Characterization of the renal CD4+ T-cell response in experimental autoimmune glomerulonephritis

Autoimmunity against the Goodpasture antigen α3IV-NC1 results in antiglomerular basement membrane glomerulonephritis. Although antibodies are central to the pathogenesis, there is good evidence for the participation of T cells in this disease. To define the contribution of T cells, we used the model...

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Veröffentlicht in:	Kidney international 2012-07, Vol.82 (1), p.60-71
Hauptverfasser:	Hopfer, Helmut, Holzer, Julia, Hünemörder, Stefanie, Paust, Hans-Joachim, Sachs, Marlies, Meyer-Schwesinger, Catherine, Turner, Jan-Eric, Panzer, Ulf, Mittrücker, Hans-Willi
Format:	Artikel
Sprache:	eng
Schlagworte:	Albuminuria - immunology Animals anti-GBM disease Anti-Glomerular Basement Membrane Disease - blood Anti-Glomerular Basement Membrane Disease - immunology Anti-Glomerular Basement Membrane Disease - pathology Anti-Glomerular Basement Membrane Disease - physiopathology Antibodies - blood Autoantigens Biological and medical sciences CD4-Positive T-Lymphocytes - immunology Chemotaxis Collagen Type IV Disease Models, Animal Disease Progression Glomerulonephritis Goodpasture's syndrome Humans immunology and pathology Interferon-gamma - metabolism Kidney - immunology Kidney - pathology Kidney - physiopathology Lymphocyte Activation lymphocytes Macrophages - immunology Male Medical sciences Mice Mice, Inbred DBA Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Phenotype renal injury Th1 Cells - immunology Th17 Cells - immunology Time Factors
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