Cell Surface-Anchored Fluorescent Aptamer Sensor Enables Imaging of Chemical Transmitter Dynamics

A fluorescent aptamer sensor was applied to the analysis of extracellular chemical transmitter dynamics. We utilized a tocopherol-labeled aptamer, which allowed the direct anchoring of the fluorescent aptamer on the cell surface while retaining its performance as a fluorescent sensor. The fast-respo...

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Veröffentlicht in:	Journal of the American Chemical Society 2012-06, Vol.134 (23), p.9561-9564
Hauptverfasser:	Tokunaga, Takeshi, Namiki, Shigeyuki, Yamada, Katsuhiro, Imaishi, Takahiro, Nonaka, Hiroshi, Hirose, Kenzo, Sando, Shinsuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analysis Adenine - metabolism Animals Aptamers, Nucleotide - chemistry Astrocytes - cytology Astrocytes - metabolism Biosensing Techniques - methods Brain - cytology Calcium Signaling Cells, Cultured Fluorescent Dyes - chemistry HeLa Cells Humans Microscopy, Fluorescence - methods Models, Molecular Rats Tocopherols - chemistry
Online-Zugang:	Volltext
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