Effects of coumestrol administration to maternal mice during pregnancy and lactation on renal Ca metabolism in neonatal mice
The present study was conducted to clarify the effects of coumestrol administration to maternal mice during pregnancy and lactation on serum Ca and Ca metabolism in their neonatal mice. From 6.5 to 16.5 days post coitus and from 3 to 10 days after parturition, maternal mice were administered at 200 ...
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| Veröffentlicht in: | Animal science journal 2012-06, Vol.83 (6), p.469-473 |
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| creator | UEDA, Michihisa HORIGUCHI, Yoshihiro SUGIMOTO, Miki IKEDA, Shuntaro KUME, Shinichi |
| description | The present study was conducted to clarify the effects of coumestrol administration to maternal mice during pregnancy and lactation on serum Ca and Ca metabolism in their neonatal mice. From 6.5 to 16.5 days post coitus and from 3 to 10 days after parturition, maternal mice were administered at 200 µg/kg body weight/day of coumestrol. Coumestrol administration did not affect weight gains, serum Ca and the expression of vitamin D receptor (VDR) protein in the kidney of neonatal mice, but weight gains of maternal mice were decreased by coumestrol administration. Coumestrol administration increased the messenger RNA (mRNA) expressions of epithelial Ca channels 1 (ECaC1) and VDR in the kidney of neonatal mice, and also increased the mRNA expressions of ECaC2 in the kidney and small intestine of male neonatal mice. The mRNA expressions of ECaC1, ECaC2, calbindin‐D9k (CaBP‐9k) and estrogen receptor (ER)α in the kidney and VDR in the small intestine of male neonatal mice were higher than those of female mice. Thus, coumestrol administration to maternal mice during pregnancy and lactation may affect renal Ca metabolism in neonatal mice, especially male neonatal mice via maternal milk. |
| doi_str_mv | 10.1111/j.1740-0929.2011.00977.x |
| format | Article |
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From 6.5 to 16.5 days post coitus and from 3 to 10 days after parturition, maternal mice were administered at 200 µg/kg body weight/day of coumestrol. Coumestrol administration did not affect weight gains, serum Ca and the expression of vitamin D receptor (VDR) protein in the kidney of neonatal mice, but weight gains of maternal mice were decreased by coumestrol administration. Coumestrol administration increased the messenger RNA (mRNA) expressions of epithelial Ca channels 1 (ECaC1) and VDR in the kidney of neonatal mice, and also increased the mRNA expressions of ECaC2 in the kidney and small intestine of male neonatal mice. The mRNA expressions of ECaC1, ECaC2, calbindin‐D9k (CaBP‐9k) and estrogen receptor (ER)α in the kidney and VDR in the small intestine of male neonatal mice were higher than those of female mice. Thus, coumestrol administration to maternal mice during pregnancy and lactation may affect renal Ca metabolism in neonatal mice, especially male neonatal mice via maternal milk.</description><identifier>ISSN: 1344-3941</identifier><identifier>EISSN: 1740-0929</identifier><identifier>DOI: 10.1111/j.1740-0929.2011.00977.x</identifier><identifier>PMID: 22694330</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Animal reproduction ; Animal sciences ; Animals ; Animals, Newborn - blood ; Animals, Newborn - metabolism ; Ca metabolism ; Calbindins ; Calcium - blood ; Calcium - metabolism ; calcium channels ; Calcium Channels - genetics ; Calcium Channels - metabolism ; coumestrol ; Coumestrol - pharmacology ; Estrogen Receptor alpha - genetics ; Estrogen Receptor alpha - metabolism ; Female ; gene expression ; Intestine, Small - metabolism ; Kidney - drug effects ; Kidney - metabolism ; kidneys ; lactation ; Lactation - drug effects ; Male ; maternal milk ; Maternal-Fetal Exchange - physiology ; messenger RNA ; Metabolism ; Mice ; Mice, Inbred ICR ; neonatal mice ; neonates ; parturition ; Phytoestrogens - pharmacology ; Pregnancy ; Pregnancy, Animal - physiology ; Receptors, Calcitriol - genetics ; Receptors, Calcitriol - metabolism ; RNA, Messenger - metabolism ; Rodents ; S100 Calcium Binding Protein G - genetics ; S100 Calcium Binding Protein G - metabolism ; small intestine ; TRPV Cation Channels - genetics ; TRPV Cation Channels - metabolism ; vitamin D ; vitamin D receptor ; weight gain ; Weight Gain - drug effects</subject><ispartof>Animal science journal, 2012-06, Vol.83 (6), p.469-473</ispartof><rights>2011 The Authors. Animal Science Journal © 2011 Japanese Society of Animal Science</rights><rights>2011 The Authors. Animal Science Journal © 2011 Japanese Society of Animal Science.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5987-f6aed089baa7d3c6274e0bb0ffc23bc6c7b0ad241dacf3deee7950714e50ac13</citedby><cites>FETCH-LOGICAL-c5987-f6aed089baa7d3c6274e0bb0ffc23bc6c7b0ad241dacf3deee7950714e50ac13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1740-0929.2011.00977.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1740-0929.2011.00977.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22694330$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>UEDA, Michihisa</creatorcontrib><creatorcontrib>HORIGUCHI, Yoshihiro</creatorcontrib><creatorcontrib>SUGIMOTO, Miki</creatorcontrib><creatorcontrib>IKEDA, Shuntaro</creatorcontrib><creatorcontrib>KUME, Shinichi</creatorcontrib><title>Effects of coumestrol administration to maternal mice during pregnancy and lactation on renal Ca metabolism in neonatal mice</title><title>Animal science journal</title><addtitle>Anim Sci J</addtitle><description>The present study was conducted to clarify the effects of coumestrol administration to maternal mice during pregnancy and lactation on serum Ca and Ca metabolism in their neonatal mice. From 6.5 to 16.5 days post coitus and from 3 to 10 days after parturition, maternal mice were administered at 200 µg/kg body weight/day of coumestrol. Coumestrol administration did not affect weight gains, serum Ca and the expression of vitamin D receptor (VDR) protein in the kidney of neonatal mice, but weight gains of maternal mice were decreased by coumestrol administration. Coumestrol administration increased the messenger RNA (mRNA) expressions of epithelial Ca channels 1 (ECaC1) and VDR in the kidney of neonatal mice, and also increased the mRNA expressions of ECaC2 in the kidney and small intestine of male neonatal mice. The mRNA expressions of ECaC1, ECaC2, calbindin‐D9k (CaBP‐9k) and estrogen receptor (ER)α in the kidney and VDR in the small intestine of male neonatal mice were higher than those of female mice. Thus, coumestrol administration to maternal mice during pregnancy and lactation may affect renal Ca metabolism in neonatal mice, especially male neonatal mice via maternal milk.</description><subject>Animal reproduction</subject><subject>Animal sciences</subject><subject>Animals</subject><subject>Animals, Newborn - blood</subject><subject>Animals, Newborn - metabolism</subject><subject>Ca metabolism</subject><subject>Calbindins</subject><subject>Calcium - blood</subject><subject>Calcium - metabolism</subject><subject>calcium channels</subject><subject>Calcium Channels - genetics</subject><subject>Calcium Channels - metabolism</subject><subject>coumestrol</subject><subject>Coumestrol - pharmacology</subject><subject>Estrogen Receptor alpha - genetics</subject><subject>Estrogen Receptor alpha - metabolism</subject><subject>Female</subject><subject>gene expression</subject><subject>Intestine, Small - metabolism</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>kidneys</subject><subject>lactation</subject><subject>Lactation - drug effects</subject><subject>Male</subject><subject>maternal milk</subject><subject>Maternal-Fetal Exchange - physiology</subject><subject>messenger RNA</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>neonatal mice</subject><subject>neonates</subject><subject>parturition</subject><subject>Phytoestrogens - pharmacology</subject><subject>Pregnancy</subject><subject>Pregnancy, Animal - physiology</subject><subject>Receptors, Calcitriol - genetics</subject><subject>Receptors, Calcitriol - metabolism</subject><subject>RNA, Messenger - metabolism</subject><subject>Rodents</subject><subject>S100 Calcium Binding Protein G - genetics</subject><subject>S100 Calcium Binding Protein G - metabolism</subject><subject>small intestine</subject><subject>TRPV Cation Channels - genetics</subject><subject>TRPV Cation Channels - metabolism</subject><subject>vitamin D</subject><subject>vitamin D receptor</subject><subject>weight gain</subject><subject>Weight Gain - drug effects</subject><issn>1344-3941</issn><issn>1740-0929</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUFv1DAUhCMEoqXwF8ASFy4Jz3YSJxKXaimFqgKVFvVovTjOyktiL3YidqX--Dpk2QMnLEseyd-M_TRJQihkNK73m4yKHFKoWZ0xoDQDqIXIdk-S0-PF06h5nqe8zulJ8iKEDQAVNRTPkxPGyjrnHE6Th4uu02oMxHVEuWnQYfSuJ9gOxpqocTTOktGRAUftLfZkMEqTdvLGrsnW67VFq_YEbUt6VOPCx-31DK-QDHrExvUmDMRYYrWzOB5iXibPOuyDfnU4z5K7Txd3q8_p9bfLL6vz61QVdSXSrkTdQlU3iKLlqmQi19A00HWK8UaVSjSALctpi6rjrdZa1AUImusCUFF-lrxbYrfe_ZrihHIwQem-x_ibKUgKDCrOWFFF9O0_6MZN89gLRcui5BCpaqGUdyF43cmtNwP6fYTkXJDcyLkHOfcg54Lkn4LkLlpfHx6YmkG3R-PfRiLwYQF-m17v_ztYnt9eRRHt6WKP5end0Y7-pywFF4W8_3opP94Avb-qbuT3yL9Z-A6dxLU3Qf64jcE5ABRlzgR_BN6vuRM</recordid><startdate>201206</startdate><enddate>201206</enddate><creator>UEDA, Michihisa</creator><creator>HORIGUCHI, Yoshihiro</creator><creator>SUGIMOTO, Miki</creator><creator>IKEDA, Shuntaro</creator><creator>KUME, Shinichi</creator><general>Blackwell Publishing Asia</general><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201206</creationdate><title>Effects of coumestrol administration to maternal mice during pregnancy and lactation on renal Ca metabolism in neonatal mice</title><author>UEDA, Michihisa ; HORIGUCHI, Yoshihiro ; SUGIMOTO, Miki ; IKEDA, Shuntaro ; KUME, Shinichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5987-f6aed089baa7d3c6274e0bb0ffc23bc6c7b0ad241dacf3deee7950714e50ac13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animal reproduction</topic><topic>Animal sciences</topic><topic>Animals</topic><topic>Animals, Newborn - blood</topic><topic>Animals, Newborn - metabolism</topic><topic>Ca metabolism</topic><topic>Calbindins</topic><topic>Calcium - blood</topic><topic>Calcium - metabolism</topic><topic>calcium channels</topic><topic>Calcium Channels - genetics</topic><topic>Calcium Channels - metabolism</topic><topic>coumestrol</topic><topic>Coumestrol - pharmacology</topic><topic>Estrogen Receptor alpha - genetics</topic><topic>Estrogen Receptor alpha - metabolism</topic><topic>Female</topic><topic>gene expression</topic><topic>Intestine, Small - metabolism</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>kidneys</topic><topic>lactation</topic><topic>Lactation - drug effects</topic><topic>Male</topic><topic>maternal milk</topic><topic>Maternal-Fetal Exchange - physiology</topic><topic>messenger RNA</topic><topic>Metabolism</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>neonatal mice</topic><topic>neonates</topic><topic>parturition</topic><topic>Phytoestrogens - pharmacology</topic><topic>Pregnancy</topic><topic>Pregnancy, Animal - physiology</topic><topic>Receptors, Calcitriol - genetics</topic><topic>Receptors, Calcitriol - metabolism</topic><topic>RNA, Messenger - metabolism</topic><topic>Rodents</topic><topic>S100 Calcium Binding Protein G - genetics</topic><topic>S100 Calcium Binding Protein G - metabolism</topic><topic>small intestine</topic><topic>TRPV Cation Channels - genetics</topic><topic>TRPV Cation Channels - metabolism</topic><topic>vitamin D</topic><topic>vitamin D receptor</topic><topic>weight gain</topic><topic>Weight Gain - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>UEDA, Michihisa</creatorcontrib><creatorcontrib>HORIGUCHI, Yoshihiro</creatorcontrib><creatorcontrib>SUGIMOTO, Miki</creatorcontrib><creatorcontrib>IKEDA, Shuntaro</creatorcontrib><creatorcontrib>KUME, Shinichi</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Animal science journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>UEDA, Michihisa</au><au>HORIGUCHI, Yoshihiro</au><au>SUGIMOTO, Miki</au><au>IKEDA, Shuntaro</au><au>KUME, Shinichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of coumestrol administration to maternal mice during pregnancy and lactation on renal Ca metabolism in neonatal mice</atitle><jtitle>Animal science journal</jtitle><addtitle>Anim Sci J</addtitle><date>2012-06</date><risdate>2012</risdate><volume>83</volume><issue>6</issue><spage>469</spage><epage>473</epage><pages>469-473</pages><issn>1344-3941</issn><eissn>1740-0929</eissn><abstract>The present study was conducted to clarify the effects of coumestrol administration to maternal mice during pregnancy and lactation on serum Ca and Ca metabolism in their neonatal mice. From 6.5 to 16.5 days post coitus and from 3 to 10 days after parturition, maternal mice were administered at 200 µg/kg body weight/day of coumestrol. Coumestrol administration did not affect weight gains, serum Ca and the expression of vitamin D receptor (VDR) protein in the kidney of neonatal mice, but weight gains of maternal mice were decreased by coumestrol administration. Coumestrol administration increased the messenger RNA (mRNA) expressions of epithelial Ca channels 1 (ECaC1) and VDR in the kidney of neonatal mice, and also increased the mRNA expressions of ECaC2 in the kidney and small intestine of male neonatal mice. The mRNA expressions of ECaC1, ECaC2, calbindin‐D9k (CaBP‐9k) and estrogen receptor (ER)α in the kidney and VDR in the small intestine of male neonatal mice were higher than those of female mice. Thus, coumestrol administration to maternal mice during pregnancy and lactation may affect renal Ca metabolism in neonatal mice, especially male neonatal mice via maternal milk.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>22694330</pmid><doi>10.1111/j.1740-0929.2011.00977.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Animal science journal, 2012-06, Vol.83 (6), p.469-473 |
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| subjects | Animal reproduction Animal sciences Animals Animals, Newborn - blood Animals, Newborn - metabolism Ca metabolism Calbindins Calcium - blood Calcium - metabolism calcium channels Calcium Channels - genetics Calcium Channels - metabolism coumestrol Coumestrol - pharmacology Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Female gene expression Intestine, Small - metabolism Kidney - drug effects Kidney - metabolism kidneys lactation Lactation - drug effects Male maternal milk Maternal-Fetal Exchange - physiology messenger RNA Metabolism Mice Mice, Inbred ICR neonatal mice neonates parturition Phytoestrogens - pharmacology Pregnancy Pregnancy, Animal - physiology Receptors, Calcitriol - genetics Receptors, Calcitriol - metabolism RNA, Messenger - metabolism Rodents S100 Calcium Binding Protein G - genetics S100 Calcium Binding Protein G - metabolism small intestine TRPV Cation Channels - genetics TRPV Cation Channels - metabolism vitamin D vitamin D receptor weight gain Weight Gain - drug effects |
| title | Effects of coumestrol administration to maternal mice during pregnancy and lactation on renal Ca metabolism in neonatal mice |
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