Arterial Stiffness Is Associated With Increased Monocyte Expression of Adiponectin Receptor mRNA and Protein in Patients With Coronary Artery Disease
Background Arterial stiffness and carotid intima-media thickness (IMT) constitute validated cardiovascular prognostic markers. Adiponectin and its receptors 1 (AdipoR1) and 2 (AdipoR2) are involved in coronary artery disease (CAD). We investigated whether AdipoR1 and R2 mRNA and protein expression a...
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| Veröffentlicht in: | American journal of hypertension 2012-07, Vol.25 (7), p.746-755 |
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| creator | Ikonomidis, Ignatios Kadoglou, Nikolaos Tsiotra, Panayoula C. Kollias, Anastasios Palios, Ioannis Fountoulaki, Katerina Halvatsiotis, Iosif Maratou, Eirini Dimitriadis, George Kremastinos, Dimitrios T. Lekakis, John Raptis, Sotirios A. |
| description | Background
Arterial stiffness and carotid intima-media thickness (IMT) constitute validated cardiovascular prognostic markers. Adiponectin and its receptors 1 (AdipoR1) and 2 (AdipoR2) are involved in coronary artery disease (CAD). We investigated whether AdipoR1 and R2 mRNA and protein expression are associated with arterial stiffness, IMT and extent of coronary atherosclerosis.
Methods
We studied 71 patients (61 men, 10 women) with angiographically proven CAD. We measured: (i) monocyte expression of AdipoR1 and AdipoR2 mRNA (quantitative real-time PCR) and protein expression (flow cytometry) (iii) adiponectin, metalloproteinase-9 (MMP-9) and C-reactive protein (CRP) blood levels, (iv) carotid-femoral artery pulse wave velocity (PWV) and carotid IMT.
Results
Patients with multi-vessel CAD had higher AdipoR1 and AdipoR2 mRNA than those with single-vessel (P < 0.05). PWV was associated with AdipoR1 mRNA (r = 0.474), AdipoR1 protein (r = 0.228), AdipoR2 mRNA (r = 0.716), AdipoR2-protein (r = 0.261), adiponectin (r = 0.236), and MMP-9 (r = 0.350) (P < 0.05, for all correlations). After adjustment for age, sex, waist-hip ratio, and mean blood pressure both AdipoR1 and AdipoR2 mRNA remained independent determinants of PWV (R
2 = 0.35 and R
2 = 0.57, P < 0.05). IMT was also associated with AdipoR2 mRNA, AdipoR2 protein, and MMP-9 (P < 0.05). Increased expression of ADR2 mRNA significantly related to MMP-9 (r = 0.210), and CRP (r = 0.531) (P < 0.05).
Conclusion
Increased mRNA and protein expression of adiponectin receptors is related with increased aortic stiffness, coronary and peripheral atherosclerosis in patients with CAD. The interrelation of AdipoR2 with inflammatory markers, PWV and IMT suggests a compensatory increase of these receptors to counteract the excess inflammatory and atherogenic process in CAD. Thus, adiponectin receptors may provide a potential therapeutic target of agents activating their beneficial action. |
| doi_str_mv | 10.1038/ajh.2012.42 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1021257309</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1038/ajh.2012.42</oup_id><sourcerecordid>2689919841</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-5fe38e0311084c49bffdee6e8ba164b58b2593b16de6d4c0dec0f92c52c9a3fb3</originalsourceid><addsrcrecordid>eNp90V2LEzEUBuAgiltXr7yXgCiCTM13Zy6Humph1WVVvBwymRM2ZZrMJhmwP8T_a7qtCl4IgRDOw8k5vAg9pWRJCa_f6O3NkhHKloLdQwvaCFqtGJP30YLUjaxWRNEz9CilLSFEKEUforNS5mLV8AX62cYM0ekRf8nOWg8p4U3CbUrBOJ1hwN9dvsEbbyLoVJ4fgw9mnwFf_Jhi0S54HCxuBzcFDyY7j6_BwJRDxLvrTy3WfsBXMWQolXKudHbgczr2XYcYvI57fDfGHr916fDNY_TA6jHBk9N9jr69u_i6_lBdfn6_WbeXlRFU5kpa4DUQTimphRFNb-0AoKDuNVWil3XPZMN7qgZQgzBkAENsw4xkptHc9vwcvTr2nWK4nSHlbueSgXHUHsKcOkoYZXLFSVPo83_oNszRl-kOitRKSaWKen1UJoaUIthuim5XFiyoO6TVlbS6Q1qdYEU_O_Wc-x0Mf-zveAp4cQI6GT3aqL1x6a9TZW92N9zLowvz9N8ffwE0WqrB</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1020866566</pqid></control><display><type>article</type><title>Arterial Stiffness Is Associated With Increased Monocyte Expression of Adiponectin Receptor mRNA and Protein in Patients With Coronary Artery Disease</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Ikonomidis, Ignatios ; Kadoglou, Nikolaos ; Tsiotra, Panayoula C. ; Kollias, Anastasios ; Palios, Ioannis ; Fountoulaki, Katerina ; Halvatsiotis, Iosif ; Maratou, Eirini ; Dimitriadis, George ; Kremastinos, Dimitrios T. ; Lekakis, John ; Raptis, Sotirios A.</creator><creatorcontrib>Ikonomidis, Ignatios ; Kadoglou, Nikolaos ; Tsiotra, Panayoula C. ; Kollias, Anastasios ; Palios, Ioannis ; Fountoulaki, Katerina ; Halvatsiotis, Iosif ; Maratou, Eirini ; Dimitriadis, George ; Kremastinos, Dimitrios T. ; Lekakis, John ; Raptis, Sotirios A.</creatorcontrib><description>Background
Arterial stiffness and carotid intima-media thickness (IMT) constitute validated cardiovascular prognostic markers. Adiponectin and its receptors 1 (AdipoR1) and 2 (AdipoR2) are involved in coronary artery disease (CAD). We investigated whether AdipoR1 and R2 mRNA and protein expression are associated with arterial stiffness, IMT and extent of coronary atherosclerosis.
Methods
We studied 71 patients (61 men, 10 women) with angiographically proven CAD. We measured: (i) monocyte expression of AdipoR1 and AdipoR2 mRNA (quantitative real-time PCR) and protein expression (flow cytometry) (iii) adiponectin, metalloproteinase-9 (MMP-9) and C-reactive protein (CRP) blood levels, (iv) carotid-femoral artery pulse wave velocity (PWV) and carotid IMT.
Results
Patients with multi-vessel CAD had higher AdipoR1 and AdipoR2 mRNA than those with single-vessel (P < 0.05). PWV was associated with AdipoR1 mRNA (r = 0.474), AdipoR1 protein (r = 0.228), AdipoR2 mRNA (r = 0.716), AdipoR2-protein (r = 0.261), adiponectin (r = 0.236), and MMP-9 (r = 0.350) (P < 0.05, for all correlations). After adjustment for age, sex, waist-hip ratio, and mean blood pressure both AdipoR1 and AdipoR2 mRNA remained independent determinants of PWV (R
2 = 0.35 and R
2 = 0.57, P < 0.05). IMT was also associated with AdipoR2 mRNA, AdipoR2 protein, and MMP-9 (P < 0.05). Increased expression of ADR2 mRNA significantly related to MMP-9 (r = 0.210), and CRP (r = 0.531) (P < 0.05).
Conclusion
Increased mRNA and protein expression of adiponectin receptors is related with increased aortic stiffness, coronary and peripheral atherosclerosis in patients with CAD. The interrelation of AdipoR2 with inflammatory markers, PWV and IMT suggests a compensatory increase of these receptors to counteract the excess inflammatory and atherogenic process in CAD. Thus, adiponectin receptors may provide a potential therapeutic target of agents activating their beneficial action.</description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1941-7225</identifier><identifier>EISSN: 1879-1905</identifier><identifier>DOI: 10.1038/ajh.2012.42</identifier><identifier>PMID: 22534793</identifier><identifier>CODEN: AJHYE6</identifier><language>eng</language><publisher>Basingstoke: Oxford University Press</publisher><subject>Adiponectin - blood ; Aged ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; C-Reactive Protein - metabolism ; Cardiology. Vascular system ; Carotid Intima-Media Thickness ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Coronary Artery Disease - physiopathology ; Cross-Sectional Studies ; Diagnostic Techniques, Cardiovascular ; Female ; Humans ; Male ; Matrix Metalloproteinase 9 - blood ; Medical sciences ; Middle Aged ; Monocytes - metabolism ; Receptors, Adiponectin - genetics ; RNA, Messenger - metabolism ; Vascular Stiffness ; Waist-Hip Ratio</subject><ispartof>American journal of hypertension, 2012-07, Vol.25 (7), p.746-755</ispartof><rights>American Journal of Hypertension, Ltd. © 2012 by the American Journal of Hypertension, Ltd. 2012</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Jul 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-5fe38e0311084c49bffdee6e8ba164b58b2593b16de6d4c0dec0f92c52c9a3fb3</citedby><cites>FETCH-LOGICAL-c415t-5fe38e0311084c49bffdee6e8ba164b58b2593b16de6d4c0dec0f92c52c9a3fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26084209$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22534793$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ikonomidis, Ignatios</creatorcontrib><creatorcontrib>Kadoglou, Nikolaos</creatorcontrib><creatorcontrib>Tsiotra, Panayoula C.</creatorcontrib><creatorcontrib>Kollias, Anastasios</creatorcontrib><creatorcontrib>Palios, Ioannis</creatorcontrib><creatorcontrib>Fountoulaki, Katerina</creatorcontrib><creatorcontrib>Halvatsiotis, Iosif</creatorcontrib><creatorcontrib>Maratou, Eirini</creatorcontrib><creatorcontrib>Dimitriadis, George</creatorcontrib><creatorcontrib>Kremastinos, Dimitrios T.</creatorcontrib><creatorcontrib>Lekakis, John</creatorcontrib><creatorcontrib>Raptis, Sotirios A.</creatorcontrib><title>Arterial Stiffness Is Associated With Increased Monocyte Expression of Adiponectin Receptor mRNA and Protein in Patients With Coronary Artery Disease</title><title>American journal of hypertension</title><addtitle>Am J Hypertens</addtitle><description>Background
Arterial stiffness and carotid intima-media thickness (IMT) constitute validated cardiovascular prognostic markers. Adiponectin and its receptors 1 (AdipoR1) and 2 (AdipoR2) are involved in coronary artery disease (CAD). We investigated whether AdipoR1 and R2 mRNA and protein expression are associated with arterial stiffness, IMT and extent of coronary atherosclerosis.
Methods
We studied 71 patients (61 men, 10 women) with angiographically proven CAD. We measured: (i) monocyte expression of AdipoR1 and AdipoR2 mRNA (quantitative real-time PCR) and protein expression (flow cytometry) (iii) adiponectin, metalloproteinase-9 (MMP-9) and C-reactive protein (CRP) blood levels, (iv) carotid-femoral artery pulse wave velocity (PWV) and carotid IMT.
Results
Patients with multi-vessel CAD had higher AdipoR1 and AdipoR2 mRNA than those with single-vessel (P < 0.05). PWV was associated with AdipoR1 mRNA (r = 0.474), AdipoR1 protein (r = 0.228), AdipoR2 mRNA (r = 0.716), AdipoR2-protein (r = 0.261), adiponectin (r = 0.236), and MMP-9 (r = 0.350) (P < 0.05, for all correlations). After adjustment for age, sex, waist-hip ratio, and mean blood pressure both AdipoR1 and AdipoR2 mRNA remained independent determinants of PWV (R
2 = 0.35 and R
2 = 0.57, P < 0.05). IMT was also associated with AdipoR2 mRNA, AdipoR2 protein, and MMP-9 (P < 0.05). Increased expression of ADR2 mRNA significantly related to MMP-9 (r = 0.210), and CRP (r = 0.531) (P < 0.05).
Conclusion
Increased mRNA and protein expression of adiponectin receptors is related with increased aortic stiffness, coronary and peripheral atherosclerosis in patients with CAD. The interrelation of AdipoR2 with inflammatory markers, PWV and IMT suggests a compensatory increase of these receptors to counteract the excess inflammatory and atherogenic process in CAD. Thus, adiponectin receptors may provide a potential therapeutic target of agents activating their beneficial action.</description><subject>Adiponectin - blood</subject><subject>Aged</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiology. Vascular system</subject><subject>Carotid Intima-Media Thickness</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Coronary Artery Disease - physiopathology</subject><subject>Cross-Sectional Studies</subject><subject>Diagnostic Techniques, Cardiovascular</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Matrix Metalloproteinase 9 - blood</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Monocytes - metabolism</subject><subject>Receptors, Adiponectin - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Vascular Stiffness</subject><subject>Waist-Hip Ratio</subject><issn>0895-7061</issn><issn>1941-7225</issn><issn>1879-1905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp90V2LEzEUBuAgiltXr7yXgCiCTM13Zy6Humph1WVVvBwymRM2ZZrMJhmwP8T_a7qtCl4IgRDOw8k5vAg9pWRJCa_f6O3NkhHKloLdQwvaCFqtGJP30YLUjaxWRNEz9CilLSFEKEUforNS5mLV8AX62cYM0ekRf8nOWg8p4U3CbUrBOJ1hwN9dvsEbbyLoVJ4fgw9mnwFf_Jhi0S54HCxuBzcFDyY7j6_BwJRDxLvrTy3WfsBXMWQolXKudHbgczr2XYcYvI57fDfGHr916fDNY_TA6jHBk9N9jr69u_i6_lBdfn6_WbeXlRFU5kpa4DUQTimphRFNb-0AoKDuNVWil3XPZMN7qgZQgzBkAENsw4xkptHc9vwcvTr2nWK4nSHlbueSgXHUHsKcOkoYZXLFSVPo83_oNszRl-kOitRKSaWKen1UJoaUIthuim5XFiyoO6TVlbS6Q1qdYEU_O_Wc-x0Mf-zveAp4cQI6GT3aqL1x6a9TZW92N9zLowvz9N8ffwE0WqrB</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>Ikonomidis, Ignatios</creator><creator>Kadoglou, Nikolaos</creator><creator>Tsiotra, Panayoula C.</creator><creator>Kollias, Anastasios</creator><creator>Palios, Ioannis</creator><creator>Fountoulaki, Katerina</creator><creator>Halvatsiotis, Iosif</creator><creator>Maratou, Eirini</creator><creator>Dimitriadis, George</creator><creator>Kremastinos, Dimitrios T.</creator><creator>Lekakis, John</creator><creator>Raptis, Sotirios A.</creator><general>Oxford University Press</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20120701</creationdate><title>Arterial Stiffness Is Associated With Increased Monocyte Expression of Adiponectin Receptor mRNA and Protein in Patients With Coronary Artery Disease</title><author>Ikonomidis, Ignatios ; Kadoglou, Nikolaos ; Tsiotra, Panayoula C. ; Kollias, Anastasios ; Palios, Ioannis ; Fountoulaki, Katerina ; Halvatsiotis, Iosif ; Maratou, Eirini ; Dimitriadis, George ; Kremastinos, Dimitrios T. ; Lekakis, John ; Raptis, Sotirios A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-5fe38e0311084c49bffdee6e8ba164b58b2593b16de6d4c0dec0f92c52c9a3fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adiponectin - blood</topic><topic>Aged</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cardiology. Vascular system</topic><topic>Carotid Intima-Media Thickness</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Coronary Artery Disease - physiopathology</topic><topic>Cross-Sectional Studies</topic><topic>Diagnostic Techniques, Cardiovascular</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Matrix Metalloproteinase 9 - blood</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Monocytes - metabolism</topic><topic>Receptors, Adiponectin - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Vascular Stiffness</topic><topic>Waist-Hip Ratio</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ikonomidis, Ignatios</creatorcontrib><creatorcontrib>Kadoglou, Nikolaos</creatorcontrib><creatorcontrib>Tsiotra, Panayoula C.</creatorcontrib><creatorcontrib>Kollias, Anastasios</creatorcontrib><creatorcontrib>Palios, Ioannis</creatorcontrib><creatorcontrib>Fountoulaki, Katerina</creatorcontrib><creatorcontrib>Halvatsiotis, Iosif</creatorcontrib><creatorcontrib>Maratou, Eirini</creatorcontrib><creatorcontrib>Dimitriadis, George</creatorcontrib><creatorcontrib>Kremastinos, Dimitrios T.</creatorcontrib><creatorcontrib>Lekakis, John</creatorcontrib><creatorcontrib>Raptis, Sotirios A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ikonomidis, Ignatios</au><au>Kadoglou, Nikolaos</au><au>Tsiotra, Panayoula C.</au><au>Kollias, Anastasios</au><au>Palios, Ioannis</au><au>Fountoulaki, Katerina</au><au>Halvatsiotis, Iosif</au><au>Maratou, Eirini</au><au>Dimitriadis, George</au><au>Kremastinos, Dimitrios T.</au><au>Lekakis, John</au><au>Raptis, Sotirios A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Arterial Stiffness Is Associated With Increased Monocyte Expression of Adiponectin Receptor mRNA and Protein in Patients With Coronary Artery Disease</atitle><jtitle>American journal of hypertension</jtitle><addtitle>Am J Hypertens</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>25</volume><issue>7</issue><spage>746</spage><epage>755</epage><pages>746-755</pages><issn>0895-7061</issn><eissn>1941-7225</eissn><eissn>1879-1905</eissn><coden>AJHYE6</coden><abstract>Background
Arterial stiffness and carotid intima-media thickness (IMT) constitute validated cardiovascular prognostic markers. Adiponectin and its receptors 1 (AdipoR1) and 2 (AdipoR2) are involved in coronary artery disease (CAD). We investigated whether AdipoR1 and R2 mRNA and protein expression are associated with arterial stiffness, IMT and extent of coronary atherosclerosis.
Methods
We studied 71 patients (61 men, 10 women) with angiographically proven CAD. We measured: (i) monocyte expression of AdipoR1 and AdipoR2 mRNA (quantitative real-time PCR) and protein expression (flow cytometry) (iii) adiponectin, metalloproteinase-9 (MMP-9) and C-reactive protein (CRP) blood levels, (iv) carotid-femoral artery pulse wave velocity (PWV) and carotid IMT.
Results
Patients with multi-vessel CAD had higher AdipoR1 and AdipoR2 mRNA than those with single-vessel (P < 0.05). PWV was associated with AdipoR1 mRNA (r = 0.474), AdipoR1 protein (r = 0.228), AdipoR2 mRNA (r = 0.716), AdipoR2-protein (r = 0.261), adiponectin (r = 0.236), and MMP-9 (r = 0.350) (P < 0.05, for all correlations). After adjustment for age, sex, waist-hip ratio, and mean blood pressure both AdipoR1 and AdipoR2 mRNA remained independent determinants of PWV (R
2 = 0.35 and R
2 = 0.57, P < 0.05). IMT was also associated with AdipoR2 mRNA, AdipoR2 protein, and MMP-9 (P < 0.05). Increased expression of ADR2 mRNA significantly related to MMP-9 (r = 0.210), and CRP (r = 0.531) (P < 0.05).
Conclusion
Increased mRNA and protein expression of adiponectin receptors is related with increased aortic stiffness, coronary and peripheral atherosclerosis in patients with CAD. The interrelation of AdipoR2 with inflammatory markers, PWV and IMT suggests a compensatory increase of these receptors to counteract the excess inflammatory and atherogenic process in CAD. Thus, adiponectin receptors may provide a potential therapeutic target of agents activating their beneficial action.</abstract><cop>Basingstoke</cop><pub>Oxford University Press</pub><pmid>22534793</pmid><doi>10.1038/ajh.2012.42</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0895-7061 |
| ispartof | American journal of hypertension, 2012-07, Vol.25 (7), p.746-755 |
| issn | 0895-7061 1941-7225 1879-1905 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adiponectin - blood Aged Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels C-Reactive Protein - metabolism Cardiology. Vascular system Carotid Intima-Media Thickness Clinical manifestations. Epidemiology. Investigative techniques. Etiology Coronary Artery Disease - physiopathology Cross-Sectional Studies Diagnostic Techniques, Cardiovascular Female Humans Male Matrix Metalloproteinase 9 - blood Medical sciences Middle Aged Monocytes - metabolism Receptors, Adiponectin - genetics RNA, Messenger - metabolism Vascular Stiffness Waist-Hip Ratio |
| title | Arterial Stiffness Is Associated With Increased Monocyte Expression of Adiponectin Receptor mRNA and Protein in Patients With Coronary Artery Disease |
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