Involvement of TNF-α and MAPK pathway in the intramammary MMP-9 release via degranulation of cow neutrophils during acute mammary gland involution

Neutrophil-derived MMP-9 activity is regulated more promptly and efficiently at the level of degranulation than at other levels of regulation. In human neutrophils, degranulation is one of the earliest responses to TNF-α stimulation, which involves protein kinase C and mitogen-activating protein kin...

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Veröffentlicht in:	Veterinary immunology and immunopathology 2012-06, Vol.147 (3-4), p.161-169
Hauptverfasser:	Yu, Ting-Chieh, Chen, Shuen-Ei, Ho, Tsung-Hua, Peh, Huo-Cheng, Liu, Wen-Bor, Tiantong, Attapol, Nagahata, Hajime, Chang, Chai-Ju
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cattle - anatomy & histology Cattle - immunology Cattle - physiology Cell Degranulation - drug effects Cell Degranulation - physiology Cows Degranulation Dry period Female Humans In Vitro Techniques Involution Lactation - immunology Lactation - physiology Mammary gland Mammary Glands, Animal - anatomy & histology Mammary Glands, Animal - immunology Mammary Glands, Animal - physiology MAP Kinase Signaling System - drug effects MAPK pathway Matrix Metalloproteinase 9 - metabolism Milk - enzymology Milk - immunology MMP-9 Neutrophils Neutrophils - drug effects Neutrophils - physiology Protein Kinase Inhibitors - pharmacology TNF-α Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - metabolism Tumor Necrosis Factor-alpha - pharmacology
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