Breakthrough Pain in Patients Referred to Pain Clinics: The Italian Pain Network Retrospective Study
Introduction Despite breakthrough pain (BTP) being one of the most severe forms of pain, there are no definitive data on its prevalence. Methods The authors performed a retrospective survey of the prevalence of BTP in consecutive patients in four Italian pain clinics, subsequent to application of an...
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| Veröffentlicht in: | Advances in therapy 2012-05, Vol.29 (5), p.464-472 |
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| creator | Gatti, Antonio Mediati, Rocco D. Reale, Carlo Cuomo, Arturo Vellucci, Renato Russo, Gennaro Costantini, Amedeo Canneti, Alessandro Luzi, Marta Mammucari, Massimo Sabato, Alessandro Fabrizio |
| description | Introduction
Despite breakthrough pain (BTP) being one of the most severe forms of pain, there are no definitive data on its prevalence.
Methods
The authors performed a retrospective survey of the prevalence of BTP in consecutive patients in four Italian pain clinics, subsequent to application of an Italian law mandating detailed clinical records on pain characteristics, treatment, and results. Mean pain intensity was assessed with a numerical rating scale from 0 to 10.
Results
The authors analyzed records of 1,401 patients (58% women, 33.1% patients with cancer). Transient episodes of severe pain or BTP were referred by 790 patients (56.4%), including 58.2% of the men (342 of 588) and 55.1% of the women (448 of 813). Among the 464 patients with cancer, 70.3% reported daily exacerbation of pain. The mean BTP intensity was 8.31 ± 1.58 and 31.1% of patients reported experiencing three episodes per day.
Conclusion
Despite some limitations of the study, the authors show that transient episodes of severe pain or BTP are significantly present both in cancer and other diseases, and that many patients are not yet receiving appropriate opioid therapy. The authors need validated tools at international level for the diagnosis and treatment of BTP in patients with cancer and for transitory and patients with severe non-cancer pain. A survey at national level is needed to estimate the prevalence of BTP in different settings, to plan specific medical education. |
| doi_str_mv | 10.1007/s12325-012-0022-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1020048358</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1020048358</sourcerecordid><originalsourceid>FETCH-LOGICAL-c344t-b78b8864e912ea4581d53b10b48cf974ecf20b757c4508370371e503a4bb810c3</originalsourceid><addsrcrecordid>eNp9kMlOwzAURS0EgjJ8ABuUJRuDx9plBxVDJQQVg8TOcpwXGpomxXZA5etxFWCJZMuLe-7T80HokJITSog6DZRxJjGhDBPCGP7aQAOqhxKnyzbRgChBMeP6ZQfthvCWGKKk3kY7jA0ZE1oPUHHhwc7jzLfd6yyb2qrJ0pnaWEETQ_YAJXgPRRbbPhzXVVO5cJY9zSCbRFtXtumTO4ifrZ-nSvRtWIKL1Qdkj7ErVvtoq7R1gIOfdw89X10-jW_w7f31ZHx-ix0XIuJc6VzroYARZWCF1LSQPKckF9qVIyXAlYzkSionJNFcEa4oSMKtyHNNieN76Lifu_TtewchmkUVHNS1baDtgqFJABGaS51Q2qMuLRs8lGbpq4X1qwSZtVzTyzVJrlnLNV-pc_QzvssXUPw1fm0mgPVASFHzCt68tZ1v0pf_mfoN0CeEkg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1020048358</pqid></control><display><type>article</type><title>Breakthrough Pain in Patients Referred to Pain Clinics: The Italian Pain Network Retrospective Study</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Gatti, Antonio ; Mediati, Rocco D. ; Reale, Carlo ; Cuomo, Arturo ; Vellucci, Renato ; Russo, Gennaro ; Costantini, Amedeo ; Canneti, Alessandro ; Luzi, Marta ; Mammucari, Massimo ; Sabato, Alessandro Fabrizio</creator><creatorcontrib>Gatti, Antonio ; Mediati, Rocco D. ; Reale, Carlo ; Cuomo, Arturo ; Vellucci, Renato ; Russo, Gennaro ; Costantini, Amedeo ; Canneti, Alessandro ; Luzi, Marta ; Mammucari, Massimo ; Sabato, Alessandro Fabrizio</creatorcontrib><description>Introduction
Despite breakthrough pain (BTP) being one of the most severe forms of pain, there are no definitive data on its prevalence.
Methods
The authors performed a retrospective survey of the prevalence of BTP in consecutive patients in four Italian pain clinics, subsequent to application of an Italian law mandating detailed clinical records on pain characteristics, treatment, and results. Mean pain intensity was assessed with a numerical rating scale from 0 to 10.
Results
The authors analyzed records of 1,401 patients (58% women, 33.1% patients with cancer). Transient episodes of severe pain or BTP were referred by 790 patients (56.4%), including 58.2% of the men (342 of 588) and 55.1% of the women (448 of 813). Among the 464 patients with cancer, 70.3% reported daily exacerbation of pain. The mean BTP intensity was 8.31 ± 1.58 and 31.1% of patients reported experiencing three episodes per day.
Conclusion
Despite some limitations of the study, the authors show that transient episodes of severe pain or BTP are significantly present both in cancer and other diseases, and that many patients are not yet receiving appropriate opioid therapy. The authors need validated tools at international level for the diagnosis and treatment of BTP in patients with cancer and for transitory and patients with severe non-cancer pain. A survey at national level is needed to estimate the prevalence of BTP in different settings, to plan specific medical education.</description><identifier>ISSN: 0741-238X</identifier><identifier>EISSN: 1865-8652</identifier><identifier>DOI: 10.1007/s12325-012-0022-z</identifier><identifier>PMID: 22622488</identifier><language>eng</language><publisher>Heidelberg: Springer Healthcare Communications</publisher><subject>Analgesics, Opioid - administration & dosage ; Analgesics, Opioid - adverse effects ; Analgesics, Opioid - therapeutic use ; Breakthrough Pain - diagnosis ; Breakthrough Pain - drug therapy ; Breakthrough Pain - epidemiology ; Cardiology ; Drug Administration Routes ; Drug Administration Schedule ; Endocrinology ; Female ; Health technology assessment ; Humans ; Internal Medicine ; Italy - epidemiology ; Male ; Medicine ; Medicine & Public Health ; Neoplasms - complications ; Oncology ; Original Research ; Pain - etiology ; Pain Clinics - statistics & numerical data ; Pain Measurement ; Pharmacology/Toxicology ; Prevalence ; Retrospective Studies ; Rheumatology</subject><ispartof>Advances in therapy, 2012-05, Vol.29 (5), p.464-472</ispartof><rights>Springer Healthcare 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-b78b8864e912ea4581d53b10b48cf974ecf20b757c4508370371e503a4bb810c3</citedby><cites>FETCH-LOGICAL-c344t-b78b8864e912ea4581d53b10b48cf974ecf20b757c4508370371e503a4bb810c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12325-012-0022-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12325-012-0022-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22622488$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gatti, Antonio</creatorcontrib><creatorcontrib>Mediati, Rocco D.</creatorcontrib><creatorcontrib>Reale, Carlo</creatorcontrib><creatorcontrib>Cuomo, Arturo</creatorcontrib><creatorcontrib>Vellucci, Renato</creatorcontrib><creatorcontrib>Russo, Gennaro</creatorcontrib><creatorcontrib>Costantini, Amedeo</creatorcontrib><creatorcontrib>Canneti, Alessandro</creatorcontrib><creatorcontrib>Luzi, Marta</creatorcontrib><creatorcontrib>Mammucari, Massimo</creatorcontrib><creatorcontrib>Sabato, Alessandro Fabrizio</creatorcontrib><title>Breakthrough Pain in Patients Referred to Pain Clinics: The Italian Pain Network Retrospective Study</title><title>Advances in therapy</title><addtitle>Adv Therapy</addtitle><addtitle>Adv Ther</addtitle><description>Introduction
Despite breakthrough pain (BTP) being one of the most severe forms of pain, there are no definitive data on its prevalence.
Methods
The authors performed a retrospective survey of the prevalence of BTP in consecutive patients in four Italian pain clinics, subsequent to application of an Italian law mandating detailed clinical records on pain characteristics, treatment, and results. Mean pain intensity was assessed with a numerical rating scale from 0 to 10.
Results
The authors analyzed records of 1,401 patients (58% women, 33.1% patients with cancer). Transient episodes of severe pain or BTP were referred by 790 patients (56.4%), including 58.2% of the men (342 of 588) and 55.1% of the women (448 of 813). Among the 464 patients with cancer, 70.3% reported daily exacerbation of pain. The mean BTP intensity was 8.31 ± 1.58 and 31.1% of patients reported experiencing three episodes per day.
Conclusion
Despite some limitations of the study, the authors show that transient episodes of severe pain or BTP are significantly present both in cancer and other diseases, and that many patients are not yet receiving appropriate opioid therapy. The authors need validated tools at international level for the diagnosis and treatment of BTP in patients with cancer and for transitory and patients with severe non-cancer pain. A survey at national level is needed to estimate the prevalence of BTP in different settings, to plan specific medical education.</description><subject>Analgesics, Opioid - administration & dosage</subject><subject>Analgesics, Opioid - adverse effects</subject><subject>Analgesics, Opioid - therapeutic use</subject><subject>Breakthrough Pain - diagnosis</subject><subject>Breakthrough Pain - drug therapy</subject><subject>Breakthrough Pain - epidemiology</subject><subject>Cardiology</subject><subject>Drug Administration Routes</subject><subject>Drug Administration Schedule</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Health technology assessment</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Italy - epidemiology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neoplasms - complications</subject><subject>Oncology</subject><subject>Original Research</subject><subject>Pain - etiology</subject><subject>Pain Clinics - statistics & numerical data</subject><subject>Pain Measurement</subject><subject>Pharmacology/Toxicology</subject><subject>Prevalence</subject><subject>Retrospective Studies</subject><subject>Rheumatology</subject><issn>0741-238X</issn><issn>1865-8652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMlOwzAURS0EgjJ8ABuUJRuDx9plBxVDJQQVg8TOcpwXGpomxXZA5etxFWCJZMuLe-7T80HokJITSog6DZRxJjGhDBPCGP7aQAOqhxKnyzbRgChBMeP6ZQfthvCWGKKk3kY7jA0ZE1oPUHHhwc7jzLfd6yyb2qrJ0pnaWEETQ_YAJXgPRRbbPhzXVVO5cJY9zSCbRFtXtumTO4ifrZ-nSvRtWIKL1Qdkj7ErVvtoq7R1gIOfdw89X10-jW_w7f31ZHx-ix0XIuJc6VzroYARZWCF1LSQPKckF9qVIyXAlYzkSionJNFcEa4oSMKtyHNNieN76Lifu_TtewchmkUVHNS1baDtgqFJABGaS51Q2qMuLRs8lGbpq4X1qwSZtVzTyzVJrlnLNV-pc_QzvssXUPw1fm0mgPVASFHzCt68tZ1v0pf_mfoN0CeEkg</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Gatti, Antonio</creator><creator>Mediati, Rocco D.</creator><creator>Reale, Carlo</creator><creator>Cuomo, Arturo</creator><creator>Vellucci, Renato</creator><creator>Russo, Gennaro</creator><creator>Costantini, Amedeo</creator><creator>Canneti, Alessandro</creator><creator>Luzi, Marta</creator><creator>Mammucari, Massimo</creator><creator>Sabato, Alessandro Fabrizio</creator><general>Springer Healthcare Communications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120501</creationdate><title>Breakthrough Pain in Patients Referred to Pain Clinics: The Italian Pain Network Retrospective Study</title><author>Gatti, Antonio ; Mediati, Rocco D. ; Reale, Carlo ; Cuomo, Arturo ; Vellucci, Renato ; Russo, Gennaro ; Costantini, Amedeo ; Canneti, Alessandro ; Luzi, Marta ; Mammucari, Massimo ; Sabato, Alessandro Fabrizio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-b78b8864e912ea4581d53b10b48cf974ecf20b757c4508370371e503a4bb810c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Analgesics, Opioid - administration & dosage</topic><topic>Analgesics, Opioid - adverse effects</topic><topic>Analgesics, Opioid - therapeutic use</topic><topic>Breakthrough Pain - diagnosis</topic><topic>Breakthrough Pain - drug therapy</topic><topic>Breakthrough Pain - epidemiology</topic><topic>Cardiology</topic><topic>Drug Administration Routes</topic><topic>Drug Administration Schedule</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Health technology assessment</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Italy - epidemiology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neoplasms - complications</topic><topic>Oncology</topic><topic>Original Research</topic><topic>Pain - etiology</topic><topic>Pain Clinics - statistics & numerical data</topic><topic>Pain Measurement</topic><topic>Pharmacology/Toxicology</topic><topic>Prevalence</topic><topic>Retrospective Studies</topic><topic>Rheumatology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gatti, Antonio</creatorcontrib><creatorcontrib>Mediati, Rocco D.</creatorcontrib><creatorcontrib>Reale, Carlo</creatorcontrib><creatorcontrib>Cuomo, Arturo</creatorcontrib><creatorcontrib>Vellucci, Renato</creatorcontrib><creatorcontrib>Russo, Gennaro</creatorcontrib><creatorcontrib>Costantini, Amedeo</creatorcontrib><creatorcontrib>Canneti, Alessandro</creatorcontrib><creatorcontrib>Luzi, Marta</creatorcontrib><creatorcontrib>Mammucari, Massimo</creatorcontrib><creatorcontrib>Sabato, Alessandro Fabrizio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Advances in therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gatti, Antonio</au><au>Mediati, Rocco D.</au><au>Reale, Carlo</au><au>Cuomo, Arturo</au><au>Vellucci, Renato</au><au>Russo, Gennaro</au><au>Costantini, Amedeo</au><au>Canneti, Alessandro</au><au>Luzi, Marta</au><au>Mammucari, Massimo</au><au>Sabato, Alessandro Fabrizio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Breakthrough Pain in Patients Referred to Pain Clinics: The Italian Pain Network Retrospective Study</atitle><jtitle>Advances in therapy</jtitle><stitle>Adv Therapy</stitle><addtitle>Adv Ther</addtitle><date>2012-05-01</date><risdate>2012</risdate><volume>29</volume><issue>5</issue><spage>464</spage><epage>472</epage><pages>464-472</pages><issn>0741-238X</issn><eissn>1865-8652</eissn><abstract>Introduction
Despite breakthrough pain (BTP) being one of the most severe forms of pain, there are no definitive data on its prevalence.
Methods
The authors performed a retrospective survey of the prevalence of BTP in consecutive patients in four Italian pain clinics, subsequent to application of an Italian law mandating detailed clinical records on pain characteristics, treatment, and results. Mean pain intensity was assessed with a numerical rating scale from 0 to 10.
Results
The authors analyzed records of 1,401 patients (58% women, 33.1% patients with cancer). Transient episodes of severe pain or BTP were referred by 790 patients (56.4%), including 58.2% of the men (342 of 588) and 55.1% of the women (448 of 813). Among the 464 patients with cancer, 70.3% reported daily exacerbation of pain. The mean BTP intensity was 8.31 ± 1.58 and 31.1% of patients reported experiencing three episodes per day.
Conclusion
Despite some limitations of the study, the authors show that transient episodes of severe pain or BTP are significantly present both in cancer and other diseases, and that many patients are not yet receiving appropriate opioid therapy. The authors need validated tools at international level for the diagnosis and treatment of BTP in patients with cancer and for transitory and patients with severe non-cancer pain. A survey at national level is needed to estimate the prevalence of BTP in different settings, to plan specific medical education.</abstract><cop>Heidelberg</cop><pub>Springer Healthcare Communications</pub><pmid>22622488</pmid><doi>10.1007/s12325-012-0022-z</doi><tpages>9</tpages></addata></record> |
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| subjects | Analgesics, Opioid - administration & dosage Analgesics, Opioid - adverse effects Analgesics, Opioid - therapeutic use Breakthrough Pain - diagnosis Breakthrough Pain - drug therapy Breakthrough Pain - epidemiology Cardiology Drug Administration Routes Drug Administration Schedule Endocrinology Female Health technology assessment Humans Internal Medicine Italy - epidemiology Male Medicine Medicine & Public Health Neoplasms - complications Oncology Original Research Pain - etiology Pain Clinics - statistics & numerical data Pain Measurement Pharmacology/Toxicology Prevalence Retrospective Studies Rheumatology |
| title | Breakthrough Pain in Patients Referred to Pain Clinics: The Italian Pain Network Retrospective Study |
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