Significant Association between Hand-Foot Syndrome and Efficacy of Capecitabine in Patients with Metastatic Breast Cancer

Capecitabine, an oral prodrug of 5-fluorouracil (5-FU), is a promising treatment for colorectal, breast and gastric cancers, but often causes hand-foot syndrome (HFS), the most common dose-limiting toxicity. The current study was conducted to investigate the relationship between HFS and efficacy of...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2012/05/01, Vol.35(5), pp.717-724
Hauptverfasser:	Azuma, Yuichiro, Hata, Kojiro, Sai, Kimie, Udagawa, Ryoko, Hirakawa, Akihiro, Tohkin, Masahiro, Ryushima, Yasuaki, Makino, Yoshinori, Yokote, Nobuaki, Morikawa, Norifumi, Fujiwara, Yasuhiro, Saito, Yoshiro, Yamamoto, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antimetabolites, Antineoplastic - adverse effects Antimetabolites, Antineoplastic - therapeutic use Biomarkers, Tumor - blood Breast Neoplasms - blood Breast Neoplasms - drug therapy Breast Neoplasms - pathology Capecitabine Confidence Intervals Deoxycytidine - adverse effects Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use efficacy electronic medical record Female Fluorouracil - adverse effects Fluorouracil - analogs & derivatives Fluorouracil - therapeutic use hand-foot syndrome Hand-Foot Syndrome - etiology Humans Liver Neoplasms - blood Liver Neoplasms - drug therapy Liver Neoplasms - secondary Middle Aged Prodrugs - adverse effects Prodrugs - therapeutic use Proportional Hazards Models Retrospective Studies Treatment Outcome
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