Platelet transfusion alters CD40L blood level and release capacity in patients suffering from thrombocytopenia

BACKGROUND: Platelet (PLT)‐derived cytokines, such as soluble CD40 ligand (sCD40L), play an important role in the development of adverse transfusion reactions associated with the administration of PLT products. In this study, we determined sCD40L concentration and release capacity in patients with t...

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Veröffentlicht in:	Transfusion (Philadelphia, Pa.) Pa.), 2012-06, Vol.52 (6), p.1213-1220
Hauptverfasser:	Wenzel, Folker, Günther, Wiebke, Baertl, Anja, Gruber, Wolfgang, Sorg, Rüdiger Volker, Haas, Rainer, Giers, Günther
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Blood coagulation. Blood cells Blood Donors Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Case-Control Studies CD40 Ligand - blood CD40 Ligand - secretion Female Fundamental and applied biological sciences. Psychology Humans Male Medical sciences Middle Aged Molecular and cellular biology Neoplasms - drug therapy Platelet Platelet Count Platelet Transfusion - adverse effects Plateletpheresis Thrombocytopenia - blood Thrombocytopenia - chemically induced Thrombocytopenia - metabolism Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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