Phytochemical characterization and antinociceptive effect of Lippia gracilis Schauer
Lippia gracilis Schauer is an aromatic plant widely found in Northeastern Brazil. The leaf infusions or decoctions and alcoholic macerate are used for some inflammatory diseases and headache. This paper reports the isolation of naringenin by semi-preparative liquid chromatography from the methanolic...
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| Veröffentlicht in: | Journal of natural medicines 2012-07, Vol.66 (3), p.428-434 |
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| creator | Guimarães, Adriana G Gomes, Silvana V. F Moraes, Valéria R. S Nogueira, Paulo C. L Ferreira, Antônio G Blank, Arie F Santos, Alan D. C Viana, Monalisa D Silva, Geraldo H Quintans Júnior, Lucindo J |
| description | Lippia gracilis Schauer is an aromatic plant widely found in Northeastern Brazil. The leaf infusions or decoctions and alcoholic macerate are used for some inflammatory diseases and headache. This paper reports the isolation of naringenin by semi-preparative liquid chromatography from the methanolic extract of L. gracilis (ELg) and the evaluation of the analgesic and anti-inflammatory activities of this extract by measuring nociception through acetic acid, formalin, and hot-plate tests in carrageenan-induced inflammation in mice. Following oral administration, ELg (100, 200, and 400 mg/kg) significantly reduced the number of writhes in the writhing test and the time of paw licks in both phases of the formalin test when compared to the control group animals. Mice treated with ELg did not exhibit any behavioral alteration during the hot plate and rota-rod tests, suggesting non-participation of the supraspinal components in the modulation of pain by ELg and no motor abnormality. The oral administration of 400 mg/kg of ELg produced an anti-inflammatory effect on peritonitis induced by carrageenan. These effects can be associated with a decrease of inflammatory mediator synthesis by compounds of ELg, such as naringenin, which has anti-inflammatory action as already described. |
| doi_str_mv | 10.1007/s11418-011-0601-3 |
| format | Article |
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F ; Moraes, Valéria R. S ; Nogueira, Paulo C. L ; Ferreira, Antônio G ; Blank, Arie F ; Santos, Alan D. C ; Viana, Monalisa D ; Silva, Geraldo H ; Quintans Júnior, Lucindo J</creator><creatorcontrib>Guimarães, Adriana G ; Gomes, Silvana V. F ; Moraes, Valéria R. S ; Nogueira, Paulo C. L ; Ferreira, Antônio G ; Blank, Arie F ; Santos, Alan D. C ; Viana, Monalisa D ; Silva, Geraldo H ; Quintans Júnior, Lucindo J</creatorcontrib><description>Lippia gracilis Schauer is an aromatic plant widely found in Northeastern Brazil. The leaf infusions or decoctions and alcoholic macerate are used for some inflammatory diseases and headache. This paper reports the isolation of naringenin by semi-preparative liquid chromatography from the methanolic extract of L. gracilis (ELg) and the evaluation of the analgesic and anti-inflammatory activities of this extract by measuring nociception through acetic acid, formalin, and hot-plate tests in carrageenan-induced inflammation in mice. Following oral administration, ELg (100, 200, and 400 mg/kg) significantly reduced the number of writhes in the writhing test and the time of paw licks in both phases of the formalin test when compared to the control group animals. Mice treated with ELg did not exhibit any behavioral alteration during the hot plate and rota-rod tests, suggesting non-participation of the supraspinal components in the modulation of pain by ELg and no motor abnormality. The oral administration of 400 mg/kg of ELg produced an anti-inflammatory effect on peritonitis induced by carrageenan. These effects can be associated with a decrease of inflammatory mediator synthesis by compounds of ELg, such as naringenin, which has anti-inflammatory action as already described.</description><identifier>ISSN: 1340-3443</identifier><identifier>EISSN: 1861-0293</identifier><identifier>DOI: 10.1007/s11418-011-0601-3</identifier><identifier>PMID: 22146971</identifier><language>eng</language><publisher>Japan: Springer-Verlag</publisher><subject>acetic acid ; analgesic effect ; analgesics ; Analgesics - chemistry ; Analgesics - therapeutic use ; Animals ; anti-inflammatory activity ; Anti-Inflammatory Agents - chemistry ; Anti-Inflammatory Agents - therapeutic use ; Biomedical and Life Sciences ; Biomedicine ; Brazil ; carrageenan ; Complementary & Alternative Medicine ; formalin ; headache ; inflammation ; leaves ; Lippia ; Lippia - chemistry ; liquid chromatography ; Male ; Medicinal Chemistry ; Mice ; naringenin ; nociception ; oral administration ; Original Paper ; Pain - drug therapy ; peritonitis ; Pharmacology/Toxicology ; Pharmacy ; Plant Extracts - chemistry ; Plant Extracts - therapeutic use ; Plant Sciences</subject><ispartof>Journal of natural medicines, 2012-07, Vol.66 (3), p.428-434</ispartof><rights>The Japanese Society of Pharmacognosy and Springer 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-458a1079599c526a8745d829507915d933c4f17afaa29f36d45be474b1f42e553</citedby><cites>FETCH-LOGICAL-c485t-458a1079599c526a8745d829507915d933c4f17afaa29f36d45be474b1f42e553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11418-011-0601-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11418-011-0601-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22146971$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guimarães, Adriana G</creatorcontrib><creatorcontrib>Gomes, Silvana V. F</creatorcontrib><creatorcontrib>Moraes, Valéria R. S</creatorcontrib><creatorcontrib>Nogueira, Paulo C. L</creatorcontrib><creatorcontrib>Ferreira, Antônio G</creatorcontrib><creatorcontrib>Blank, Arie F</creatorcontrib><creatorcontrib>Santos, Alan D. C</creatorcontrib><creatorcontrib>Viana, Monalisa D</creatorcontrib><creatorcontrib>Silva, Geraldo H</creatorcontrib><creatorcontrib>Quintans Júnior, Lucindo J</creatorcontrib><title>Phytochemical characterization and antinociceptive effect of Lippia gracilis Schauer</title><title>Journal of natural medicines</title><addtitle>J Nat Med</addtitle><addtitle>J Nat Med</addtitle><description>Lippia gracilis Schauer is an aromatic plant widely found in Northeastern Brazil. The leaf infusions or decoctions and alcoholic macerate are used for some inflammatory diseases and headache. This paper reports the isolation of naringenin by semi-preparative liquid chromatography from the methanolic extract of L. gracilis (ELg) and the evaluation of the analgesic and anti-inflammatory activities of this extract by measuring nociception through acetic acid, formalin, and hot-plate tests in carrageenan-induced inflammation in mice. Following oral administration, ELg (100, 200, and 400 mg/kg) significantly reduced the number of writhes in the writhing test and the time of paw licks in both phases of the formalin test when compared to the control group animals. Mice treated with ELg did not exhibit any behavioral alteration during the hot plate and rota-rod tests, suggesting non-participation of the supraspinal components in the modulation of pain by ELg and no motor abnormality. The oral administration of 400 mg/kg of ELg produced an anti-inflammatory effect on peritonitis induced by carrageenan. These effects can be associated with a decrease of inflammatory mediator synthesis by compounds of ELg, such as naringenin, which has anti-inflammatory action as already described.</description><subject>acetic acid</subject><subject>analgesic effect</subject><subject>analgesics</subject><subject>Analgesics - chemistry</subject><subject>Analgesics - therapeutic use</subject><subject>Animals</subject><subject>anti-inflammatory activity</subject><subject>Anti-Inflammatory Agents - chemistry</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brazil</subject><subject>carrageenan</subject><subject>Complementary & Alternative Medicine</subject><subject>formalin</subject><subject>headache</subject><subject>inflammation</subject><subject>leaves</subject><subject>Lippia</subject><subject>Lippia - chemistry</subject><subject>liquid chromatography</subject><subject>Male</subject><subject>Medicinal Chemistry</subject><subject>Mice</subject><subject>naringenin</subject><subject>nociception</subject><subject>oral administration</subject><subject>Original Paper</subject><subject>Pain - drug therapy</subject><subject>peritonitis</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Sciences</subject><issn>1340-3443</issn><issn>1861-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1O3DAUha2qqPw-QDdtlt0E7rWv87OsEBSkkUAC1pbHsWeMMnFqJ0jD02MU2iULy772d47kj7HvCOcIUF8kRMKmBMQSKsBSfGFH2FR54q34ms-CoBRE4pAdp_QMQFwI_MYOOUeq2hqP2OP9dj8Fs7U7b3RfmK2O2kw2-lc9-TAUeujymvwQjDd2nPyLLaxz1kxFcMXKj6PXxSZnfO9T8ZDzs42n7MDpPtmzj_2EPV1fPV7elKu7P7eXv1eloUZOJclGI9StbFsjeaWbmmTX8FbmO5RdK4Qhh7V2WvPWiaojubZU0xodcSulOGG_lt4xhr-zTZPa-WRs3-vBhjkpBA4ggSrKKC6oiSGlaJ0ao9_puM-QepepFpkqy1TvMpXImR8f9fN6Z7v_iX_2MsAXIOWnYWOjeg5zHPKXP239uYScDkpvok_q6YEDEgDWDTRSvAFVXofC</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>Guimarães, Adriana G</creator><creator>Gomes, Silvana V. 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S</au><au>Nogueira, Paulo C. L</au><au>Ferreira, Antônio G</au><au>Blank, Arie F</au><au>Santos, Alan D. C</au><au>Viana, Monalisa D</au><au>Silva, Geraldo H</au><au>Quintans Júnior, Lucindo J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phytochemical characterization and antinociceptive effect of Lippia gracilis Schauer</atitle><jtitle>Journal of natural medicines</jtitle><stitle>J Nat Med</stitle><addtitle>J Nat Med</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>66</volume><issue>3</issue><spage>428</spage><epage>434</epage><pages>428-434</pages><issn>1340-3443</issn><eissn>1861-0293</eissn><abstract>Lippia gracilis Schauer is an aromatic plant widely found in Northeastern Brazil. The leaf infusions or decoctions and alcoholic macerate are used for some inflammatory diseases and headache. This paper reports the isolation of naringenin by semi-preparative liquid chromatography from the methanolic extract of L. gracilis (ELg) and the evaluation of the analgesic and anti-inflammatory activities of this extract by measuring nociception through acetic acid, formalin, and hot-plate tests in carrageenan-induced inflammation in mice. Following oral administration, ELg (100, 200, and 400 mg/kg) significantly reduced the number of writhes in the writhing test and the time of paw licks in both phases of the formalin test when compared to the control group animals. Mice treated with ELg did not exhibit any behavioral alteration during the hot plate and rota-rod tests, suggesting non-participation of the supraspinal components in the modulation of pain by ELg and no motor abnormality. The oral administration of 400 mg/kg of ELg produced an anti-inflammatory effect on peritonitis induced by carrageenan. These effects can be associated with a decrease of inflammatory mediator synthesis by compounds of ELg, such as naringenin, which has anti-inflammatory action as already described.</abstract><cop>Japan</cop><pub>Springer-Verlag</pub><pmid>22146971</pmid><doi>10.1007/s11418-011-0601-3</doi><tpages>7</tpages></addata></record> |
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| subjects | acetic acid analgesic effect analgesics Analgesics - chemistry Analgesics - therapeutic use Animals anti-inflammatory activity Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - therapeutic use Biomedical and Life Sciences Biomedicine Brazil carrageenan Complementary & Alternative Medicine formalin headache inflammation leaves Lippia Lippia - chemistry liquid chromatography Male Medicinal Chemistry Mice naringenin nociception oral administration Original Paper Pain - drug therapy peritonitis Pharmacology/Toxicology Pharmacy Plant Extracts - chemistry Plant Extracts - therapeutic use Plant Sciences |
| title | Phytochemical characterization and antinociceptive effect of Lippia gracilis Schauer |
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