |
| doi_str_mv | 10.1016/j.jcf.2012.03.002 |
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The aim of this study was to analyze the RV function in CF patients with mild respiratory disease. Methods Color-Doppler-Echocardiographic studies were prospectively performed in CF adolescent patients and an age-matched control group. Findings were correlated with pulmonary function tests (PFT), genotype, chronic bacterial colonization, pancreatic status and clinical scores. Only patients with mild CF were selected. Results Thirty seven CF patients and 40 healthy controls were recruited. In CF patients all echocardiographic parameters were abnormal compared to controls. Doppler analysis showed slightly elevated pulmonary artery pressure values, and abnormal relaxation and systolic function for all indexes. No correlation was found with any of the features studied. Conclusions In CF patients, abnormalities in the structure and function of the RV may be present at early stages of the disease. These abnormalities are subclinical and do not correlate with clinical scores, PFT, genotype, chronic bacterial colonization or pancreatic insufficiency.</description><identifier>ISSN: 1569-1993</identifier><identifier>EISSN: 1873-5010</identifier><identifier>DOI: 10.1016/j.jcf.2012.03.002</identifier><identifier>PMID: 22483972</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adolescent ; Child ; Cystic fibrosis ; Cystic Fibrosis - complications ; Cystic Fibrosis - genetics ; Cystic Fibrosis Transmembrane Conductance Regulator - genetics ; Echocardiography ; Echocardiography, Doppler, Color ; Female ; Genotype ; Heart Ventricles - pathology ; Heart Ventricles - physiopathology ; Humans ; Male ; Myocardial Contraction - physiology ; Prospective Studies ; Pulmonary Heart Disease - diagnostic imaging ; Pulmonary Heart Disease - etiology ; Pulmonary Heart Disease - physiopathology ; Pulmonary/Respiratory ; Respiratory Function Tests ; Right ventricular function ; Severity of Illness Index ; Tricuspid Valve - physiology ; Ventricular Dysfunction, Right - diagnostic imaging ; Ventricular Dysfunction, Right - etiology ; Ventricular Dysfunction, Right - physiopathology</subject><ispartof>Journal of cystic fibrosis, 2012-07, Vol.11 (4), p.274-280</ispartof><rights>European Cystic Fibrosis Society.</rights><rights>2012 European Cystic Fibrosis Society.</rights><rights>Copyright © 2012 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-8efe6b917cbf6e61e04c9e8679852f4300cd7d2ccabb2e9548ada9644b63a87d3</citedby><cites>FETCH-LOGICAL-c451t-8efe6b917cbf6e61e04c9e8679852f4300cd7d2ccabb2e9548ada9644b63a87d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jcf.2012.03.002$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22483972$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baño-Rodrigo, Antonio</creatorcontrib><creatorcontrib>Salcedo-Posadas, Antonio</creatorcontrib><creatorcontrib>Villa-Asensi, Jose R</creatorcontrib><creatorcontrib>Tamariz-Martel, Amalia</creatorcontrib><creatorcontrib>Lopez-Neyra, Alejandro</creatorcontrib><creatorcontrib>Blanco-Iglesias, Elena</creatorcontrib><title>Right ventricular dysfunction in adolescents with mild cystic fibrosis</title><title>Journal of cystic fibrosis</title><addtitle>J Cyst Fibros</addtitle><description>Abstract Background In cystic fibrosis (CF) patients the right ventricle (RV) suffers a progressive deterioration, but it is not clear when these changes begin. The aim of this study was to analyze the RV function in CF patients with mild respiratory disease. Methods Color-Doppler-Echocardiographic studies were prospectively performed in CF adolescent patients and an age-matched control group. Findings were correlated with pulmonary function tests (PFT), genotype, chronic bacterial colonization, pancreatic status and clinical scores. Only patients with mild CF were selected. Results Thirty seven CF patients and 40 healthy controls were recruited. In CF patients all echocardiographic parameters were abnormal compared to controls. Doppler analysis showed slightly elevated pulmonary artery pressure values, and abnormal relaxation and systolic function for all indexes. No correlation was found with any of the features studied. Conclusions In CF patients, abnormalities in the structure and function of the RV may be present at early stages of the disease. These abnormalities are subclinical and do not correlate with clinical scores, PFT, genotype, chronic bacterial colonization or pancreatic insufficiency.</description><subject>Adolescent</subject><subject>Child</subject><subject>Cystic fibrosis</subject><subject>Cystic Fibrosis - complications</subject><subject>Cystic Fibrosis - genetics</subject><subject>Cystic Fibrosis Transmembrane Conductance Regulator - genetics</subject><subject>Echocardiography</subject><subject>Echocardiography, Doppler, Color</subject><subject>Female</subject><subject>Genotype</subject><subject>Heart Ventricles - pathology</subject><subject>Heart Ventricles - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Myocardial Contraction - physiology</subject><subject>Prospective Studies</subject><subject>Pulmonary Heart Disease - diagnostic imaging</subject><subject>Pulmonary Heart Disease - etiology</subject><subject>Pulmonary Heart Disease - physiopathology</subject><subject>Pulmonary/Respiratory</subject><subject>Respiratory Function Tests</subject><subject>Right ventricular function</subject><subject>Severity of Illness Index</subject><subject>Tricuspid Valve - physiology</subject><subject>Ventricular Dysfunction, Right - diagnostic imaging</subject><subject>Ventricular Dysfunction, Right - etiology</subject><subject>Ventricular Dysfunction, Right - physiopathology</subject><issn>1569-1993</issn><issn>1873-5010</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1q3TAQRkVpadK0D5BN8LIbuyPJtiQChRKatBAo5Gct5NE4keNrp5Kdct8-utykiy660izO9zE6w9gxh4oDb78M1YB9JYCLCmQFIN6wQ66VLBvg8DbPTWtKbow8YB9SGgC4AqXfswMhai2NEofs_Crc3S_FE01LDLiOLhZ-m_p1wiXMUxGmwvl5pIQZSMWfsNwXmzD6ArdpCVj0oYtzCukje9e7MdGnl_eI3Z5_vzn7UV7-uvh59u2yxLrhS6mpp7YzXGHXt9RyghoN6VYZ3Yi-lgDolReIrusEmabWzjvT1nXXSqeVl0fs8773Mc6_V0qL3YS82zi6ieY1WQ6Ci0YZqTPK9yjmDVOk3j7GsHFxmyG702cHm_XZnT4L0mZ9OXPyUr92G_J_E6--MnC6Byh_8ilQtAkDTUg-RMLF-jn8t_7rP2kcwxTQjQ-0pTTMa5yyPcttyhl7vbvf7nxcAEDNQT4D59-Vnw</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>Baño-Rodrigo, Antonio</creator><creator>Salcedo-Posadas, Antonio</creator><creator>Villa-Asensi, Jose R</creator><creator>Tamariz-Martel, Amalia</creator><creator>Lopez-Neyra, Alejandro</creator><creator>Blanco-Iglesias, Elena</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120701</creationdate><title>Right ventricular dysfunction in adolescents with mild cystic fibrosis</title><author>Baño-Rodrigo, Antonio ; Salcedo-Posadas, Antonio ; Villa-Asensi, Jose R ; Tamariz-Martel, Amalia ; Lopez-Neyra, Alejandro ; Blanco-Iglesias, Elena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-8efe6b917cbf6e61e04c9e8679852f4300cd7d2ccabb2e9548ada9644b63a87d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Cystic fibrosis</topic><topic>Cystic Fibrosis - complications</topic><topic>Cystic Fibrosis - genetics</topic><topic>Cystic Fibrosis Transmembrane Conductance Regulator - genetics</topic><topic>Echocardiography</topic><topic>Echocardiography, Doppler, Color</topic><topic>Female</topic><topic>Genotype</topic><topic>Heart Ventricles - pathology</topic><topic>Heart Ventricles - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Myocardial Contraction - physiology</topic><topic>Prospective Studies</topic><topic>Pulmonary Heart Disease - diagnostic imaging</topic><topic>Pulmonary Heart Disease - etiology</topic><topic>Pulmonary Heart Disease - physiopathology</topic><topic>Pulmonary/Respiratory</topic><topic>Respiratory Function Tests</topic><topic>Right ventricular function</topic><topic>Severity of Illness Index</topic><topic>Tricuspid Valve - physiology</topic><topic>Ventricular Dysfunction, Right - diagnostic imaging</topic><topic>Ventricular Dysfunction, Right - etiology</topic><topic>Ventricular Dysfunction, Right - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baño-Rodrigo, Antonio</creatorcontrib><creatorcontrib>Salcedo-Posadas, Antonio</creatorcontrib><creatorcontrib>Villa-Asensi, Jose R</creatorcontrib><creatorcontrib>Tamariz-Martel, Amalia</creatorcontrib><creatorcontrib>Lopez-Neyra, Alejandro</creatorcontrib><creatorcontrib>Blanco-Iglesias, Elena</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cystic fibrosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baño-Rodrigo, Antonio</au><au>Salcedo-Posadas, Antonio</au><au>Villa-Asensi, Jose R</au><au>Tamariz-Martel, Amalia</au><au>Lopez-Neyra, Alejandro</au><au>Blanco-Iglesias, Elena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Right ventricular dysfunction in adolescents with mild cystic fibrosis</atitle><jtitle>Journal of cystic fibrosis</jtitle><addtitle>J Cyst Fibros</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>11</volume><issue>4</issue><spage>274</spage><epage>280</epage><pages>274-280</pages><issn>1569-1993</issn><eissn>1873-5010</eissn><abstract>Abstract Background In cystic fibrosis (CF) patients the right ventricle (RV) suffers a progressive deterioration, but it is not clear when these changes begin. The aim of this study was to analyze the RV function in CF patients with mild respiratory disease. Methods Color-Doppler-Echocardiographic studies were prospectively performed in CF adolescent patients and an age-matched control group. Findings were correlated with pulmonary function tests (PFT), genotype, chronic bacterial colonization, pancreatic status and clinical scores. Only patients with mild CF were selected. Results Thirty seven CF patients and 40 healthy controls were recruited. In CF patients all echocardiographic parameters were abnormal compared to controls. Doppler analysis showed slightly elevated pulmonary artery pressure values, and abnormal relaxation and systolic function for all indexes. No correlation was found with any of the features studied. Conclusions In CF patients, abnormalities in the structure and function of the RV may be present at early stages of the disease. These abnormalities are subclinical and do not correlate with clinical scores, PFT, genotype, chronic bacterial colonization or pancreatic insufficiency.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>22483972</pmid><doi>10.1016/j.jcf.2012.03.002</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via ScienceDirect (Elsevier) |
| subjects | Adolescent Child Cystic fibrosis Cystic Fibrosis - complications Cystic Fibrosis - genetics Cystic Fibrosis Transmembrane Conductance Regulator - genetics Echocardiography Echocardiography, Doppler, Color Female Genotype Heart Ventricles - pathology Heart Ventricles - physiopathology Humans Male Myocardial Contraction - physiology Prospective Studies Pulmonary Heart Disease - diagnostic imaging Pulmonary Heart Disease - etiology Pulmonary Heart Disease - physiopathology Pulmonary/Respiratory Respiratory Function Tests Right ventricular function Severity of Illness Index Tricuspid Valve - physiology Ventricular Dysfunction, Right - diagnostic imaging Ventricular Dysfunction, Right - etiology Ventricular Dysfunction, Right - physiopathology |
| title | Right ventricular dysfunction in adolescents with mild cystic fibrosis |
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