Anthocyanin-rich extracts suppress the DNA-damaging effects of topoisomerase poisons in human colon cancer cells

Scope: The effect of two anthocyanin‐rich berry extracts (A, bilberry; B, red grape) on topoisomerases was investigated in a cell‐free system and in human HT29 colon carcinoma cells. In parallel, their impact on DNA integrity was determined. Methods and results: The berry extracts suppressed the act...

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Veröffentlicht in:	Molecular nutrition & food research 2011-05, Vol.55 (S1), p.S143-S153
Hauptverfasser:	Esselen, Melanie, Fritz, Jessica, Hutter, Melanie, Teller, Nicole, Baechler, Simone, Boettler, Ute, Marczylo, Tim H., Gescher, Andreas J., Marko, Doris
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthocyanins - pharmacology Antineoplastic Agents, Phytogenic - pharmacology Bilberry Camptothecin Camptothecin - pharmacology Cell-Free System Chemotherapy Colon cancer Colonic Neoplasms - drug therapy Comet assay DNA - drug effects DNA - metabolism DNA damage DNA Damage - drug effects DNA topoisomerase DNA topoisomerase (ATP-hydrolysing) DNA Topoisomerases, Type I - metabolism DNA Topoisomerases, Type II - metabolism Doxorubicin Doxorubicin - pharmacology Fruits HT29 Cells Humans ICE assay Plant Extracts - pharmacology Vaccinium myrtillus - chemistry Vitaceae
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