Subchronic Hepatotoxicity Evaluation of 1,2,4-Tribromobenzene in Sprague-Dawley Rats

Male Sprague-Dawley rats were exposed to 1,2,4-tribromobenzene (TBB) by gavage for 5 days, 2, 4, and 13 weeks at 0, 2.5, 5, 10, 25, or 75 mg/kg per d. There were no TBB exposure-related clinical signs of toxicity or changes in body weight. Liver weight increases were dose and exposure time related a...

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Veröffentlicht in:	International journal of toxicology 2012-06, Vol.31 (3), p.250-256
Hauptverfasser:	Dodd, Darol E., Pluta, Linda J., Sochaski, Mark A., Funk, Kathleen A., Thomas, Russell S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bromobenzenes - blood Bromobenzenes - pharmacokinetics Bromobenzenes - toxicity Liver - drug effects Liver - pathology Male No-Observed-Adverse-Effect Level Organ Size - drug effects Rats Rats, Sprague-Dawley Toxicity Tests, Subchronic
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