Building the niche: The role of the S100 proteins in metastatic growth
Abstract Communication between cancer cells and stromal cells, often mediated by extracellular molecules in the tumor microenvironment, plays a central role in tumorigenesis and metastasis. The establishment of a pro-inflammatory milieu is increasingly recognized as an important consequence of these...
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| Veröffentlicht in: | Seminars in cancer biology 2012-06, Vol.22 (3), p.216-225 |
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| container_title | Seminars in cancer biology |
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| creator | Lukanidin, Eugene Sleeman, Jonathan P |
| description | Abstract Communication between cancer cells and stromal cells, often mediated by extracellular molecules in the tumor microenvironment, plays a central role in tumorigenesis and metastasis. The establishment of a pro-inflammatory milieu is increasingly recognized as an important consequence of these interactions. The family of S100 Ca2+ -binding proteins has been implicated in many aspects of the interaction between cancer cells and stromal cells, and contributes to the formation of an inflammatory tumor microenvironment. Focusing on S100A4, S100A8 and S100A9, in this review we discuss the role these proteins play in primary tumors and in the development of metastases, in particular during the formation of pre-metastatic niches. |
| doi_str_mv | 10.1016/j.semcancer.2012.02.006 |
| format | Article |
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The establishment of a pro-inflammatory milieu is increasingly recognized as an important consequence of these interactions. The family of S100 Ca2+ -binding proteins has been implicated in many aspects of the interaction between cancer cells and stromal cells, and contributes to the formation of an inflammatory tumor microenvironment. 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The establishment of a pro-inflammatory milieu is increasingly recognized as an important consequence of these interactions. The family of S100 Ca2+ -binding proteins has been implicated in many aspects of the interaction between cancer cells and stromal cells, and contributes to the formation of an inflammatory tumor microenvironment. Focusing on S100A4, S100A8 and S100A9, in this review we discuss the role these proteins play in primary tumors and in the development of metastases, in particular during the formation of pre-metastatic niches.</description><subject>Calcium-binding protein</subject><subject>Cancer</subject><subject>Cell Transformation, Neoplastic - metabolism</subject><subject>Gene Expression</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - immunology</subject><subject>Inflammation - physiopathology</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Metastatic niche</subject><subject>Microenvironment</subject><subject>Microenvironments</subject><subject>Neoplasm Metastasis - physiopathology</subject><subject>Neoplasms - metabolism</subject><subject>S100 family</subject><subject>S100 protein</subject><subject>S100 Proteins - genetics</subject><subject>S100 Proteins - metabolism</subject><subject>S100A4 protein</subject><subject>stromal cells</subject><subject>Stromal Cells - metabolism</subject><subject>Tumor Microenvironment - physiology</subject><subject>Tumorigenesis</subject><issn>1044-579X</issn><issn>1096-3650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v1DAQxS0EoqXwFSBHLllmJraTcEBqKwpIlTi0SNwsrzPpesmfYjugfnsctvTAqdJIHlm_NzN6T4g3CBsE1O_2m8ijs5PjsCFA2kAu0E_EMUKry0oreLr2Upaqbr8fiRcx7gGglSifiyOiqsFK0bG4OFv80Pnppkg7Libvdvy-uM5tmAcu5v7v9xUCFLdhTuynWPipGDnZmGzyrrgJ8--0eyme9XaI_Or-PRHfLj5en38uL79--nJ-elk6RSqVFom3LemtamqsJGpX1Q2xlszdloE1OJS2azrLlaxJu6a3GnpNXd0rsk11It4e5uZrfi4ckxl9dDwMduJ5iQaBoJGgqH0EiorykhYzWh9QF-YYA_fmNvjRhrsMrZw2e_Pgt1n9NpALdFa-vl-ybEfuHnT_DM7A6QHg7Movn-XRec5zOh_YJdPN_hFLPvw3ww0-R2WHH3zHcT8vYcqmGzQxC8zVGvuaOlJOnFpd_QHpZahj</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Lukanidin, Eugene</creator><creator>Sleeman, Jonathan P</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TO</scope><scope>H94</scope></search><sort><creationdate>20120601</creationdate><title>Building the niche: The role of the S100 proteins in metastatic growth</title><author>Lukanidin, Eugene ; 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The establishment of a pro-inflammatory milieu is increasingly recognized as an important consequence of these interactions. The family of S100 Ca2+ -binding proteins has been implicated in many aspects of the interaction between cancer cells and stromal cells, and contributes to the formation of an inflammatory tumor microenvironment. Focusing on S100A4, S100A8 and S100A9, in this review we discuss the role these proteins play in primary tumors and in the development of metastases, in particular during the formation of pre-metastatic niches.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>22381352</pmid><doi>10.1016/j.semcancer.2012.02.006</doi><tpages>10</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Calcium-binding protein Cancer Cell Transformation, Neoplastic - metabolism Gene Expression Hematology, Oncology and Palliative Medicine Humans Inflammation Inflammation - immunology Inflammation - physiopathology Metastases Metastasis Metastatic niche Microenvironment Microenvironments Neoplasm Metastasis - physiopathology Neoplasms - metabolism S100 family S100 protein S100 Proteins - genetics S100 Proteins - metabolism S100A4 protein stromal cells Stromal Cells - metabolism Tumor Microenvironment - physiology Tumorigenesis |
| title | Building the niche: The role of the S100 proteins in metastatic growth |
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