Definition and significance of high positivity aCL ELISA

We conducted a prospective study of anticardiolipin antibody (aCL) testing, performed in our university hospital. Among 6321 consecutive patients tested for both IgG and IgM aCL, 91 patients with medium or high positivity (>99th percentile) had a subsequent confirmatory test. Among them, 53 had a...

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Veröffentlicht in:	Lupus 2012-06, Vol.21 (7), p.725-726
Hauptverfasser:	Wahl, D, Devignes, J, Mohamed, S, Zuily, S, Lecompte, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anniversaries Antibodies Antibodies, Anticardiolipin - blood Antiphospholipid Syndrome - blood Antiphospholipid Syndrome - diagnosis Autoimmune diseases cardiolipin Disease Enzyme-Linked Immunosorbent Assay Female Hospitals Humans Immunoglobulin G Immunoglobulin M Lupus Male Middle Aged Prospective Studies Thrombosis Time Factors
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Beschreibung
Zusammenfassung:	We conducted a prospective study of anticardiolipin antibody (aCL) testing, performed in our university hospital. Among 6321 consecutive patients tested for both IgG and IgM aCL, 91 patients with medium or high positivity (>99th percentile) had a subsequent confirmatory test. Among them, 53 had a persistent positivity at 12 weeks. In this real world setting, patients with transient positivity had lower values than patients with persistent positivity.
ISSN:	0961-2033 1477-0962
DOI:	10.1177/0961203312443298