CD23+ CD21(high) CD1d(high) B cells in inflamed lymph nodes are a locally differentiated population with increased antigen capture and activation potential

CD23(+)CD21(high)CD1d(high) B cells in inflamed nodes (Bin cells) accumulate in the lymph nodes (LNs) draining inflamed joints of the TNF-α-transgenic mouse model of rheumatoid arthritis and are primarily involved in the significant histological and functional LN alterations that accompany disease e...

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Veröffentlicht in:	The Journal of immunology (1950) 2012-06, Vol.188 (12), p.5944-5953
Hauptverfasser:	Moshkani, Safiehkhatoon, Kuzin, Igor I, Adewale, Funmilola, Jansson, Johan, Sanz, Iñaki, Schwarz, Edward M, Bottaro, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Antigen Presentation - immunology Antigens, CD1d - immunology Antigens, CD1d - metabolism Arthritis, Experimental - immunology Arthritis, Rheumatoid - immunology B-Lymphocyte Subsets - cytology B-Lymphocyte Subsets - immunology B-Lymphocyte Subsets - metabolism B-Lymphocytes - cytology B-Lymphocytes - immunology B-Lymphocytes - metabolism Cell Differentiation - immunology Disease Models, Animal Enzyme-Linked Immunosorbent Assay Flow Cytometry Inflammation - immunology Inflammation - metabolism Lymph Nodes - cytology Lymph Nodes - immunology Lymphocyte Activation - immunology Mice Mice, Inbred C57BL Mice, Transgenic Receptors, Complement 3d - immunology Receptors, Complement 3d - metabolism Receptors, IgE - immunology Receptors, IgE - metabolism
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