Fungal infection presenting as giant cell tubulointerstitial nephritis in kidney allograft
Giant cell tubulointerstitial nephritis in the kidney allograft caused by infection is rare, and donor‐transmitted infection in transplanted kidneys is also rare. In this case report, we describe an unusual histological manifestation of Candida albicans in the graft biopsy of a 53‐year‐old male kidn...
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| Veröffentlicht in: | Transplant infectious disease 2012-06, Vol.14 (3), p.288-291 |
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| container_title | Transplant infectious disease |
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| creator | Bagnasco, S.M. Subramanian, A.K. Desai, N.M. |
| description | Giant cell tubulointerstitial nephritis in the kidney allograft caused by infection is rare, and donor‐transmitted infection in transplanted kidneys is also rare. In this case report, we describe an unusual histological manifestation of Candida albicans in the graft biopsy of a 53‐year‐old male kidney transplant recipient with decreased renal function 12 days post transplant. Several giant cells were present in the tubulointerstitial inflammation, as well as yeasts, with no evidence of rejection, and the histological diagnosis was confirmed by urine culture. Donor urine culture was positive for C. albicans, suggestive of a possible donor‐transmitted infection. Prompt antifungal treatment eradicated the infection, and averted systemic spread. To our knowledge, there are no previous reports of Candida infection with giant cell tubulointerstitial nephritis in human renal allograft. |
| doi_str_mv | 10.1111/j.1399-3062.2011.00676.x |
| format | Article |
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In this case report, we describe an unusual histological manifestation of Candida albicans in the graft biopsy of a 53‐year‐old male kidney transplant recipient with decreased renal function 12 days post transplant. Several giant cells were present in the tubulointerstitial inflammation, as well as yeasts, with no evidence of rejection, and the histological diagnosis was confirmed by urine culture. Donor urine culture was positive for C. albicans, suggestive of a possible donor‐transmitted infection. Prompt antifungal treatment eradicated the infection, and averted systemic spread. 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In this case report, we describe an unusual histological manifestation of Candida albicans in the graft biopsy of a 53‐year‐old male kidney transplant recipient with decreased renal function 12 days post transplant. Several giant cells were present in the tubulointerstitial inflammation, as well as yeasts, with no evidence of rejection, and the histological diagnosis was confirmed by urine culture. Donor urine culture was positive for C. albicans, suggestive of a possible donor‐transmitted infection. Prompt antifungal treatment eradicated the infection, and averted systemic spread. To our knowledge, there are no previous reports of Candida infection with giant cell tubulointerstitial nephritis in human renal allograft.</description><subject>Antifungal Agents - therapeutic use</subject><subject>biopsy</subject><subject>Candida</subject><subject>Candida albicans - isolation & purification</subject><subject>Candidiasis - drug therapy</subject><subject>Candidiasis - microbiology</subject><subject>donor-transmitted</subject><subject>giant cell</subject><subject>Humans</subject><subject>kidney transplant</subject><subject>Kidney Transplantation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nephritis, Interstitial - drug therapy</subject><subject>Nephritis, Interstitial - microbiology</subject><subject>Tissue Donors</subject><subject>Transplantation, Homologous</subject><subject>Treatment Outcome</subject><subject>Urine - microbiology</subject><issn>1398-2273</issn><issn>1399-3062</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1O3DAUha2KqlDgFZCXbJL6L3YssYHhp0ijVqqokNhYTmIPHjLOYDti5u1xGDrreuMj-XzXVx8AEKMS5_NjWWIqZUERJyVBGJcIccHLzRdwtH84-Mh1QYigh-B7jEuEsJBMfgOHhCBJGSZH4Ol29AvdQ-etaZMbPFwHE41Pzi-gjnDhtE-wNX0P09iM_eB8MiEml1ymvFk_hxxj5uGL67zZQt33wyJom07AV6v7aE4_72Pw9_bmYfazmP--u59dzouWIc4LRjnuOlohxriQrSWCycpoJmpTo66rBLIW2aq20-41YY1tsJYYVY2sOiMZPQbnu7nrMLyOJia1cnHaWHszjFFhhCXHNSZ1rta7ahuGGIOxah3cSodtLqnJrFqqSaCaBKrJrPowqzYZPfv8ZWxWptuD_1TmwsWu8OZ6s_3vwerh_jqHjBc73MVkNntchxfFBRWVevx1p-jjfHb9p3pSV_Qd1iSWxg</recordid><startdate>201206</startdate><enddate>201206</enddate><creator>Bagnasco, S.M.</creator><creator>Subramanian, A.K.</creator><creator>Desai, N.M.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201206</creationdate><title>Fungal infection presenting as giant cell tubulointerstitial nephritis in kidney allograft</title><author>Bagnasco, S.M. ; Subramanian, A.K. ; Desai, N.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4066-4361dd35044679cf27495ea478e80dd570ff0f58f7949824bfb1a9105b95de943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Antifungal Agents - therapeutic use</topic><topic>biopsy</topic><topic>Candida</topic><topic>Candida albicans - isolation & purification</topic><topic>Candidiasis - drug therapy</topic><topic>Candidiasis - microbiology</topic><topic>donor-transmitted</topic><topic>giant cell</topic><topic>Humans</topic><topic>kidney transplant</topic><topic>Kidney Transplantation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nephritis, Interstitial - drug therapy</topic><topic>Nephritis, Interstitial - microbiology</topic><topic>Tissue Donors</topic><topic>Transplantation, Homologous</topic><topic>Treatment Outcome</topic><topic>Urine - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bagnasco, S.M.</creatorcontrib><creatorcontrib>Subramanian, A.K.</creatorcontrib><creatorcontrib>Desai, N.M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplant infectious disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bagnasco, S.M.</au><au>Subramanian, A.K.</au><au>Desai, N.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fungal infection presenting as giant cell tubulointerstitial nephritis in kidney allograft</atitle><jtitle>Transplant infectious disease</jtitle><addtitle>Transpl Infect Dis</addtitle><date>2012-06</date><risdate>2012</risdate><volume>14</volume><issue>3</issue><spage>288</spage><epage>291</epage><pages>288-291</pages><issn>1398-2273</issn><eissn>1399-3062</eissn><abstract>Giant cell tubulointerstitial nephritis in the kidney allograft caused by infection is rare, and donor‐transmitted infection in transplanted kidneys is also rare. In this case report, we describe an unusual histological manifestation of Candida albicans in the graft biopsy of a 53‐year‐old male kidney transplant recipient with decreased renal function 12 days post transplant. Several giant cells were present in the tubulointerstitial inflammation, as well as yeasts, with no evidence of rejection, and the histological diagnosis was confirmed by urine culture. Donor urine culture was positive for C. albicans, suggestive of a possible donor‐transmitted infection. Prompt antifungal treatment eradicated the infection, and averted systemic spread. To our knowledge, there are no previous reports of Candida infection with giant cell tubulointerstitial nephritis in human renal allograft.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>22093412</pmid><doi>10.1111/j.1399-3062.2011.00676.x</doi><tpages>4</tpages></addata></record> |
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| subjects | Antifungal Agents - therapeutic use biopsy Candida Candida albicans - isolation & purification Candidiasis - drug therapy Candidiasis - microbiology donor-transmitted giant cell Humans kidney transplant Kidney Transplantation Male Middle Aged Nephritis, Interstitial - drug therapy Nephritis, Interstitial - microbiology Tissue Donors Transplantation, Homologous Treatment Outcome Urine - microbiology |
| title | Fungal infection presenting as giant cell tubulointerstitial nephritis in kidney allograft |
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