Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt-mTOR and MAPK signaling pathways in human leukemia HL-60 cells

Scope: Autophagy (type II programmed cell death) is crucial for maintaining cellular homeostasis. Several autophagy‐deficient or knockout studies indicate that autophagy is a tumor suppressor. Tetrahydrocurcumin (THC), a major metabolite of curcumin, has been demonstrated with anti‐colon carcinogene...

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Veröffentlicht in:	Molecular nutrition & food research 2011-11, Vol.55 (11), p.1646-1654
Hauptverfasser:	Wu, Jia-Ching, Lai, Ching-Shu, Badmaev, Vladimir, Nagabhushanam, Kalyanam, Ho, Chi-Tang, Pan, Min-Hsiung
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Adenine - analogs & derivatives Adenine - pharmacology AKT protein Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis Regulatory Proteins - metabolism Autophagy Autophagy - drug effects Beclin-1 Biological and medical sciences Carcinogenesis Cell death Cell Proliferation - drug effects Curcumin Curcumin - analogs & derivatives Curcumin - metabolism Curcumin - pharmacology Down-Regulation - drug effects Flow cytometry Food industries Fundamental and applied biological sciences. Psychology Glycogen synthase kinase 3 HL-60 Cells Homeostasis Humans Leukemia, Myeloid - drug therapy Leukemia, Myeloid - pathology MAP kinase MAP Kinase Signaling System - drug effects Membrane Proteins - metabolism Metabolites Microtubule-Associated Proteins - metabolism Neoplasm Proteins - metabolism Organelles Phagocytosis Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Phosphorylation - drug effects Promyeloid leukemia Protein Processing, Post-Translational - drug effects Proto-Oncogene Proteins c-akt - metabolism Ribosomal protein S6 kinase Signal transduction Signal Transduction - drug effects Tetrahydrocannabinol Tetrahydrocurcumin TOR protein TOR Serine-Threonine Kinases - metabolism Tumor suppressor genes Western blotting
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