Using a bifunctional polymer for the functionalization of Fe3O4 nanoparticles
A bifunctional maleimido-tetra(ethylene glycol)-poly(glycerol monoacrylate) (MAL-TEG-PGA) polymer was synthesized and used as a linker to couple functional biomolecules to iron oxide nanoparticles. The cell-penetrating peptide Tat was chosen as a model ligand and successfully conjugated to the surfa...
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| Veröffentlicht in: | Reactive & functional polymers 2012-03, Vol.72 (3), p.198-205 |
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| container_issue | 3 |
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| container_title | Reactive & functional polymers |
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| creator | Zhang, Quan Luan, Liang Feng, Siliang Yan, Husheng Liu, Keliang |
| description | A bifunctional maleimido-tetra(ethylene glycol)-poly(glycerol monoacrylate) (MAL-TEG-PGA) polymer was synthesized and used as a linker to couple functional biomolecules to iron oxide nanoparticles. The cell-penetrating peptide Tat was chosen as a model ligand and successfully conjugated to the surface of Fe3O4 nanoparticles using MAL-TEG-PGA. The Tat-conjugated Fe3O4 nanoparticles can be prepared simply by applying the linker to the iron oxide nanoparticles and then coupling the Tat peptide to the maleimide terminus or by coating the nanoparticles with a pre-coupled linker. Cell-uptake studies demonstrated that the Tat peptide was an efficient functional biomolecule to translocate iron oxide nanoparticles into the cell nucleus. Tat-conjugated nanoparticles thus prepared may be useful for drug or gene delivery. |
| doi_str_mv | 10.1016/j.reactfunctpolym.2012.01.003 |
| format | Article |
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The cell-penetrating peptide Tat was chosen as a model ligand and successfully conjugated to the surface of Fe3O4 nanoparticles using MAL-TEG-PGA. The Tat-conjugated Fe3O4 nanoparticles can be prepared simply by applying the linker to the iron oxide nanoparticles and then coupling the Tat peptide to the maleimide terminus or by coating the nanoparticles with a pre-coupled linker. Cell-uptake studies demonstrated that the Tat peptide was an efficient functional biomolecule to translocate iron oxide nanoparticles into the cell nucleus. Tat-conjugated nanoparticles thus prepared may be useful for drug or gene delivery.</description><identifier>ISSN: 1381-5148</identifier><identifier>DOI: 10.1016/j.reactfunctpolym.2012.01.003</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Applied sciences ; Bifunctional polymer ; Biological and medical sciences ; Biomolecules ; Exact sciences and technology ; Fe3O4 ; Functionalization of nanoparticles ; General pharmacology ; Genes ; Iron oxides ; Joining ; Ligands ; Medical sciences ; Nanoparticles ; Nuclear delivery ; Nuclei ; Organic polymers ; Peptides ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Physicochemistry of polymers ; Polymers with particular structures ; Preparation, kinetics, thermodynamics, mechanism and catalysts ; Tat peptide</subject><ispartof>Reactive & functional polymers, 2012-03, Vol.72 (3), p.198-205</ispartof><rights>2012 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c326t-19cacef8b10348eef5e0b1efbf70e3fe048797754eaae5651792fa23d76151bf3</citedby><cites>FETCH-LOGICAL-c326t-19cacef8b10348eef5e0b1efbf70e3fe048797754eaae5651792fa23d76151bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.reactfunctpolym.2012.01.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25651430$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Quan</creatorcontrib><creatorcontrib>Luan, Liang</creatorcontrib><creatorcontrib>Feng, Siliang</creatorcontrib><creatorcontrib>Yan, Husheng</creatorcontrib><creatorcontrib>Liu, Keliang</creatorcontrib><title>Using a bifunctional polymer for the functionalization of Fe3O4 nanoparticles</title><title>Reactive & functional polymers</title><description>A bifunctional maleimido-tetra(ethylene glycol)-poly(glycerol monoacrylate) (MAL-TEG-PGA) polymer was synthesized and used as a linker to couple functional biomolecules to iron oxide nanoparticles. The cell-penetrating peptide Tat was chosen as a model ligand and successfully conjugated to the surface of Fe3O4 nanoparticles using MAL-TEG-PGA. The Tat-conjugated Fe3O4 nanoparticles can be prepared simply by applying the linker to the iron oxide nanoparticles and then coupling the Tat peptide to the maleimide terminus or by coating the nanoparticles with a pre-coupled linker. Cell-uptake studies demonstrated that the Tat peptide was an efficient functional biomolecule to translocate iron oxide nanoparticles into the cell nucleus. Tat-conjugated nanoparticles thus prepared may be useful for drug or gene delivery.</description><subject>Applied sciences</subject><subject>Bifunctional polymer</subject><subject>Biological and medical sciences</subject><subject>Biomolecules</subject><subject>Exact sciences and technology</subject><subject>Fe3O4</subject><subject>Functionalization of nanoparticles</subject><subject>General pharmacology</subject><subject>Genes</subject><subject>Iron oxides</subject><subject>Joining</subject><subject>Ligands</subject><subject>Medical sciences</subject><subject>Nanoparticles</subject><subject>Nuclear delivery</subject><subject>Nuclei</subject><subject>Organic polymers</subject><subject>Peptides</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Physicochemistry of polymers</subject><subject>Polymers with particular structures</subject><subject>Preparation, kinetics, thermodynamics, mechanism and catalysts</subject><subject>Tat peptide</subject><issn>1381-5148</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqNkDFPwzAQhT2ARCn8By-VWBp8cWInAwOqoCAVdaGz5bhncJXGwU6Ryq8naSuQmJjupPvuvbtHyARYAgzE7SYJqE1nd43pWl_vt0nKIE0YJIzxMzICXsA0h6y4IJcxbhgDCUKMyMsquuaNalq5w67zja7pQQEDtT7Q7h3p78h96aGh3tJH5MuMNrrxrQ6dMzXGK3JudR3x-lTHZPX48Dp7mi6W8-fZ_WJqeCq6KZRGG7RFBYxnBaLNkVWAtrKSIbfIskKWUuYZao25yEGWqdUpX0sBOVSWj8nNUbcN_mOHsVNbFw3WtW7Q76LqIylFJmTBevTuiJrgYwxoVRvcVod9Dw2cUBv1Jzo1RKcYqD66fn9ystLR6NoG3RgXf0TS4byMDz7zI4f9358Og4rGYWNw7QKaTq29-6fjN8FqkbA</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Zhang, Quan</creator><creator>Luan, Liang</creator><creator>Feng, Siliang</creator><creator>Yan, Husheng</creator><creator>Liu, Keliang</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope></search><sort><creationdate>20120301</creationdate><title>Using a bifunctional polymer for the functionalization of Fe3O4 nanoparticles</title><author>Zhang, Quan ; Luan, Liang ; Feng, Siliang ; Yan, Husheng ; Liu, Keliang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-19cacef8b10348eef5e0b1efbf70e3fe048797754eaae5651792fa23d76151bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Applied sciences</topic><topic>Bifunctional polymer</topic><topic>Biological and medical sciences</topic><topic>Biomolecules</topic><topic>Exact sciences and technology</topic><topic>Fe3O4</topic><topic>Functionalization of nanoparticles</topic><topic>General pharmacology</topic><topic>Genes</topic><topic>Iron oxides</topic><topic>Joining</topic><topic>Ligands</topic><topic>Medical sciences</topic><topic>Nanoparticles</topic><topic>Nuclear delivery</topic><topic>Nuclei</topic><topic>Organic polymers</topic><topic>Peptides</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Physicochemistry of polymers</topic><topic>Polymers with particular structures</topic><topic>Preparation, kinetics, thermodynamics, mechanism and catalysts</topic><topic>Tat peptide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Quan</creatorcontrib><creatorcontrib>Luan, Liang</creatorcontrib><creatorcontrib>Feng, Siliang</creatorcontrib><creatorcontrib>Yan, Husheng</creatorcontrib><creatorcontrib>Liu, Keliang</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Reactive & functional polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Quan</au><au>Luan, Liang</au><au>Feng, Siliang</au><au>Yan, Husheng</au><au>Liu, Keliang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Using a bifunctional polymer for the functionalization of Fe3O4 nanoparticles</atitle><jtitle>Reactive & functional polymers</jtitle><date>2012-03-01</date><risdate>2012</risdate><volume>72</volume><issue>3</issue><spage>198</spage><epage>205</epage><pages>198-205</pages><issn>1381-5148</issn><abstract>A bifunctional maleimido-tetra(ethylene glycol)-poly(glycerol monoacrylate) (MAL-TEG-PGA) polymer was synthesized and used as a linker to couple functional biomolecules to iron oxide nanoparticles. The cell-penetrating peptide Tat was chosen as a model ligand and successfully conjugated to the surface of Fe3O4 nanoparticles using MAL-TEG-PGA. The Tat-conjugated Fe3O4 nanoparticles can be prepared simply by applying the linker to the iron oxide nanoparticles and then coupling the Tat peptide to the maleimide terminus or by coating the nanoparticles with a pre-coupled linker. Cell-uptake studies demonstrated that the Tat peptide was an efficient functional biomolecule to translocate iron oxide nanoparticles into the cell nucleus. Tat-conjugated nanoparticles thus prepared may be useful for drug or gene delivery.</abstract><cop>Kidlington</cop><pub>Elsevier B.V</pub><doi>10.1016/j.reactfunctpolym.2012.01.003</doi><tpages>8</tpages></addata></record> |
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| ispartof | Reactive & functional polymers, 2012-03, Vol.72 (3), p.198-205 |
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| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Applied sciences Bifunctional polymer Biological and medical sciences Biomolecules Exact sciences and technology Fe3O4 Functionalization of nanoparticles General pharmacology Genes Iron oxides Joining Ligands Medical sciences Nanoparticles Nuclear delivery Nuclei Organic polymers Peptides Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers Polymers with particular structures Preparation, kinetics, thermodynamics, mechanism and catalysts Tat peptide |
| title | Using a bifunctional polymer for the functionalization of Fe3O4 nanoparticles |
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