HPLC-MS/MS method to determine genipin in rat plasma after hydrolysis with sulfatase and its application to a pharmacokinetic study

ABSTRACT A sensitive high‐performance liquid chromatography–tandem mass spectrometry (LC‐MS/MS) method was developed for the quantification of genipin in rat plasma after hydrolysis with sulfatase. Genipin could not be detected directly as it could be transformed into other forms such as conjugated‐...

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Veröffentlicht in:	Biomedical chromatography 2012-07, Vol.26 (7), p.816-825
Hauptverfasser:	Ding, Yue, Zhang, Tong, Tao, Jian-Sheng, Tan, Bo, Guo, Chun-Rong, Yang, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Benzoates Bridged-Ring Compounds Chromatography, High Pressure Liquid - methods Drug Stability genipin Glucosides HPLC-MS/MS Hydrolysis Injections, Intravenous Iridoids - administration & dosage Iridoids - blood Iridoids - pharmacokinetics Male Monoterpenes pharmacokinetics Rats Rats, Sprague-Dawley Reproducibility of Results Sensitivity and Specificity sulfatase Sulfatases - chemistry Sulfatases - metabolism Tandem Mass Spectrometry - methods
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