Controlled release of ketoprofen from electrospun porous polylactic acid (PLA) nanofibers
Electrospun fibers can be promising drug carriers for future biomedical applications. In this work, electrospun PLA fibers were developed as a new system for the delivery of ketoprofen which is a non-steroidal anti-inflammatory drug. For effective control of drug release, porous PLA fiber was prepar...
Gespeichert in:
| Veröffentlicht in: | Journal of polymer research 2011-11, Vol.18 (6), p.1287-1291 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1291 |
|---|---|
| container_issue | 6 |
| container_start_page | 1287 |
| container_title | Journal of polymer research |
| container_volume | 18 |
| creator | Park, Ju-Young Lee, In-Hwa |
| description | Electrospun fibers can be promising drug carriers for future biomedical applications. In this work, electrospun PLA fibers were developed as a new system for the delivery of ketoprofen which is a non-steroidal anti-inflammatory drug. For effective control of drug release, porous PLA fiber was prepared by phase separation during electrospinning. The release of various contents of ketoprofen from the electrospun PLA fiber was investigated at body temperature (37 °C) and at room temperature (20 °C). The release rates of the ketoprofen drug from the PLA/ketoprofen fibers showed a relatively higher release rate at 37 °C than at 20 °C. As the ketoprofen content increased, the release effect (cumulative drug released) increased. Thermal characteristic of PLA/ketoprofen fiber was also analyzed. |
| doi_str_mv | 10.1007/s10965-010-9531-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1019627655</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1019627655</sourcerecordid><originalsourceid>FETCH-LOGICAL-c348t-8d03a8db925d29ded45f1923bc18495c29aaa4f5d8fc808704c82d663cdb4f733</originalsourceid><addsrcrecordid>eNp1kEtLxDAUhYMoOI7-AHfB1bio3qRNmyyHwRcM6EIXrkKah3TsJGPSLubfm6GCILi6F-53DucehC4J3BCA5jYREDUrgEAhWEkKOEIzwhpacFGy47wDpYVoajhFZyltABhraj5D76vghxj63hocbW9Vsjg4_GmHsIvBWY9dDFucLzpjaTd6vAsxjCmPft8rPXQaK90ZvHhZL6-xVz64rrUxnaMTp_pkL37mHL3d372uHov188PTarkudFnxoeAGSsVNKygzVBhrKuaIoGWrCa8E01QopSrHDHeaA2-g0pyaui61aSvXlOUcLSbfnPdrtGmQ2y5p2_fK25xTEiCipk3NWEav_qCbMEaf00kBjFIh4OBHJkjnf1O0Tu5it1Vxn53koWs5dS1z1_LQtYSsoZMmZdZ_2Phr_L_oG_I0gaM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>905229903</pqid></control><display><type>article</type><title>Controlled release of ketoprofen from electrospun porous polylactic acid (PLA) nanofibers</title><source>SpringerLink Journals - AutoHoldings</source><creator>Park, Ju-Young ; Lee, In-Hwa</creator><creatorcontrib>Park, Ju-Young ; Lee, In-Hwa</creatorcontrib><description>Electrospun fibers can be promising drug carriers for future biomedical applications. In this work, electrospun PLA fibers were developed as a new system for the delivery of ketoprofen which is a non-steroidal anti-inflammatory drug. For effective control of drug release, porous PLA fiber was prepared by phase separation during electrospinning. The release of various contents of ketoprofen from the electrospun PLA fiber was investigated at body temperature (37 °C) and at room temperature (20 °C). The release rates of the ketoprofen drug from the PLA/ketoprofen fibers showed a relatively higher release rate at 37 °C than at 20 °C. As the ketoprofen content increased, the release effect (cumulative drug released) increased. Thermal characteristic of PLA/ketoprofen fiber was also analyzed.</description><identifier>ISSN: 1022-9760</identifier><identifier>EISSN: 1572-8935</identifier><identifier>DOI: 10.1007/s10965-010-9531-0</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Carriers ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Controlled release ; Drugs ; Electrospinning ; Fibers ; Industrial Chemistry/Chemical Engineering ; Ketoprofen ; Nanofibers ; Original Paper ; Phase separation ; Polymer Sciences</subject><ispartof>Journal of polymer research, 2011-11, Vol.18 (6), p.1287-1291</ispartof><rights>Springer Science+Business Media B.V. 2010</rights><rights>Springer Science+Business Media B.V. 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c348t-8d03a8db925d29ded45f1923bc18495c29aaa4f5d8fc808704c82d663cdb4f733</citedby><cites>FETCH-LOGICAL-c348t-8d03a8db925d29ded45f1923bc18495c29aaa4f5d8fc808704c82d663cdb4f733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10965-010-9531-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10965-010-9531-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Park, Ju-Young</creatorcontrib><creatorcontrib>Lee, In-Hwa</creatorcontrib><title>Controlled release of ketoprofen from electrospun porous polylactic acid (PLA) nanofibers</title><title>Journal of polymer research</title><addtitle>J Polym Res</addtitle><description>Electrospun fibers can be promising drug carriers for future biomedical applications. In this work, electrospun PLA fibers were developed as a new system for the delivery of ketoprofen which is a non-steroidal anti-inflammatory drug. For effective control of drug release, porous PLA fiber was prepared by phase separation during electrospinning. The release of various contents of ketoprofen from the electrospun PLA fiber was investigated at body temperature (37 °C) and at room temperature (20 °C). The release rates of the ketoprofen drug from the PLA/ketoprofen fibers showed a relatively higher release rate at 37 °C than at 20 °C. As the ketoprofen content increased, the release effect (cumulative drug released) increased. Thermal characteristic of PLA/ketoprofen fiber was also analyzed.</description><subject>Carriers</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Controlled release</subject><subject>Drugs</subject><subject>Electrospinning</subject><subject>Fibers</subject><subject>Industrial Chemistry/Chemical Engineering</subject><subject>Ketoprofen</subject><subject>Nanofibers</subject><subject>Original Paper</subject><subject>Phase separation</subject><subject>Polymer Sciences</subject><issn>1022-9760</issn><issn>1572-8935</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1kEtLxDAUhYMoOI7-AHfB1bio3qRNmyyHwRcM6EIXrkKah3TsJGPSLubfm6GCILi6F-53DucehC4J3BCA5jYREDUrgEAhWEkKOEIzwhpacFGy47wDpYVoajhFZyltABhraj5D76vghxj63hocbW9Vsjg4_GmHsIvBWY9dDFucLzpjaTd6vAsxjCmPft8rPXQaK90ZvHhZL6-xVz64rrUxnaMTp_pkL37mHL3d372uHov188PTarkudFnxoeAGSsVNKygzVBhrKuaIoGWrCa8E01QopSrHDHeaA2-g0pyaui61aSvXlOUcLSbfnPdrtGmQ2y5p2_fK25xTEiCipk3NWEav_qCbMEaf00kBjFIh4OBHJkjnf1O0Tu5it1Vxn53koWs5dS1z1_LQtYSsoZMmZdZ_2Phr_L_oG_I0gaM</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>Park, Ju-Young</creator><creator>Lee, In-Hwa</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20111101</creationdate><title>Controlled release of ketoprofen from electrospun porous polylactic acid (PLA) nanofibers</title><author>Park, Ju-Young ; Lee, In-Hwa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-8d03a8db925d29ded45f1923bc18495c29aaa4f5d8fc808704c82d663cdb4f733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Carriers</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Controlled release</topic><topic>Drugs</topic><topic>Electrospinning</topic><topic>Fibers</topic><topic>Industrial Chemistry/Chemical Engineering</topic><topic>Ketoprofen</topic><topic>Nanofibers</topic><topic>Original Paper</topic><topic>Phase separation</topic><topic>Polymer Sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Ju-Young</creatorcontrib><creatorcontrib>Lee, In-Hwa</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Journal of polymer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Ju-Young</au><au>Lee, In-Hwa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Controlled release of ketoprofen from electrospun porous polylactic acid (PLA) nanofibers</atitle><jtitle>Journal of polymer research</jtitle><stitle>J Polym Res</stitle><date>2011-11-01</date><risdate>2011</risdate><volume>18</volume><issue>6</issue><spage>1287</spage><epage>1291</epage><pages>1287-1291</pages><issn>1022-9760</issn><eissn>1572-8935</eissn><abstract>Electrospun fibers can be promising drug carriers for future biomedical applications. In this work, electrospun PLA fibers were developed as a new system for the delivery of ketoprofen which is a non-steroidal anti-inflammatory drug. For effective control of drug release, porous PLA fiber was prepared by phase separation during electrospinning. The release of various contents of ketoprofen from the electrospun PLA fiber was investigated at body temperature (37 °C) and at room temperature (20 °C). The release rates of the ketoprofen drug from the PLA/ketoprofen fibers showed a relatively higher release rate at 37 °C than at 20 °C. As the ketoprofen content increased, the release effect (cumulative drug released) increased. Thermal characteristic of PLA/ketoprofen fiber was also analyzed.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><doi>10.1007/s10965-010-9531-0</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1022-9760 |
| ispartof | Journal of polymer research, 2011-11, Vol.18 (6), p.1287-1291 |
| issn | 1022-9760 1572-8935 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1019627655 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Carriers Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Controlled release Drugs Electrospinning Fibers Industrial Chemistry/Chemical Engineering Ketoprofen Nanofibers Original Paper Phase separation Polymer Sciences |
| title | Controlled release of ketoprofen from electrospun porous polylactic acid (PLA) nanofibers |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T17%3A08%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Controlled%20release%20of%20ketoprofen%20from%20electrospun%20porous%20polylactic%20acid%20(PLA)%20nanofibers&rft.jtitle=Journal%20of%20polymer%20research&rft.au=Park,%20Ju-Young&rft.date=2011-11-01&rft.volume=18&rft.issue=6&rft.spage=1287&rft.epage=1291&rft.pages=1287-1291&rft.issn=1022-9760&rft.eissn=1572-8935&rft_id=info:doi/10.1007/s10965-010-9531-0&rft_dat=%3Cproquest_cross%3E1019627655%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=905229903&rft_id=info:pmid/&rfr_iscdi=true |