Anti-inflammatory activity of Korean thistle Cirsium maackii and its major flavonoid, luteolin 5-O-glucoside

► Luteolin 5-O-glucoside from C. mackii whole plants possess anti-inflammatory activity. ► The presence of a 5-O-glucosyl group in luteolin is required to reduce the cytotoxicity. ► Luteolin 5-O-glucoside inhibited LPS-induced NO production. ► It also inhibited t-BHP-induced ROS generation. ► It sup...

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Veröffentlicht in:	Food and chemical toxicology 2012-06, Vol.50 (6), p.2171-2179
Hauptverfasser:	Jung, Hyun Ah, Jin, Seong Eun, Min, Byung-Sun, Kim, Byung-Woo, Choi, Jae Sue
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Anti-inflammatory anti-inflammatory activity Anti-Inflammatory Agents, Non-Steroidal Cell Survival - drug effects Chromatography, High Pressure Liquid Cirsium Cirsium - chemistry Cirsium maackii Cyclooxygenase 2 Inhibitors - pharmacology dose response Dose-Response Relationship, Drug Escherichia coli - chemistry Flavones - chemistry Flavones - pharmacology Glucosides - chemistry Glucosides - pharmacology high performance liquid chromatography HPLC inducible nitric oxide synthase Inflammation - chemically induced Inflammation - prevention & control lipopolysaccharides Lipopolysaccharides - pharmacology luteolin Luteolin 5-O-glucoside macrophages Macrophages - drug effects Mice Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type II - antagonists & inhibitors Plant Extracts - pharmacology prostaglandin synthase protein synthesis Reactive Oxygen Species Solvents Spectrophotometry, Ultraviolet tert-Butylhydroperoxide toxicology
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