Heme oxygenase microsatellite polymorphism, oxidative stress, glycemic control, and complication development in type 2 diabetes patients

Heme oxygenase-1 (HMOX-1) is activated by oxidative stress, and gene responsiveness is reportedly determined by the number of dinucleotide (GT(n)) repeats in its highly polymorphic promoter region. “Short” (S; GT(n)

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Bibliographische Detailangaben
Veröffentlicht in:	Free radical biology & medicine 2012-07, Vol.53 (1), p.60-63
Hauptverfasser:	Choi, Siu-Wai, Fai Yeung, Vincent Tok, Benzie, Iris F.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	alleles antioxidants biomarkers blood Blood Glucose death Diabetes Complications - etiology Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - physiopathology Diabetic complications DNA damage fasting Female Free radicals Genetic Predisposition to Disease Genotype genotyping glucose glycemic control glycohemoglobin GT repeats heme oxygenase (biliverdin-producing) Heme oxygenase-1 Heme Oxygenase-1 - genetics Humans lipids Male microsatellite repeats Microsatellite Repeats - genetics Middle Aged noninsulin-dependent diabetes mellitus Oxidative Stress patients Polymorphism, Genetic - genetics promoter regions Promoter Regions, Genetic - genetics risk Risk Factors Type 2 diabetes
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Beschreibung
Zusammenfassung:	Heme oxygenase-1 (HMOX-1) is activated by oxidative stress, and gene responsiveness is reportedly determined by the number of dinucleotide (GT(n)) repeats in its highly polymorphic promoter region. “Short” (S; GT(n)
ISSN:	0891-5849 1873-4596
DOI:	10.1016/j.freeradbiomed.2012.04.017