Unraveling the influence of endothelial cell density on VEGF-A signaling

Vascular endothelial growth factor-A (VEGF) is the master determinant for the activation of the angiogenic program leading to the formation of new blood vessels to sustain solid tumor growth and metastasis. VEGF specific binding to VEGF receptor-2 (VEGFR-2) triggers different signaling pathways, inc...

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Veröffentlicht in:	Blood 2012-06, Vol.119 (23), p.5599-5607
Hauptverfasser:	Napione, Lucia, Pavan, Simona, Veglio, Andrea, Picco, Andrea, Boffetta, Guido, Celani, Antonio, Seano, Giorgio, Primo, Luca, Gamba, Andrea, Bussolino, Federico
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Count Endothelial Cells - cytology Endothelial Cells - metabolism Hematologic and hematopoietic diseases Human Umbilical Vein Endothelial Cells Humans Medical sciences Models, Biological Protein Tyrosine Phosphatases - metabolism Signal Transduction Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-2 - metabolism
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