Neutrophil gelatinase-associated lipocalin (NGAL) in inflammatory bowel disease: association with pathophysiology of inflammation, established markers, and disease activity

Background Neutrophil gelatinase-associated lipocalin (NGAL) is a multi-potent 25-kDa protein mainly secreted by neutrophils. In inflammatory bowel disease (IBD), overexpression of NGAL in colon epithelium has been previously shown. This is the first study analyzing serum and urinary NGAL levels in...

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Veröffentlicht in:	Journal of gastroenterology 2012-05, Vol.47 (5), p.519-530
Hauptverfasser:	Oikonomou, K. A., Kapsoritakis, A. N., Theodoridou, C., Karangelis, D., Germenis, A., Stefanidis, I., Potamianos, S. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal Surgery Acute-Phase Proteins - physiology Acute-Phase Proteins - urine Adolescent Adult Aged Biomarkers - blood Biomarkers - urine Blood C-reactive protein C-Reactive Protein - metabolism Case-Control Studies Colitis, Ulcerative - diagnosis Colitis, Ulcerative - metabolism Colitis, Ulcerative - physiopathology Colon Colorectal Surgery Comparative analysis Crohn Disease - diagnosis Crohn Disease - metabolism Crohn Disease - physiopathology Crohn's disease Diagnosis, Differential Epithelium Erythrocytes Female Gastroenterology Hepatology Humans Inflammation Inflammatory bowel disease Inflammatory bowel diseases Inflammatory Bowel Diseases - diagnosis Inflammatory Bowel Diseases - metabolism Inflammatory Bowel Diseases - physiopathology Irritable bowel syndrome Irritable Bowel Syndrome - diagnosis Irritable Bowel Syndrome - metabolism Irritable Bowel Syndrome - physiopathology Leukocytes (neutrophilic) Lipocalin Lipocalin-2 Lipocalins - blood Lipocalins - physiology Lipocalins - urine Male Medical examination Medicine Medicine & Public Health Middle Aged Original Article—Alimentary Tract Proto-Oncogene Proteins - blood Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins - urine Sedimentation Sensitivity and Specificity Severity of Illness Index Surgical Oncology Ulcerative colitis Young Adult
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