Altered microRNA expression in B lymphocytes in multiple sclerosis: Towards a better understanding of treatment effects

MicroRNAs (miRNAs) are posttranscriptional regulators of gene expression. We compared the expression of 1059 miRNAs in B lymphocytes from untreated and natalizumab treated relapsing-remitting multiple sclerosis (RRMS) patients and healthy volunteers (HV). Forty nine miRNAs were down-regulated in unt...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2012-07, Vol.144 (1), p.70-79
Hauptverfasser:	SIEVERS, Claudia, MEIRA, Maria, HOFFMANN, Francine, FONTOURA, Paulo, KAPPOS, Ludwig, LINDBERG, Raija L. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal, Humanized - therapeutic use B-Lymphocytes - immunology Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Male Medical sciences MicroRNAs - immunology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Multiple Sclerosis, Relapsing-Remitting - drug therapy Multiple Sclerosis, Relapsing-Remitting - genetics Multiple Sclerosis, Relapsing-Remitting - immunology Natalizumab Neurology
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