The Novel Reversible Fatty Acid Amide Hydrolase Inhibitor ST4070 Increases Endocannabinoid Brain Levels and Counteracts Neuropathic Pain in Different Animal Models

The effect of the enol carbamate 1-biphenyl-4-ylethenyl piperidine-1-carboxylate (ST4070), a novel reversible inhibitor of fatty acid amide hydrolase (FAAH), was investigated for acute pain sensitivity and neuropathic pain in rats and mice. Brain enzymatic activity of FAAH and the endogenous levels...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2012-07, Vol.342 (1), p.188-195
Hauptverfasser:	Caprioli, Antonio, Coccurello, Roberto, Rapino, Cinzia, Di Serio, Stefano, Di Tommaso, Monia, Vertechy, Mario, Vacca, Valentina, Battista, Natalia, Pavone, Flaminia, Maccarrone, Mauro, Borsini, Franco
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Pain - drug therapy Acute Pain - metabolism Amidohydrolases - antagonists & inhibitors Amidohydrolases - metabolism Analgesics - pharmacology Animals Arachidonic Acids - metabolism Brain - drug effects Brain - metabolism Endocannabinoids - metabolism Glycerides - metabolism Male Mice Mice, Inbred NOD Neuralgia - drug therapy Neuralgia - metabolism Polyunsaturated Alkamides - metabolism Rats Rats, Sprague-Dawley
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