Structure–Activity Relationship Study of Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitor 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101) and Absolute Configurational Assignment Using Infrared and Vibrational Circular Dichroism Spectroscopy in Combination with ab Initio Hartree–Fock Calculations

The excitatory amino acid transporters (EAATs) play essential roles in regulating the synaptic concentration of the neurotransmitter glutamate in the mammalian central nervous system. To date, five subtypes have been identified, named EAAT1–5 in humans, and GLAST, GLT-1, EAAC1, EAAT4, and EAAT5 in r...

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Veröffentlicht in:	Journal of medicinal chemistry 2012-06, Vol.55 (11), p.5403-5412
Hauptverfasser:	Huynh, Tri H. V, Shim, Irene, Bohr, Henrik, Abrahamsen, Bjarke, Nielsen, Birgitte, Jensen, Anders A, Bunch, Lennart
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspartic Acid - metabolism Benzopyrans - chemical synthesis Benzopyrans - chemistry Benzopyrans - pharmacology Circular Dichroism Excitatory Amino Acid Transporter 1 - antagonists & inhibitors HEK293 Cells Humans Models, Molecular Molecular Conformation Spectroscopy, Fourier Transform Infrared Stereoisomerism Structure-Activity Relationship Transition Temperature
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