Kavalactones and the endocannabinoid system: The plant-derived yangonin is a novel CB1 receptor ligand

To investigate the possible interactions between kavalactone-based molecules and proteins of the endocannabinoid system and provide novel and synthetically accessible structural scaffolds for the design of cannabinoid receptor ligands sharing pharmacological properties with kavapyrones, a preliminar...

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Veröffentlicht in:	Pharmacological research 2012-08, Vol.66 (2), p.163-169
Hauptverfasser:	Ligresti, Alessia, Villano, Rosaria, Allarà, Marco, Ujváry, István, Di Marzo, Vincenzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases - antagonists & inhibitors Animals Binding, Competitive Cannabinoid Cannabinoid Receptor Modulators - metabolism Cannabinoid receptors CB1 CB2 Endocannabinoid Endocannabinoids Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology FAAH HEK293 Cells Humans Kava Ligands MAGL Monoacylglycerol Lipases - antagonists & inhibitors Natural products Piper Pyrans - chemical synthesis Pyrans - chemistry Pyrans - pharmacology Pyrones - chemical synthesis Pyrones - chemistry Pyrones - pharmacology Rats Receptor, Cannabinoid, CB1 - metabolism Receptor, Cannabinoid, CB2 - metabolism Structure-Activity Relationship
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