Foxp3+CD25(high) CD4+ regulatory T cells from indeterminate patients with Chagas disease can suppress the effector cells and cytokines and reveal altered correlations with disease severity

Immunoregulatory mechanisms are important to control the intense immune activity induced in Chagas disease. We evaluated the phenotypic profile and the mechanisms by which Treg cells function in patients with the indeterminate (IND) and cardiac (CARD) clinical forms of Chagas disease. The frequency...

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Veröffentlicht in:	Immunobiology (1979) 2012-08, Vol.217 (8), p.768-777
Hauptverfasser:	de Araújo, F F, Corrêa-Oliveira, R, Rocha, M O C, Chaves, A T, Fiuza, J A, Fares, R C G, Ferreira, K S, Nunes, M C P, Keesen, T S, Damasio, M P S, Teixeira-Carvalho, A, Gomes, J A S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Cell Proliferation Cells, Cultured Chagas Disease - immunology Chagas Disease - metabolism Chagas Disease - parasitology CTLA-4 Antigen - immunology CTLA-4 Antigen - metabolism Cytokines - immunology Cytokines - metabolism Echocardiography Flow Cytometry Forkhead Transcription Factors - immunology Forkhead Transcription Factors - metabolism Heart Function Tests Humans Interferon-gamma - immunology Interferon-gamma - metabolism Interleukin-10 - immunology Interleukin-10 - metabolism Interleukin-17 - immunology Interleukin-17 - metabolism Interleukin-2 Receptor alpha Subunit - immunology Interleukin-2 Receptor alpha Subunit - metabolism Interleukin-6 - immunology Interleukin-6 - metabolism Lymphocyte Count Middle Aged Severity of Illness Index T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Trypanosoma cruzi - immunology Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - metabolism
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