Region 8q24 is a susceptibility locus for nonsyndromic oral clefting in Brazil

BACKGROUND Nonsyndromic cleft lip with or without cleft palate is a relatively common craniofacial defect with multifactorial inheritance. The association of the rs987525 single nucleotide variant, located in a gene desert at 8q24.21 region, has been consistently replicated in European populations....

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Veröffentlicht in:	Birth defects research. A Clinical and molecular teratology 2012-06, Vol.94 (6), p.464-468
Hauptverfasser:	Brito, Luciano Abreu, Paranaiba, Lívia Máris Ribeiro, Bassi, Camila Fernandes Silva, Masotti, Cibele, Malcher, Carolina, Schlesinger, David, Rocha, Katia Maria, Cruz, Lucas Alvizi, Bárbara, Lígia Kobayashi, Alonso, Nivaldo, Franco, Diogo, Bagordakis, Elizabete, Martelli Jr, Hercílio, Meyer, Diogo, Coletta, Ricardo D., Passos-Bueno, Maria Rita
Format:	Artikel
Sprache:	eng
Schlagworte:	8q24 gene desert Brazil - epidemiology Case-Control Studies Chromosomes, Human, Pair 8 cleft lip Cleft Lip - ethnology Cleft Lip - genetics cleft palate Cleft Palate - ethnology Cleft Palate - genetics common disease-common variant Continental Population Groups Female Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study heritability Heterozygote Homozygote Humans Male mesenchymal stem cells MYC transcriptional levels Polymorphism, Single Nucleotide Proto-Oncogene Proteins c-myc - genetics rs1476165 rs2099897 rs987525 Transcription, Genetic
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