Post-Acquisition Release of Glutamate and Norepinephrine in the Amygdala Is Involved in Taste-Aversion Memory Consolidation
Amygdala activity mediates the acquisition and consolidation of emotional experiences; we have recently shown that post-acquisition reactivation of this structure is necessary for the long-term storage of conditioned taste aversion (CTA). However, the specific neurotransmitters involved in such reac...
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| Veröffentlicht in: | Learning & memory (Cold Spring Harbor, N.Y.) N.Y.), 2012-05, Vol.19 (6), p.231-238 |
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| creator | Guzman-Ramos, Kioko Osorio-Gomez, Daniel Moreno-Castilla, Perla Bermudez-Rattoni, Federico |
| description | Amygdala activity mediates the acquisition and consolidation of emotional experiences; we have recently shown that post-acquisition reactivation of this structure is necessary for the long-term storage of conditioned taste aversion (CTA). However, the specific neurotransmitters involved in such reactivation are not known. The aim of the present study was to investigate extracellular changes of glutamate, norepinephrine, and dopamine within the rat amygdala using in vivo microdialysis during the acquisition and 1-h post-acquisition of CTA paradigm. Microdialysis monitoring showed a significant norepinephrine increase related to novel taste exposure and a glutamate increase after gastric malaise induction by i.p. LiCl administration. Interestingly, we found a spontaneous concomitant increase of glutamate and norepinephrine, but not dopamine, 45 min after conditioning, suggesting the presence of aversive learning-dependent post-acquisition signals in the amygdala. These signals seem to be involved in CTA consolidation process, since post-trial blockade of N-methyl-D-aspartate or [beta]-adrenergic receptors impaired long- but not short-term memory. These data suggest that CTA long-term storage involves post-acquisition release of glutamate and norepinephrine in the amygdala. |
| doi_str_mv | 10.1101/lm.024703.111 |
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However, the specific neurotransmitters involved in such reactivation are not known. The aim of the present study was to investigate extracellular changes of glutamate, norepinephrine, and dopamine within the rat amygdala using in vivo microdialysis during the acquisition and 1-h post-acquisition of CTA paradigm. Microdialysis monitoring showed a significant norepinephrine increase related to novel taste exposure and a glutamate increase after gastric malaise induction by i.p. LiCl administration. Interestingly, we found a spontaneous concomitant increase of glutamate and norepinephrine, but not dopamine, 45 min after conditioning, suggesting the presence of aversive learning-dependent post-acquisition signals in the amygdala. These signals seem to be involved in CTA consolidation process, since post-trial blockade of N-methyl-D-aspartate or [beta]-adrenergic receptors impaired long- but not short-term memory. 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These data suggest that CTA long-term storage involves post-acquisition release of glutamate and norepinephrine in the amygdala.</description><subject>Adrenergic beta-Antagonists - pharmacology</subject><subject>Amygdala</subject><subject>Amygdala - drug effects</subject><subject>Amygdala - metabolism</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Area Under Curve</subject><subject>Avoidance Learning - physiology</subject><subject>Biochemistry</subject><subject>Conditioning, Classical - physiology</subject><subject>Data processing</subject><subject>Dopamine</subject><subject>Dopamine - metabolism</subject><subject>Emotional Experience</subject><subject>Emotions</subject><subject>Excitatory Amino Acid Antagonists - pharmacology</subject><subject>Experimental Psychology</subject><subject>Experiments</subject><subject>Glutamic acid</subject><subject>Glutamic Acid - metabolism</subject><subject>Glutamic acid receptors</subject><subject>Learning Processes</subject><subject>Lithium chloride</subject><subject>Lithium Chloride - administration & dosage</subject><subject>Male</subject><subject>Memory - physiology</subject><subject>Microdialysis</subject><subject>N-Methyl-D-aspartic acid receptors</subject><subject>Neurology</subject><subject>Neurotransmitters</subject><subject>Norepinephrine</subject><subject>Norepinephrine - metabolism</subject><subject>Propranolol - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reading Skills</subject><subject>Saccharin - administration & dosage</subject><subject>Science Education</subject><subject>Short Term Memory</subject><subject>Taste - drug effects</subject><subject>Taste aversion</subject><subject>Valine - analogs & derivatives</subject><subject>Valine - pharmacology</subject><issn>1072-0502</issn><issn>1549-5485</issn><issn>1549-5485</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1P3DAQhq2qqFDaY2-o8pFL6Nix481xtQK6iNKqoudokoyLkRMvdrLSij9fr5Zy5jIfmkfvaOZl7IuACyFAfPPDBUhloMyteMdOhFZ1odVCv881GFmABnnMPqb0CADGKPGBHUupF7U09Ql7_hXSVCy7p9klN7kw8t_kCRPxYPm1nycccCKOY8_vQqSNG2nzEHPkbuTTA_HlsPvbo0e-Tnw9boPfUr-f3WOaqFhuKaa96g8aQtzxVRhT8K7H_apP7MiiT_T5JZ-yP1eX96vvxe3P6_VqeVt0SsupQDTSGg22bqsWlTS277sWeguYb-2UbEUlAYVGLWqj6lJAWdmKdAsgtbHlKTs_6G5ieJopTc3gUkfe40hhTo0ACQu1gFK_ARUq_7kSZUaLA9rFkFIk22yiGzDuMtTsrWn80Bysya3I_NcX6bkdqH-l_3uRgbMDQNF1r-PLm9qUJov8A7JZkws</recordid><startdate>20120515</startdate><enddate>20120515</enddate><creator>Guzman-Ramos, Kioko</creator><creator>Osorio-Gomez, Daniel</creator><creator>Moreno-Castilla, Perla</creator><creator>Bermudez-Rattoni, Federico</creator><general>Cold Spring Harbor Laboratory Press</general><scope>7SW</scope><scope>BJH</scope><scope>BNH</scope><scope>BNI</scope><scope>BNJ</scope><scope>BNO</scope><scope>ERI</scope><scope>PET</scope><scope>REK</scope><scope>WWN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20120515</creationdate><title>Post-Acquisition Release of Glutamate and Norepinephrine in the Amygdala Is Involved in Taste-Aversion Memory Consolidation</title><author>Guzman-Ramos, Kioko ; Osorio-Gomez, Daniel ; Moreno-Castilla, Perla ; Bermudez-Rattoni, Federico</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-aa72f750f9b6ba427fddcb0df0a549c42b1620a15a51974931036f6e5b00257f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adrenergic beta-Antagonists - pharmacology</topic><topic>Amygdala</topic><topic>Amygdala - drug effects</topic><topic>Amygdala - metabolism</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Area Under Curve</topic><topic>Avoidance Learning - physiology</topic><topic>Biochemistry</topic><topic>Conditioning, Classical - physiology</topic><topic>Data processing</topic><topic>Dopamine</topic><topic>Dopamine - metabolism</topic><topic>Emotional Experience</topic><topic>Emotions</topic><topic>Excitatory Amino Acid Antagonists - pharmacology</topic><topic>Experimental Psychology</topic><topic>Experiments</topic><topic>Glutamic acid</topic><topic>Glutamic Acid - metabolism</topic><topic>Glutamic acid receptors</topic><topic>Learning Processes</topic><topic>Lithium chloride</topic><topic>Lithium Chloride - administration & dosage</topic><topic>Male</topic><topic>Memory - physiology</topic><topic>Microdialysis</topic><topic>N-Methyl-D-aspartic acid receptors</topic><topic>Neurology</topic><topic>Neurotransmitters</topic><topic>Norepinephrine</topic><topic>Norepinephrine - metabolism</topic><topic>Propranolol - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reading Skills</topic><topic>Saccharin - administration & dosage</topic><topic>Science Education</topic><topic>Short Term Memory</topic><topic>Taste - drug effects</topic><topic>Taste aversion</topic><topic>Valine - analogs & derivatives</topic><topic>Valine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guzman-Ramos, Kioko</creatorcontrib><creatorcontrib>Osorio-Gomez, Daniel</creatorcontrib><creatorcontrib>Moreno-Castilla, Perla</creatorcontrib><creatorcontrib>Bermudez-Rattoni, Federico</creatorcontrib><collection>ERIC</collection><collection>ERIC (Ovid)</collection><collection>ERIC</collection><collection>ERIC</collection><collection>ERIC (Legacy Platform)</collection><collection>ERIC( SilverPlatter )</collection><collection>ERIC</collection><collection>ERIC PlusText (Legacy Platform)</collection><collection>Education Resources Information Center (ERIC)</collection><collection>ERIC</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Learning & memory (Cold Spring Harbor, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guzman-Ramos, Kioko</au><au>Osorio-Gomez, Daniel</au><au>Moreno-Castilla, Perla</au><au>Bermudez-Rattoni, Federico</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><ericid>EJ973770</ericid><atitle>Post-Acquisition Release of Glutamate and Norepinephrine in the Amygdala Is Involved in Taste-Aversion Memory Consolidation</atitle><jtitle>Learning & memory (Cold Spring Harbor, N.Y.)</jtitle><addtitle>Learn Mem</addtitle><date>2012-05-15</date><risdate>2012</risdate><volume>19</volume><issue>6</issue><spage>231</spage><epage>238</epage><pages>231-238</pages><issn>1072-0502</issn><issn>1549-5485</issn><eissn>1549-5485</eissn><abstract>Amygdala activity mediates the acquisition and consolidation of emotional experiences; we have recently shown that post-acquisition reactivation of this structure is necessary for the long-term storage of conditioned taste aversion (CTA). However, the specific neurotransmitters involved in such reactivation are not known. The aim of the present study was to investigate extracellular changes of glutamate, norepinephrine, and dopamine within the rat amygdala using in vivo microdialysis during the acquisition and 1-h post-acquisition of CTA paradigm. Microdialysis monitoring showed a significant norepinephrine increase related to novel taste exposure and a glutamate increase after gastric malaise induction by i.p. LiCl administration. Interestingly, we found a spontaneous concomitant increase of glutamate and norepinephrine, but not dopamine, 45 min after conditioning, suggesting the presence of aversive learning-dependent post-acquisition signals in the amygdala. These signals seem to be involved in CTA consolidation process, since post-trial blockade of N-methyl-D-aspartate or [beta]-adrenergic receptors impaired long- but not short-term memory. These data suggest that CTA long-term storage involves post-acquisition release of glutamate and norepinephrine in the amygdala.</abstract><cop>United States</cop><pub>Cold Spring Harbor Laboratory Press</pub><pmid>22589279</pmid><doi>10.1101/lm.024703.111</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Learning & memory (Cold Spring Harbor, N.Y.), 2012-05, Vol.19 (6), p.231-238 |
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| subjects | Adrenergic beta-Antagonists - pharmacology Amygdala Amygdala - drug effects Amygdala - metabolism Analysis of Variance Animals Area Under Curve Avoidance Learning - physiology Biochemistry Conditioning, Classical - physiology Data processing Dopamine Dopamine - metabolism Emotional Experience Emotions Excitatory Amino Acid Antagonists - pharmacology Experimental Psychology Experiments Glutamic acid Glutamic Acid - metabolism Glutamic acid receptors Learning Processes Lithium chloride Lithium Chloride - administration & dosage Male Memory - physiology Microdialysis N-Methyl-D-aspartic acid receptors Neurology Neurotransmitters Norepinephrine Norepinephrine - metabolism Propranolol - pharmacology Rats Rats, Wistar Reading Skills Saccharin - administration & dosage Science Education Short Term Memory Taste - drug effects Taste aversion Valine - analogs & derivatives Valine - pharmacology |
| title | Post-Acquisition Release of Glutamate and Norepinephrine in the Amygdala Is Involved in Taste-Aversion Memory Consolidation |
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