Synthesis, stereochemistry and cytotoxic activity of novel steroidal 16-spiro-1,3,2-dioxaphosphorinanes

► Phosphorylation reactions of 16,16-bis(hydroxymethyl)androst-4-ene-3,17-dione with different P(V) reagents were carried out. ► Novel steroidal 16-spiro dioxaphosphorinanes were synthetized. ► The stereostructures of the hetero ring were investigated by NMR measurements. ► Antiproliferative activit...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of molecular structure 2012-04, Vol.1013, p.39-44
Hauptverfasser:	Wölfling, János, Kovács-Pénzes, Piroska, Zupkó, István, Schneider, Gyula, Frank, Éva
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiproliferative effect Antiproliferatives Atomic properties Chairs cytotoxicity Dioxaphosphorinanes Human human cell lines Molecular structure nuclear magnetic resonance spectroscopy phosphorylation Phosphorylations Rigidity Spiro compounds Stereochemistry Stereostructure Steroids Synthesis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!