2′-Benzoyloxycinnamaldehyde-Mediated DJ-1 Upregulation Protects MCF-7 Cells from Mitochondrial Damage

2′-Benzoyloxycinnamaldehyde (BCA) is a promising antitumor agent which induces cancer cells apoptosis via reactive oxygen species (ROS) generation. BCA shows more effective antiproliferation in MDA-MB-435 than in MCF-7 breast cancer cells. DJ-1 has been known to protect cells against oxidative stres...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2012/06/01, Vol.35(6), pp.895-902
Hauptverfasser:	Ismail, Ismail Ahmed, Kang, Hye Suk, Lee, Heon-Jin, Kwon, Byoung-Mog, Hong, Su-Hyung
Format:	Artikel
Sprache:	eng
Schlagworte:	2′-benzoyloxycinnamaldehyde Acrolein - analogs & derivatives Acrolein - pharmacology Antineoplastic Agents - pharmacology Benzoates - pharmacology breast cancer cell Cell Cycle - drug effects Cell Line, Tumor Cell Survival - drug effects DJ-1 Gene Silencing Humans Intracellular Signaling Peptides and Proteins - genetics Membrane Potential, Mitochondrial - drug effects Mitochondria - drug effects Mitochondria - physiology mitochondrial membrane potential Oncogene Proteins - biosynthesis Oncogene Proteins - genetics Protein Deglycase DJ-1 RNA, Small Interfering - genetics Up-Regulation
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