Absence of human papillomavirus in patients with breast cancer in north-west China
The purpose of this study was to investigate the human papillomavirus (HPV) infection rate in malignant and benign breast tumours in north-west Chinese patients. Unselected fresh tissue samples were extracted from 48 invasive breast carcinoma and 30 benign breast tumours between August 2009 and Augu...
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| Veröffentlicht in: | Medical oncology (Northwood, London, England) London, England), 2012-06, Vol.29 (2), p.521-525 |
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| container_title | Medical oncology (Northwood, London, England) |
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| creator | Chang, Peng Wang, Ting Yao, Qing Lv, Yonggang Zhang, Juliang Guo, Wen Wang, Ling Chen, Jianghao |
| description | The purpose of this study was to investigate the human papillomavirus (HPV) infection rate in malignant and benign breast tumours in north-west Chinese patients. Unselected fresh tissue samples were extracted from 48 invasive breast carcinoma and 30 benign breast tumours between August 2009 and August 2010. We used real-time fluorescence quantitative PCR (FQ-PCR) and in situ hybridization to detect HPV 6, 11 and 16, 18 sequences targeting the E6, E7 open-reading frame. The presence of HPV 6, 11 was only demonstrated in the 3 (10%) benign phyllodes tumour specimens. No HPV infection was detected in all the 48 invasive breast carcinoma. Specifically, all the positive specimens were detected by in situ hybridization but not in FQ-PCR. In addition, we found that the positive specimens became negative after 3 months frozen at −70°C. HPV was absent in patients with breast tumours in north-west China. |
| doi_str_mv | 10.1007/s12032-011-9945-5 |
| format | Article |
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Unselected fresh tissue samples were extracted from 48 invasive breast carcinoma and 30 benign breast tumours between August 2009 and August 2010. We used real-time fluorescence quantitative PCR (FQ-PCR) and in situ hybridization to detect HPV 6, 11 and 16, 18 sequences targeting the E6, E7 open-reading frame. The presence of HPV 6, 11 was only demonstrated in the 3 (10%) benign phyllodes tumour specimens. No HPV infection was detected in all the 48 invasive breast carcinoma. Specifically, all the positive specimens were detected by in situ hybridization but not in FQ-PCR. In addition, we found that the positive specimens became negative after 3 months frozen at −70°C. HPV was absent in patients with breast tumours in north-west China.</description><identifier>ISSN: 1357-0560</identifier><identifier>EISSN: 1559-131X</identifier><identifier>DOI: 10.1007/s12032-011-9945-5</identifier><identifier>PMID: 21499926</identifier><identifier>CODEN: MONCEZ</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Benign ; Breast cancer ; Breast carcinoma ; Breast Neoplasms - genetics ; Breast Neoplasms - pathology ; Breast Neoplasms - virology ; China ; DNA, Viral - genetics ; Female ; Fluorescence ; Hematology ; Human papillomavirus ; Humans ; In Situ Hybridization ; Infection ; Internal Medicine ; Invasiveness ; Medicine ; Medicine & Public Health ; Neoplasm Invasiveness ; Neoplasm Staging ; Oncogene Proteins, Viral - genetics ; Oncology ; Original Paper ; Papillomaviridae - classification ; Papillomaviridae - genetics ; Papillomavirus E7 Proteins - genetics ; Papillomavirus Infections - genetics ; Papillomavirus Infections - virology ; Pathology ; Polymerase chain reaction ; Prognosis ; Real-Time Polymerase Chain Reaction ; Repressor Proteins - genetics ; Tumors</subject><ispartof>Medical oncology (Northwood, London, England), 2012-06, Vol.29 (2), p.521-525</ispartof><rights>Springer Science+Business Media, LLC 2011</rights><rights>Springer Science+Business Media, LLC 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-eced6270e2b8e5449692bb3dbef799832112bf923d6202935e7eee4f34fa51c53</citedby><cites>FETCH-LOGICAL-c438t-eced6270e2b8e5449692bb3dbef799832112bf923d6202935e7eee4f34fa51c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12032-011-9945-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12032-011-9945-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21499926$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, Peng</creatorcontrib><creatorcontrib>Wang, Ting</creatorcontrib><creatorcontrib>Yao, Qing</creatorcontrib><creatorcontrib>Lv, Yonggang</creatorcontrib><creatorcontrib>Zhang, Juliang</creatorcontrib><creatorcontrib>Guo, Wen</creatorcontrib><creatorcontrib>Wang, Ling</creatorcontrib><creatorcontrib>Chen, Jianghao</creatorcontrib><title>Absence of human papillomavirus in patients with breast cancer in north-west China</title><title>Medical oncology (Northwood, London, England)</title><addtitle>Med Oncol</addtitle><addtitle>Med Oncol</addtitle><description>The purpose of this study was to investigate the human papillomavirus (HPV) infection rate in malignant and benign breast tumours in north-west Chinese patients. Unselected fresh tissue samples were extracted from 48 invasive breast carcinoma and 30 benign breast tumours between August 2009 and August 2010. We used real-time fluorescence quantitative PCR (FQ-PCR) and in situ hybridization to detect HPV 6, 11 and 16, 18 sequences targeting the E6, E7 open-reading frame. The presence of HPV 6, 11 was only demonstrated in the 3 (10%) benign phyllodes tumour specimens. No HPV infection was detected in all the 48 invasive breast carcinoma. Specifically, all the positive specimens were detected by in situ hybridization but not in FQ-PCR. In addition, we found that the positive specimens became negative after 3 months frozen at −70°C. HPV was absent in patients with breast tumours in north-west China.</description><subject>Adult</subject><subject>Benign</subject><subject>Breast cancer</subject><subject>Breast carcinoma</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - virology</subject><subject>China</subject><subject>DNA, Viral - genetics</subject><subject>Female</subject><subject>Fluorescence</subject><subject>Hematology</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>In Situ Hybridization</subject><subject>Infection</subject><subject>Internal Medicine</subject><subject>Invasiveness</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Oncogene Proteins, Viral - genetics</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Papillomaviridae - classification</subject><subject>Papillomaviridae - genetics</subject><subject>Papillomavirus E7 Proteins - genetics</subject><subject>Papillomavirus Infections - genetics</subject><subject>Papillomavirus Infections - virology</subject><subject>Pathology</subject><subject>Polymerase chain reaction</subject><subject>Prognosis</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Repressor Proteins - genetics</subject><subject>Tumors</subject><issn>1357-0560</issn><issn>1559-131X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkVtLxDAQhYMo7rr6A3yRgi--RDO5tM3jsniDBUEUfCtpd2q79LImrYv_3pSuIoLg0wwz35yTcAg5BXYJjEVXDjgTnDIAqrVUVO2RKSilKQh42fe9UBFlKmQTcuTcmjEOiutDMuEgtdY8nJLHeeqwyTBo86Doa9MEG7Mpq6qtzXtpexeUw6QrselcsC27IkgtGtcFmfFXdlg3re0KukU_XBRlY47JQW4qhye7OiPPN9dPizu6fLi9X8yXNJMi7ihmuAp5xJCnMSopdah5mopVinmkdSw4AE9zzYWnGNdCYYSIMhcyNwoyJWbkYtTd2Pat9_ZJXboMq8o02PYuAcZZrJRU8T9QAIhCb-nR81_ouu1t4z8yUELKmMXcUzBSmW2ds5gnG1vWxn54KBmyScZsEi-cDNkkw3vPdsp9WuPq--IrDA_wEXB-1byi_Wn9l-onNXWYIQ</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Chang, Peng</creator><creator>Wang, Ting</creator><creator>Yao, Qing</creator><creator>Lv, Yonggang</creator><creator>Zhang, Juliang</creator><creator>Guo, Wen</creator><creator>Wang, Ling</creator><creator>Chen, Jianghao</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20120601</creationdate><title>Absence of human papillomavirus in patients with breast cancer in north-west China</title><author>Chang, Peng ; Wang, Ting ; Yao, Qing ; Lv, Yonggang ; Zhang, Juliang ; Guo, Wen ; Wang, Ling ; Chen, Jianghao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-eced6270e2b8e5449692bb3dbef799832112bf923d6202935e7eee4f34fa51c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Benign</topic><topic>Breast cancer</topic><topic>Breast carcinoma</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - virology</topic><topic>China</topic><topic>DNA, Viral - genetics</topic><topic>Female</topic><topic>Fluorescence</topic><topic>Hematology</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>In Situ Hybridization</topic><topic>Infection</topic><topic>Internal Medicine</topic><topic>Invasiveness</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Oncogene Proteins, Viral - genetics</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>Papillomaviridae - classification</topic><topic>Papillomaviridae - genetics</topic><topic>Papillomavirus E7 Proteins - genetics</topic><topic>Papillomavirus Infections - genetics</topic><topic>Papillomavirus Infections - virology</topic><topic>Pathology</topic><topic>Polymerase chain reaction</topic><topic>Prognosis</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Repressor Proteins - genetics</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, Peng</creatorcontrib><creatorcontrib>Wang, Ting</creatorcontrib><creatorcontrib>Yao, Qing</creatorcontrib><creatorcontrib>Lv, Yonggang</creatorcontrib><creatorcontrib>Zhang, Juliang</creatorcontrib><creatorcontrib>Guo, Wen</creatorcontrib><creatorcontrib>Wang, Ling</creatorcontrib><creatorcontrib>Chen, Jianghao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Medical oncology (Northwood, London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, Peng</au><au>Wang, Ting</au><au>Yao, Qing</au><au>Lv, Yonggang</au><au>Zhang, Juliang</au><au>Guo, Wen</au><au>Wang, Ling</au><au>Chen, Jianghao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Absence of human papillomavirus in patients with breast cancer in north-west China</atitle><jtitle>Medical oncology (Northwood, London, England)</jtitle><stitle>Med Oncol</stitle><addtitle>Med Oncol</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>29</volume><issue>2</issue><spage>521</spage><epage>525</epage><pages>521-525</pages><issn>1357-0560</issn><eissn>1559-131X</eissn><coden>MONCEZ</coden><abstract>The purpose of this study was to investigate the human papillomavirus (HPV) infection rate in malignant and benign breast tumours in north-west Chinese patients. Unselected fresh tissue samples were extracted from 48 invasive breast carcinoma and 30 benign breast tumours between August 2009 and August 2010. We used real-time fluorescence quantitative PCR (FQ-PCR) and in situ hybridization to detect HPV 6, 11 and 16, 18 sequences targeting the E6, E7 open-reading frame. The presence of HPV 6, 11 was only demonstrated in the 3 (10%) benign phyllodes tumour specimens. No HPV infection was detected in all the 48 invasive breast carcinoma. Specifically, all the positive specimens were detected by in situ hybridization but not in FQ-PCR. In addition, we found that the positive specimens became negative after 3 months frozen at −70°C. HPV was absent in patients with breast tumours in north-west China.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>21499926</pmid><doi>10.1007/s12032-011-9945-5</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Benign Breast cancer Breast carcinoma Breast Neoplasms - genetics Breast Neoplasms - pathology Breast Neoplasms - virology China DNA, Viral - genetics Female Fluorescence Hematology Human papillomavirus Humans In Situ Hybridization Infection Internal Medicine Invasiveness Medicine Medicine & Public Health Neoplasm Invasiveness Neoplasm Staging Oncogene Proteins, Viral - genetics Oncology Original Paper Papillomaviridae - classification Papillomaviridae - genetics Papillomavirus E7 Proteins - genetics Papillomavirus Infections - genetics Papillomavirus Infections - virology Pathology Polymerase chain reaction Prognosis Real-Time Polymerase Chain Reaction Repressor Proteins - genetics Tumors |
| title | Absence of human papillomavirus in patients with breast cancer in north-west China |
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