Low plasma carnosinase activity promotes carnosinemia after carnosine ingestion in humans

A polymorphism in the carnosine dipeptidase-1 gene (CNDP1), resulting in decreased plasma carnosinase activity, is associated with a reduced risk for diabetic nephropathy. Because carnosine, a natural scavenger/suppressor of ROS, advanced glycation end products, and reactive aldehydes, is readily de...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2012-06, Vol.302 (12), p.F1537-F1544
Hauptverfasser:	Everaert, Inge, Taes, Youri, De Heer, Emile, Baelde, Hans, Zutinic, Ana, Yard, Benito, Sauerhöfer, Sibylle, Vanhee, Lander, Delanghe, Joris, Aldini, Giancarlo, Derave, Wim
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult beta-Alanine - blood Blood Carnosine - administration & dosage Chromatography, High Pressure Liquid Diabetic Nephropathies - genetics Dipeptidases - blood Dipeptidases - genetics Dipeptidases - urine Female Genotype & phenotype Humans Male Metabolic disorders Peptides Physiology Plasma
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