Regulatory immune cells in transplantation
Key Points The presence of regulatory immune cells in transplant recipients can shift the balance away from rejection and towards immune regulation. Different populations of T cells with regulatory activity have a role in promoting transplant tolerance. These populations include CD4 + regulatory T (...
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| Veröffentlicht in: | Nature reviews. Immunology 2012-06, Vol.12 (6), p.417-430 |
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| creator | Wood, Kathryn J. Bushell, Andrew Hester, Joanna |
| description | Key Points
The presence of regulatory immune cells in transplant recipients can shift the balance away from rejection and towards immune regulation.
Different populations of T cells with regulatory activity have a role in promoting transplant tolerance. These populations include CD4
+
regulatory T (T
Reg
) cells, CD8
+
T
Reg
cells, CD4
−
CD8
−
T cells, natural killer T (NKT) cells and γδ T cells.
Control of allograft rejection and graft-versus-host disease (GVHD) can also be enhanced by various non-T cell leukocytes, including regulatory B cells, tolerogenic dendritic cells (DCs), regulatory macrophages, myeloid-derived suppressor cells (MDSCs) and mesenchymal stromal cells (MSCs).
Distinct regulatory cell populations are present in the draining lymphoid tissue and in the peripheral blood. These cells migrate to the allograft, where they modulate immune responses by inhibiting effector cells and by inducing other regulatory cells. Early after transplantation, MDSCs and MSCs can migrate to the site of an inflammatory response and promote the development of tolerogenic DCs and macrophages that induce peripheral T
Reg
cell development.
Cellular therapies using T
Reg
cells, regulatory macrophages and MSCs are being developed for clinical application to control rejection or GVHD in transplant recipients.
Establishing immune tolerance in transplant recipients is essential for promoting the long-term survival of an allograft and for preventing the development of harmful graft-versus-host responses. This Review considers the clinical potential of manipulating different immunosuppressive cell populations, including regulatory T cells, B cells and macrophages, in the setting of transplantation.
Immune regulation is fundamental to any immune response to ensure that it is appropriate for the perceived threat to the host. Following cell and organ transplantation, it is essential to control both the innate immune response triggered by the injured tissue and the adaptive immune response stimulated by mismatched donor and recipient histocompatibility antigens to enable the transplant to survive and function. Here, we discuss the leukocyte populations that can promote immune tolerance after cell or solid-organ transplantation. Such populations include regulatory T cells, B cells and macrophages, as well as myeloid-derived suppressor cells, dendritic cells and mesenchymal stromal cells. We consider the potential of these regulatory immune cells to develop and function in tr |
| doi_str_mv | 10.1038/nri3227 |
| format | Article |
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The presence of regulatory immune cells in transplant recipients can shift the balance away from rejection and towards immune regulation.
Different populations of T cells with regulatory activity have a role in promoting transplant tolerance. These populations include CD4
+
regulatory T (T
Reg
) cells, CD8
+
T
Reg
cells, CD4
−
CD8
−
T cells, natural killer T (NKT) cells and γδ T cells.
Control of allograft rejection and graft-versus-host disease (GVHD) can also be enhanced by various non-T cell leukocytes, including regulatory B cells, tolerogenic dendritic cells (DCs), regulatory macrophages, myeloid-derived suppressor cells (MDSCs) and mesenchymal stromal cells (MSCs).
Distinct regulatory cell populations are present in the draining lymphoid tissue and in the peripheral blood. These cells migrate to the allograft, where they modulate immune responses by inhibiting effector cells and by inducing other regulatory cells. Early after transplantation, MDSCs and MSCs can migrate to the site of an inflammatory response and promote the development of tolerogenic DCs and macrophages that induce peripheral T
Reg
cell development.
Cellular therapies using T
Reg
cells, regulatory macrophages and MSCs are being developed for clinical application to control rejection or GVHD in transplant recipients.
Establishing immune tolerance in transplant recipients is essential for promoting the long-term survival of an allograft and for preventing the development of harmful graft-versus-host responses. This Review considers the clinical potential of manipulating different immunosuppressive cell populations, including regulatory T cells, B cells and macrophages, in the setting of transplantation.
Immune regulation is fundamental to any immune response to ensure that it is appropriate for the perceived threat to the host. Following cell and organ transplantation, it is essential to control both the innate immune response triggered by the injured tissue and the adaptive immune response stimulated by mismatched donor and recipient histocompatibility antigens to enable the transplant to survive and function. Here, we discuss the leukocyte populations that can promote immune tolerance after cell or solid-organ transplantation. Such populations include regulatory T cells, B cells and macrophages, as well as myeloid-derived suppressor cells, dendritic cells and mesenchymal stromal cells. We consider the potential of these regulatory immune cells to develop and function in transplant recipients and their potential use as cellular therapies to promote long-term graft function.</description><identifier>ISSN: 1474-1733</identifier><identifier>EISSN: 1474-1741</identifier><identifier>DOI: 10.1038/nri3227</identifier><identifier>PMID: 22627860</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>40 ; 631/250/2504 ; 631/250/251 ; 692/698/1543/1565/1597 ; 692/700/565/545/576/402 ; Animals ; Antigens ; B cells ; Biomedical and Life Sciences ; Biomedicine ; Dendritic cells ; Donors ; Graft versus host disease ; Graft vs Host Disease - immunology ; Graft vs Host Disease - prevention & control ; Health aspects ; Histocompatibility ; HLA Antigens - immunology ; Humans ; Immune response ; Immune System - cytology ; Immune Tolerance - immunology ; Immunological tolerance ; Immunology ; Immunoregulation ; Immunosuppressive Agents - pharmacology ; Leukocytes ; Lymphocytes B ; Lymphocytes T ; Macrophages ; Mesenchyme ; Organ Transplantation - methods ; Physiological aspects ; review-article ; stromal cells ; Suppressor cells ; T cells ; Transplantation ; Transplantation Immunology ; Transplantation of organs, tissues, etc ; Transplants & implants</subject><ispartof>Nature reviews. Immunology, 2012-06, Vol.12 (6), p.417-430</ispartof><rights>Springer Nature Limited 2012</rights><rights>COPYRIGHT 2012 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jun 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-fb54dffaa9b82c7e6f6b60c2bae32ac9aaa00a9ad7535245aec3dcec3bb1b8813</citedby><cites>FETCH-LOGICAL-c540t-fb54dffaa9b82c7e6f6b60c2bae32ac9aaa00a9ad7535245aec3dcec3bb1b8813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22627860$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wood, Kathryn J.</creatorcontrib><creatorcontrib>Bushell, Andrew</creatorcontrib><creatorcontrib>Hester, Joanna</creatorcontrib><title>Regulatory immune cells in transplantation</title><title>Nature reviews. Immunology</title><addtitle>Nat Rev Immunol</addtitle><addtitle>Nat Rev Immunol</addtitle><description>Key Points
The presence of regulatory immune cells in transplant recipients can shift the balance away from rejection and towards immune regulation.
Different populations of T cells with regulatory activity have a role in promoting transplant tolerance. These populations include CD4
+
regulatory T (T
Reg
) cells, CD8
+
T
Reg
cells, CD4
−
CD8
−
T cells, natural killer T (NKT) cells and γδ T cells.
Control of allograft rejection and graft-versus-host disease (GVHD) can also be enhanced by various non-T cell leukocytes, including regulatory B cells, tolerogenic dendritic cells (DCs), regulatory macrophages, myeloid-derived suppressor cells (MDSCs) and mesenchymal stromal cells (MSCs).
Distinct regulatory cell populations are present in the draining lymphoid tissue and in the peripheral blood. These cells migrate to the allograft, where they modulate immune responses by inhibiting effector cells and by inducing other regulatory cells. Early after transplantation, MDSCs and MSCs can migrate to the site of an inflammatory response and promote the development of tolerogenic DCs and macrophages that induce peripheral T
Reg
cell development.
Cellular therapies using T
Reg
cells, regulatory macrophages and MSCs are being developed for clinical application to control rejection or GVHD in transplant recipients.
Establishing immune tolerance in transplant recipients is essential for promoting the long-term survival of an allograft and for preventing the development of harmful graft-versus-host responses. This Review considers the clinical potential of manipulating different immunosuppressive cell populations, including regulatory T cells, B cells and macrophages, in the setting of transplantation.
Immune regulation is fundamental to any immune response to ensure that it is appropriate for the perceived threat to the host. Following cell and organ transplantation, it is essential to control both the innate immune response triggered by the injured tissue and the adaptive immune response stimulated by mismatched donor and recipient histocompatibility antigens to enable the transplant to survive and function. Here, we discuss the leukocyte populations that can promote immune tolerance after cell or solid-organ transplantation. Such populations include regulatory T cells, B cells and macrophages, as well as myeloid-derived suppressor cells, dendritic cells and mesenchymal stromal cells. We consider the potential of these regulatory immune cells to develop and function in transplant recipients and their potential use as cellular therapies to promote long-term graft function.</description><subject>40</subject><subject>631/250/2504</subject><subject>631/250/251</subject><subject>692/698/1543/1565/1597</subject><subject>692/700/565/545/576/402</subject><subject>Animals</subject><subject>Antigens</subject><subject>B cells</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Dendritic cells</subject><subject>Donors</subject><subject>Graft versus host disease</subject><subject>Graft vs Host Disease - immunology</subject><subject>Graft vs Host Disease - prevention & control</subject><subject>Health aspects</subject><subject>Histocompatibility</subject><subject>HLA Antigens - immunology</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune System - cytology</subject><subject>Immune Tolerance - immunology</subject><subject>Immunological tolerance</subject><subject>Immunology</subject><subject>Immunoregulation</subject><subject>Immunosuppressive Agents - pharmacology</subject><subject>Leukocytes</subject><subject>Lymphocytes B</subject><subject>Lymphocytes T</subject><subject>Macrophages</subject><subject>Mesenchyme</subject><subject>Organ Transplantation - methods</subject><subject>Physiological aspects</subject><subject>review-article</subject><subject>stromal cells</subject><subject>Suppressor cells</subject><subject>T cells</subject><subject>Transplantation</subject><subject>Transplantation Immunology</subject><subject>Transplantation of organs, tissues, etc</subject><subject>Transplants & implants</subject><issn>1474-1733</issn><issn>1474-1741</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqN0m1L3TAUAOAwJvNt7B_IhYFO4bq8tEn78SLbFITBVT-X0_T0GmmTa5LC_PdL8e5qhx8k0ITmOYee00PIF0bPGRXFd-uN4Fx9IHssU9mcqYx93J6F2CX7ITxQymS6-UR2OZdcFZLukbMlroYOovNPM9P3g8WZxq4LM2Nn0YMN6w5shGicPSQ7LXQBP2_2A3L388ftxeX8-vevq4vF9VznGY3zts6zpm0ByrrgWqFsZS2p5jWg4KBLAKAUSmhULnKe5YBaNDo96prVRcHEAfn2nHft3eOAIVa9CeNHgUU3hIpRTouM55l6B2VSKlowmejX_-iDG7xNhYwqV6UqmXpRK-iwMrZ1qQl6TFoteMm5kKoQSZ2_odJqsDfaWWxNej8JOJ0EJBPxT1zBEEJ1dbOc2uNX9h6hi_fBdcP4C8IUnjxD7V0IHttq7U0P_ikVVI1TUW2mIsmjTe1D3WOzdf_G4KWPIV3ZFfrXzZnm-gujJLt3</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Wood, Kathryn J.</creator><creator>Bushell, Andrew</creator><creator>Hester, Joanna</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QR</scope><scope>7RV</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20120601</creationdate><title>Regulatory immune cells in transplantation</title><author>Wood, Kathryn J. ; Bushell, Andrew ; Hester, Joanna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-fb54dffaa9b82c7e6f6b60c2bae32ac9aaa00a9ad7535245aec3dcec3bb1b8813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>40</topic><topic>631/250/2504</topic><topic>631/250/251</topic><topic>692/698/1543/1565/1597</topic><topic>692/700/565/545/576/402</topic><topic>Animals</topic><topic>Antigens</topic><topic>B cells</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Dendritic cells</topic><topic>Donors</topic><topic>Graft versus host disease</topic><topic>Graft vs Host Disease - immunology</topic><topic>Graft vs Host Disease - prevention & control</topic><topic>Health aspects</topic><topic>Histocompatibility</topic><topic>HLA Antigens - immunology</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune System - cytology</topic><topic>Immune Tolerance - immunology</topic><topic>Immunological tolerance</topic><topic>Immunology</topic><topic>Immunoregulation</topic><topic>Immunosuppressive Agents - pharmacology</topic><topic>Leukocytes</topic><topic>Lymphocytes B</topic><topic>Lymphocytes T</topic><topic>Macrophages</topic><topic>Mesenchyme</topic><topic>Organ Transplantation - methods</topic><topic>Physiological aspects</topic><topic>review-article</topic><topic>stromal cells</topic><topic>Suppressor cells</topic><topic>T cells</topic><topic>Transplantation</topic><topic>Transplantation Immunology</topic><topic>Transplantation of organs, tissues, etc</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wood, Kathryn J.</creatorcontrib><creatorcontrib>Bushell, Andrew</creatorcontrib><creatorcontrib>Hester, Joanna</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Nature reviews. Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wood, Kathryn J.</au><au>Bushell, Andrew</au><au>Hester, Joanna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulatory immune cells in transplantation</atitle><jtitle>Nature reviews. Immunology</jtitle><stitle>Nat Rev Immunol</stitle><addtitle>Nat Rev Immunol</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>12</volume><issue>6</issue><spage>417</spage><epage>430</epage><pages>417-430</pages><issn>1474-1733</issn><eissn>1474-1741</eissn><abstract>Key Points
The presence of regulatory immune cells in transplant recipients can shift the balance away from rejection and towards immune regulation.
Different populations of T cells with regulatory activity have a role in promoting transplant tolerance. These populations include CD4
+
regulatory T (T
Reg
) cells, CD8
+
T
Reg
cells, CD4
−
CD8
−
T cells, natural killer T (NKT) cells and γδ T cells.
Control of allograft rejection and graft-versus-host disease (GVHD) can also be enhanced by various non-T cell leukocytes, including regulatory B cells, tolerogenic dendritic cells (DCs), regulatory macrophages, myeloid-derived suppressor cells (MDSCs) and mesenchymal stromal cells (MSCs).
Distinct regulatory cell populations are present in the draining lymphoid tissue and in the peripheral blood. These cells migrate to the allograft, where they modulate immune responses by inhibiting effector cells and by inducing other regulatory cells. Early after transplantation, MDSCs and MSCs can migrate to the site of an inflammatory response and promote the development of tolerogenic DCs and macrophages that induce peripheral T
Reg
cell development.
Cellular therapies using T
Reg
cells, regulatory macrophages and MSCs are being developed for clinical application to control rejection or GVHD in transplant recipients.
Establishing immune tolerance in transplant recipients is essential for promoting the long-term survival of an allograft and for preventing the development of harmful graft-versus-host responses. This Review considers the clinical potential of manipulating different immunosuppressive cell populations, including regulatory T cells, B cells and macrophages, in the setting of transplantation.
Immune regulation is fundamental to any immune response to ensure that it is appropriate for the perceived threat to the host. Following cell and organ transplantation, it is essential to control both the innate immune response triggered by the injured tissue and the adaptive immune response stimulated by mismatched donor and recipient histocompatibility antigens to enable the transplant to survive and function. Here, we discuss the leukocyte populations that can promote immune tolerance after cell or solid-organ transplantation. Such populations include regulatory T cells, B cells and macrophages, as well as myeloid-derived suppressor cells, dendritic cells and mesenchymal stromal cells. We consider the potential of these regulatory immune cells to develop and function in transplant recipients and their potential use as cellular therapies to promote long-term graft function.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>22627860</pmid><doi>10.1038/nri3227</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 40 631/250/2504 631/250/251 692/698/1543/1565/1597 692/700/565/545/576/402 Animals Antigens B cells Biomedical and Life Sciences Biomedicine Dendritic cells Donors Graft versus host disease Graft vs Host Disease - immunology Graft vs Host Disease - prevention & control Health aspects Histocompatibility HLA Antigens - immunology Humans Immune response Immune System - cytology Immune Tolerance - immunology Immunological tolerance Immunology Immunoregulation Immunosuppressive Agents - pharmacology Leukocytes Lymphocytes B Lymphocytes T Macrophages Mesenchyme Organ Transplantation - methods Physiological aspects review-article stromal cells Suppressor cells T cells Transplantation Transplantation Immunology Transplantation of organs, tissues, etc Transplants & implants |
| title | Regulatory immune cells in transplantation |
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