Polyamine flux analysis by determination of heavy isotope incorporation from super(13)C, super(15)N-enriched amino acids into polyamines by LC-MS/MS

The study of polyamine flux, i.e. the circulating flow of polyamines through the interconnected biosynthetic and catabolic pathways, is of considerable interest because of the established links between the polyamine metabolism and many diseases, such as cancer and diabetes. To study polyamine flux i...

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Veröffentlicht in:Amino acids 2012-02, Vol.42 (2-3), p.451-460
Hauptverfasser: Cerrada-Gimenez, Marc, Haekkinen, Merja R, Vepsaelaeinen, Jouko, Auriola, Seppo, Alhonen, Leena, Keinaenen, Tuomo A
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Sprache:eng
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