Dna2 Offers Support for Stalled Forks

Dna2 Offers Support for Stalled Forks

The ATR and ATM checkpoint kinases preserve the integrity of replicating chromosomes by preventing the reversal of stalled and terminal replication forks. Hu et al. now show that the ATR pathway targets the Dna2 nuclease to process stalled forks and counteract fork reversal.

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Bibliographische Detailangaben
Veröffentlicht in:Cell 2012-06, Vol.149 (6), p.1181-1183
Hauptverfasser: Lai, Mong Sing, Foiani, Marco
Format: Artikel
Sprache:eng
Schlagworte:
chromosomes
DNA
DNA replication
phosphotransferases (kinases)
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Beschreibung
Zusammenfassung:The ATR and ATM checkpoint kinases preserve the integrity of replicating chromosomes by preventing the reversal of stalled and terminal replication forks. Hu et al. now show that the ATR pathway targets the Dna2 nuclease to process stalled forks and counteract fork reversal.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2012.05.021