Reduced nuclear and ectopic cytoplasmic expression of lysyl oxidase–like 2 is associated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma
Summary Lysyl oxidase family members have various roles in cancer progression. The aim of this study was to investigate their expression and clinical significance in esophageal squamous cell carcinoma. We examined messenger RNA expression of lysyl oxidase family members including lysyl oxidase and l...
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| Veröffentlicht in: | Human pathology 2012-07, Vol.43 (7), p.1068-1076 |
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| creator | Li, Tian-Yu, PhD Xu, Li-Yan, PhD Wu, Zhi-Yong, MD Liao, Lian-Di, BS Shen, Jin-Hui, MD Xu, Xiu-E, BS Du, Ze-Peng, PhD Zhao, Qing, MS Li, En-Min, PhD |
| description | Summary Lysyl oxidase family members have various roles in cancer progression. The aim of this study was to investigate their expression and clinical significance in esophageal squamous cell carcinoma. We examined messenger RNA expression of lysyl oxidase family members including lysyl oxidase and lysyl oxidase–like proteins (lysyl oxidase L) in 10 esophageal squamous cell carcinoma cell lines and 83 pairs of tumor samples by quantitative real-time polymerase chain reaction. All except lysyl oxidase L3 were expressed at high levels in esophageal squamous cell carcinoma, but only lysyl oxidase L2 was associated with lymph node metastasis ( P = .034). We examined lysyl oxidase L2 protein further by immunohistochemistry staining in 178 surgically resected esophageal squamous cell carcinoma tissue samples. The protein manifested decreased nuclear expression and increased cytoplasmic expression. Moreover, these 2 events both had significant correlation with the presence of lymph node metastasis ( P = .001 and P < .001). Overall survival rates of the patients with esophageal squamous cell carcinoma with decreased nuclear expression or increased cytoplasmic expression of lysyl oxidase L2 were significantly lower than those of the patients with esophageal squamous cell carcinoma with the reverse expression pattern ( P = .040 or P = .022). Multivariate analyses revealed that nuclear expression of lysyl oxidase L2 was an independent prognostic factor for esophageal squamous cell carcinoma. These results suggest that lysyl oxidase L2 exerts a critical effect on esophageal squamous cell carcinoma progression and can be a predictive marker of lymph node metastasis and outcome. |
| doi_str_mv | 10.1016/j.humpath.2011.07.027 |
| format | Article |
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The aim of this study was to investigate their expression and clinical significance in esophageal squamous cell carcinoma. We examined messenger RNA expression of lysyl oxidase family members including lysyl oxidase and lysyl oxidase–like proteins (lysyl oxidase L) in 10 esophageal squamous cell carcinoma cell lines and 83 pairs of tumor samples by quantitative real-time polymerase chain reaction. All except lysyl oxidase L3 were expressed at high levels in esophageal squamous cell carcinoma, but only lysyl oxidase L2 was associated with lymph node metastasis ( P = .034). We examined lysyl oxidase L2 protein further by immunohistochemistry staining in 178 surgically resected esophageal squamous cell carcinoma tissue samples. The protein manifested decreased nuclear expression and increased cytoplasmic expression. Moreover, these 2 events both had significant correlation with the presence of lymph node metastasis ( P = .001 and P < .001). Overall survival rates of the patients with esophageal squamous cell carcinoma with decreased nuclear expression or increased cytoplasmic expression of lysyl oxidase L2 were significantly lower than those of the patients with esophageal squamous cell carcinoma with the reverse expression pattern ( P = .040 or P = .022). Multivariate analyses revealed that nuclear expression of lysyl oxidase L2 was an independent prognostic factor for esophageal squamous cell carcinoma. These results suggest that lysyl oxidase L2 exerts a critical effect on esophageal squamous cell carcinoma progression and can be a predictive marker of lymph node metastasis and outcome.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/j.humpath.2011.07.027</identifier><identifier>PMID: 22204712</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Amino Acid Oxidoreductases - genetics ; Amino Acid Oxidoreductases - metabolism ; Biological and medical sciences ; Breast cancer ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Cell Line, Tumor ; Cell Nucleus - metabolism ; Cell Nucleus - pathology ; Cytoplasm - metabolism ; Cytoplasm - pathology ; Esophageal Neoplasms - genetics ; Esophageal Neoplasms - metabolism ; Esophageal Neoplasms - mortality ; Esophageal Neoplasms - pathology ; Esophageal squamous cell carcinoma ; Esophagus ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Hematologic and hematopoietic diseases ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphatic Metastasis - pathology ; Lysyl oxidase–like 2 ; Male ; Medical research ; Medical sciences ; Middle Aged ; Pathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Prognosis ; Prognostic factors ; Proteins ; Studies ; Survival Rate ; Tumor Cells, Cultured ; Tumors</subject><ispartof>Human pathology, 2012-07, Vol.43 (7), p.1068-1076</ispartof><rights>Elsevier Inc.</rights><rights>2012 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-fedd7180059bca4188e837ffb244a1e88309f82bc4e9b5818aac5f0539f7e9f83</citedby><cites>FETCH-LOGICAL-c478t-fedd7180059bca4188e837ffb244a1e88309f82bc4e9b5818aac5f0539f7e9f83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.humpath.2011.07.027$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26016867$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22204712$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Tian-Yu, PhD</creatorcontrib><creatorcontrib>Xu, Li-Yan, PhD</creatorcontrib><creatorcontrib>Wu, Zhi-Yong, MD</creatorcontrib><creatorcontrib>Liao, Lian-Di, BS</creatorcontrib><creatorcontrib>Shen, Jin-Hui, MD</creatorcontrib><creatorcontrib>Xu, Xiu-E, BS</creatorcontrib><creatorcontrib>Du, Ze-Peng, PhD</creatorcontrib><creatorcontrib>Zhao, Qing, MS</creatorcontrib><creatorcontrib>Li, En-Min, PhD</creatorcontrib><title>Reduced nuclear and ectopic cytoplasmic expression of lysyl oxidase–like 2 is associated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Summary Lysyl oxidase family members have various roles in cancer progression. The aim of this study was to investigate their expression and clinical significance in esophageal squamous cell carcinoma. We examined messenger RNA expression of lysyl oxidase family members including lysyl oxidase and lysyl oxidase–like proteins (lysyl oxidase L) in 10 esophageal squamous cell carcinoma cell lines and 83 pairs of tumor samples by quantitative real-time polymerase chain reaction. All except lysyl oxidase L3 were expressed at high levels in esophageal squamous cell carcinoma, but only lysyl oxidase L2 was associated with lymph node metastasis ( P = .034). We examined lysyl oxidase L2 protein further by immunohistochemistry staining in 178 surgically resected esophageal squamous cell carcinoma tissue samples. The protein manifested decreased nuclear expression and increased cytoplasmic expression. Moreover, these 2 events both had significant correlation with the presence of lymph node metastasis ( P = .001 and P < .001). Overall survival rates of the patients with esophageal squamous cell carcinoma with decreased nuclear expression or increased cytoplasmic expression of lysyl oxidase L2 were significantly lower than those of the patients with esophageal squamous cell carcinoma with the reverse expression pattern ( P = .040 or P = .022). Multivariate analyses revealed that nuclear expression of lysyl oxidase L2 was an independent prognostic factor for esophageal squamous cell carcinoma. These results suggest that lysyl oxidase L2 exerts a critical effect on esophageal squamous cell carcinoma progression and can be a predictive marker of lymph node metastasis and outcome.</description><subject>Aged</subject><subject>Amino Acid Oxidoreductases - genetics</subject><subject>Amino Acid Oxidoreductases - metabolism</subject><subject>Biological and medical sciences</subject><subject>Breast cancer</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cell Line, Tumor</subject><subject>Cell Nucleus - metabolism</subject><subject>Cell Nucleus - pathology</subject><subject>Cytoplasm - metabolism</subject><subject>Cytoplasm - pathology</subject><subject>Esophageal Neoplasms - genetics</subject><subject>Esophageal Neoplasms - metabolism</subject><subject>Esophageal Neoplasms - mortality</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophageal squamous cell carcinoma</subject><subject>Esophagus</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Lysyl oxidase–like 2</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Prognosis</subject><subject>Prognostic factors</subject><subject>Proteins</subject><subject>Studies</subject><subject>Survival Rate</subject><subject>Tumor Cells, Cultured</subject><subject>Tumors</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkt-K1DAUxoMo7jr6CEpABG9mTNJ2kt4osvgPFgT_XIcz6elOZtukm9Pqzp3v4Hv4UD6JKTO6sDdC4ITkl-98yRfGHkuxkkKuX-xW26kfYNyulJByJfRKKH2HncqqUEtT1OouOxWiXC-N1PqEPSDaiQxWZXWfnSilRKmlOmW_PmEzOWx4mFyHkDiEhqMb4-Add_tcO6A-z_F6SEjkY-Cx5d2e9h2P174Bwt8_fnb-ErninjgQRedhzJLf_bjNZD9seYgN8h5HoDxmKncZYkx8SPEixHnJB44Uhy1cIHScribo40TcYddxB8n5EHt4yO610BE-OtYF-_r2zZez98vzj-8-nL0-X7pSm3HZYtNoaYSo6o2DUhqDptBtu1FlCRKNKUTdGrVxJdabykgD4KpWVEXdasw7xYI9P-hmf1cT0mh7T7MVCJhdWSmUlKqqS5nRp7fQXZxSyO4yVazrqtC5Llh1oFyKRAlbOyTfQ9pnyM6B2p09BmrnQK3QNgeazz05qk-bHpt_p_4mmIFnRwDIQdcmCM7TDbfO2mY9C706cJif7ZvHZMl5DDl6n3Leton-v1Ze3lJwnQ8-N73EPdLNrS0pK-zn-ffNn09KIQotyuIP_Kna9A</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>Li, Tian-Yu, PhD</creator><creator>Xu, Li-Yan, PhD</creator><creator>Wu, Zhi-Yong, MD</creator><creator>Liao, Lian-Di, BS</creator><creator>Shen, Jin-Hui, MD</creator><creator>Xu, Xiu-E, BS</creator><creator>Du, Ze-Peng, PhD</creator><creator>Zhao, Qing, MS</creator><creator>Li, En-Min, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20120701</creationdate><title>Reduced nuclear and ectopic cytoplasmic expression of lysyl oxidase–like 2 is associated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma</title><author>Li, Tian-Yu, PhD ; Xu, Li-Yan, PhD ; Wu, Zhi-Yong, MD ; Liao, Lian-Di, BS ; Shen, Jin-Hui, MD ; Xu, Xiu-E, BS ; Du, Ze-Peng, PhD ; Zhao, Qing, MS ; Li, En-Min, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-fedd7180059bca4188e837ffb244a1e88309f82bc4e9b5818aac5f0539f7e9f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Amino Acid Oxidoreductases - genetics</topic><topic>Amino Acid Oxidoreductases - metabolism</topic><topic>Biological and medical sciences</topic><topic>Breast cancer</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cell Line, Tumor</topic><topic>Cell Nucleus - metabolism</topic><topic>Cell Nucleus - pathology</topic><topic>Cytoplasm - metabolism</topic><topic>Cytoplasm - pathology</topic><topic>Esophageal Neoplasms - genetics</topic><topic>Esophageal Neoplasms - metabolism</topic><topic>Esophageal Neoplasms - mortality</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophageal squamous cell carcinoma</topic><topic>Esophagus</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Lysyl oxidase–like 2</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pathology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Prognosis</topic><topic>Prognostic factors</topic><topic>Proteins</topic><topic>Studies</topic><topic>Survival Rate</topic><topic>Tumor Cells, Cultured</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Tian-Yu, PhD</creatorcontrib><creatorcontrib>Xu, Li-Yan, PhD</creatorcontrib><creatorcontrib>Wu, Zhi-Yong, MD</creatorcontrib><creatorcontrib>Liao, Lian-Di, BS</creatorcontrib><creatorcontrib>Shen, Jin-Hui, MD</creatorcontrib><creatorcontrib>Xu, Xiu-E, BS</creatorcontrib><creatorcontrib>Du, Ze-Peng, PhD</creatorcontrib><creatorcontrib>Zhao, Qing, MS</creatorcontrib><creatorcontrib>Li, En-Min, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Tian-Yu, PhD</au><au>Xu, Li-Yan, PhD</au><au>Wu, Zhi-Yong, MD</au><au>Liao, Lian-Di, BS</au><au>Shen, Jin-Hui, MD</au><au>Xu, Xiu-E, BS</au><au>Du, Ze-Peng, PhD</au><au>Zhao, Qing, MS</au><au>Li, En-Min, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced nuclear and ectopic cytoplasmic expression of lysyl oxidase–like 2 is associated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>43</volume><issue>7</issue><spage>1068</spage><epage>1076</epage><pages>1068-1076</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>Summary Lysyl oxidase family members have various roles in cancer progression. The aim of this study was to investigate their expression and clinical significance in esophageal squamous cell carcinoma. We examined messenger RNA expression of lysyl oxidase family members including lysyl oxidase and lysyl oxidase–like proteins (lysyl oxidase L) in 10 esophageal squamous cell carcinoma cell lines and 83 pairs of tumor samples by quantitative real-time polymerase chain reaction. All except lysyl oxidase L3 were expressed at high levels in esophageal squamous cell carcinoma, but only lysyl oxidase L2 was associated with lymph node metastasis ( P = .034). We examined lysyl oxidase L2 protein further by immunohistochemistry staining in 178 surgically resected esophageal squamous cell carcinoma tissue samples. The protein manifested decreased nuclear expression and increased cytoplasmic expression. Moreover, these 2 events both had significant correlation with the presence of lymph node metastasis ( P = .001 and P < .001). Overall survival rates of the patients with esophageal squamous cell carcinoma with decreased nuclear expression or increased cytoplasmic expression of lysyl oxidase L2 were significantly lower than those of the patients with esophageal squamous cell carcinoma with the reverse expression pattern ( P = .040 or P = .022). Multivariate analyses revealed that nuclear expression of lysyl oxidase L2 was an independent prognostic factor for esophageal squamous cell carcinoma. These results suggest that lysyl oxidase L2 exerts a critical effect on esophageal squamous cell carcinoma progression and can be a predictive marker of lymph node metastasis and outcome.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>22204712</pmid><doi>10.1016/j.humpath.2011.07.027</doi><tpages>9</tpages></addata></record> |
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| subjects | Aged Amino Acid Oxidoreductases - genetics Amino Acid Oxidoreductases - metabolism Biological and medical sciences Breast cancer Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Cell Line, Tumor Cell Nucleus - metabolism Cell Nucleus - pathology Cytoplasm - metabolism Cytoplasm - pathology Esophageal Neoplasms - genetics Esophageal Neoplasms - metabolism Esophageal Neoplasms - mortality Esophageal Neoplasms - pathology Esophageal squamous cell carcinoma Esophagus Female Gastroenterology. Liver. Pancreas. Abdomen Hematologic and hematopoietic diseases Humans Investigative techniques, diagnostic techniques (general aspects) Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphatic Metastasis - pathology Lysyl oxidase–like 2 Male Medical research Medical sciences Middle Aged Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Prognosis Prognostic factors Proteins Studies Survival Rate Tumor Cells, Cultured Tumors |
| title | Reduced nuclear and ectopic cytoplasmic expression of lysyl oxidase–like 2 is associated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma |
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