Stearic Acid Accumulation in Macrophages Induces Toll-Like Receptor 4/2-Independent Inflammation Leading to Endoplasmic Reticulum Stress–Mediated Apoptosis

OBJECTIVE—Elevated serum free fatty acid levels are associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus. Macrophages are recruited to atherosclerotic plaques and metabolic tissues during obesity and accumulate lipids, including free fatty acids. We investigated t...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2012-07, Vol.32 (7), p.1687-1695
Hauptverfasser:	Anderson, Emily K, Hill, Andrea A, Hasty, Alyssa H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cell Polarity Endoplasmic Reticulum Stress - physiology Inflammation - etiology Macrophages - metabolism Mice Mice, Inbred C57BL Stearic Acids - metabolism Toll-Like Receptor 2 - physiology Toll-Like Receptor 4 - physiology
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