Key challenges to the development of extracorporeal bioartificial liver support systems
BACKGROUND: For nearly three decades, extracorporeal bioartificial liver (BAL) support systems have been anticipated as promising tools for the treatment of liver failure. However, these systems are still far from clinical application. This review aimed to analyze the key challenges to the developme...
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| Veröffentlicht in: | Hepatobiliary & pancreatic diseases international 2012-06, Vol.11 (3), p.243-249 |
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| creator | Zhao, Li-Fu Pan, Xiao-Ping Li, Lan-Juan |
| description | BACKGROUND: For nearly three decades, extracorporeal bioartificial liver (BAL) support systems have been anticipated as promising tools for the treatment of liver failure. However, these systems are still far from clinical application. This review aimed to analyze the key challenges to the development of BALs. DATA SOURCE: We carried out a PubMed search of Englishlanguage articles relevant to extracorporeal BAL support systems and liver failure. RESULTS: Extracorporeal BALs face a series of challenges. First, an appropriate cell source for BAL is not readily available. Second, existing bioreactors do not provide in vivolike oxygenation and bile secretion. Third, emergency needs cannot be met by current BALs. Finally, the effectiveness of BALs, either in animals or in patients, has been difficult to document. CONCLUSIONS: Extracorporeal BAL support systems are mainly challenged by incompetent cell sources and flawed bioreactors. To advance this technology, future research is needed to provide more insights into interpreting the conditions for hepatocyte differentiation and liver microstructure formation. |
| doi_str_mv | 10.1016/S1499-3872(12)60155-6 |
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However, these systems are still far from clinical application. This review aimed to analyze the key challenges to the development of BALs. DATA SOURCE: We carried out a PubMed search of Englishlanguage articles relevant to extracorporeal BAL support systems and liver failure. RESULTS: Extracorporeal BALs face a series of challenges. First, an appropriate cell source for BAL is not readily available. Second, existing bioreactors do not provide in vivolike oxygenation and bile secretion. Third, emergency needs cannot be met by current BALs. Finally, the effectiveness of BALs, either in animals or in patients, has been difficult to document. CONCLUSIONS: Extracorporeal BAL support systems are mainly challenged by incompetent cell sources and flawed bioreactors. To advance this technology, future research is needed to provide more insights into interpreting the conditions for hepatocyte differentiation and liver microstructure formation.</description><identifier>ISSN: 1499-3872</identifier><identifier>DOI: 10.1016/S1499-3872(12)60155-6</identifier><identifier>PMID: 22672816</identifier><language>eng</language><publisher>Singapore: Elsevier B.V</publisher><subject>Animals ; bioartificial ; bioartificial liver ; bioreactor ; Bioreactors ; cell ; Cell Differentiation ; cell source ; Cells, Cultured ; Endocrinology & Metabolism ; Equipment Design ; failure ; Gastroenterology and Hepatology ; Hepatocytes - metabolism ; Hepatocytes - pathology ; Hepatocytes - transplantation ; Humans ; liver ; Liver - metabolism ; Liver - pathology ; Liver - surgery ; liver failure ; Liver Failure - metabolism ; Liver Failure - pathology ; Liver Failure - surgery ; Liver, Artificial - adverse effects ; source ; Treatment Outcome</subject><ispartof>Hepatobiliary & pancreatic diseases international, 2012-06, Vol.11 (3), p.243-249</ispartof><rights>The Editorial Board of Hepatobiliary & Pancreatic Diseases International</rights><rights>2012 The Editorial Board of Hepatobiliary & Pancreatic Diseases International</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-fd507c85b673f59e49e6b81ce6383f95d8ee2064ef745b85b4d1f5b26d504bcd3</citedby><cites>FETCH-LOGICAL-c448t-fd507c85b673f59e49e6b81ce6383f95d8ee2064ef745b85b4d1f5b26d504bcd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/89801X/89801X.jpg</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1499387212601556$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22672816$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Li-Fu</creatorcontrib><creatorcontrib>Pan, Xiao-Ping</creatorcontrib><creatorcontrib>Li, Lan-Juan</creatorcontrib><title>Key challenges to the development of extracorporeal bioartificial liver support systems</title><title>Hepatobiliary & pancreatic diseases international</title><addtitle>Hepatobiliary & Pancreatic Diseases International</addtitle><description>BACKGROUND: For nearly three decades, extracorporeal bioartificial liver (BAL) support systems have been anticipated as promising tools for the treatment of liver failure. However, these systems are still far from clinical application. This review aimed to analyze the key challenges to the development of BALs. DATA SOURCE: We carried out a PubMed search of Englishlanguage articles relevant to extracorporeal BAL support systems and liver failure. RESULTS: Extracorporeal BALs face a series of challenges. First, an appropriate cell source for BAL is not readily available. Second, existing bioreactors do not provide in vivolike oxygenation and bile secretion. Third, emergency needs cannot be met by current BALs. Finally, the effectiveness of BALs, either in animals or in patients, has been difficult to document. CONCLUSIONS: Extracorporeal BAL support systems are mainly challenged by incompetent cell sources and flawed bioreactors. To advance this technology, future research is needed to provide more insights into interpreting the conditions for hepatocyte differentiation and liver microstructure formation.</description><subject>Animals</subject><subject>bioartificial</subject><subject>bioartificial liver</subject><subject>bioreactor</subject><subject>Bioreactors</subject><subject>cell</subject><subject>Cell Differentiation</subject><subject>cell source</subject><subject>Cells, Cultured</subject><subject>Endocrinology & Metabolism</subject><subject>Equipment Design</subject><subject>failure</subject><subject>Gastroenterology and Hepatology</subject><subject>Hepatocytes - metabolism</subject><subject>Hepatocytes - pathology</subject><subject>Hepatocytes - transplantation</subject><subject>Humans</subject><subject>liver</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Liver - surgery</subject><subject>liver failure</subject><subject>Liver Failure - metabolism</subject><subject>Liver Failure - pathology</subject><subject>Liver Failure - surgery</subject><subject>Liver, Artificial - adverse effects</subject><subject>source</subject><subject>Treatment Outcome</subject><issn>1499-3872</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1vFSEUhllo2lr9CRoSN3UxCgwwzEbTNH7FJl1U45LMMId7qcwwBebG--_lftgYN10R4Dnvyfsg9JKSt5RQ-e6W8ratatWwC8reSEKFqOQTdPbwfIqepXRHCFNKyBN0yphsmKLyDP38Blts1p33MK0g4RxwXgMeYAM-zCNMGQeL4XeOnQlxDhE6j3sXupiddcaVm3cbiDgtc_nNOG1ThjE9R09t5xO8OJ7n6Menj9-vvlTXN5-_Xl1eV4ZzlSs7CNIYJXrZ1Fa0wFuQvaIGZK1q24pBATAiOdiGi75wfKBW9EyWOd6boT5HF4fcOYb7BVLWo0sGvO8mCEvSxU8raSNrXlBxQE0MKUWweo5u7OK2QDtO6r1HvROmKdN7j1qWuVfHFUs_wvAw9VdiAT4cAChFNw6iTsbBZGBwEUzWQ3CPrnj_X4LxbnKm879gC-kuLHEqFjXViWlyCNllULZP2AW8PnZbh2l176bVP-VITWrWElH_ASeJpl4</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Zhao, Li-Fu</creator><creator>Pan, Xiao-Ping</creator><creator>Li, Lan-Juan</creator><general>Elsevier B.V</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120601</creationdate><title>Key challenges to the development of extracorporeal bioartificial liver support systems</title><author>Zhao, Li-Fu ; Pan, Xiao-Ping ; Li, Lan-Juan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-fd507c85b673f59e49e6b81ce6383f95d8ee2064ef745b85b4d1f5b26d504bcd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>bioartificial</topic><topic>bioartificial liver</topic><topic>bioreactor</topic><topic>Bioreactors</topic><topic>cell</topic><topic>Cell Differentiation</topic><topic>cell source</topic><topic>Cells, Cultured</topic><topic>Endocrinology & Metabolism</topic><topic>Equipment Design</topic><topic>failure</topic><topic>Gastroenterology and Hepatology</topic><topic>Hepatocytes - metabolism</topic><topic>Hepatocytes - pathology</topic><topic>Hepatocytes - transplantation</topic><topic>Humans</topic><topic>liver</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Liver - surgery</topic><topic>liver failure</topic><topic>Liver Failure - metabolism</topic><topic>Liver Failure - pathology</topic><topic>Liver Failure - surgery</topic><topic>Liver, Artificial - adverse effects</topic><topic>source</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Li-Fu</creatorcontrib><creatorcontrib>Pan, Xiao-Ping</creatorcontrib><creatorcontrib>Li, Lan-Juan</creatorcontrib><collection>维普_期刊</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>维普中文期刊数据库</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hepatobiliary & pancreatic diseases international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Li-Fu</au><au>Pan, Xiao-Ping</au><au>Li, Lan-Juan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Key challenges to the development of extracorporeal bioartificial liver support systems</atitle><jtitle>Hepatobiliary & pancreatic diseases international</jtitle><addtitle>Hepatobiliary & Pancreatic Diseases International</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>11</volume><issue>3</issue><spage>243</spage><epage>249</epage><pages>243-249</pages><issn>1499-3872</issn><abstract>BACKGROUND: For nearly three decades, extracorporeal bioartificial liver (BAL) support systems have been anticipated as promising tools for the treatment of liver failure. However, these systems are still far from clinical application. This review aimed to analyze the key challenges to the development of BALs. DATA SOURCE: We carried out a PubMed search of Englishlanguage articles relevant to extracorporeal BAL support systems and liver failure. RESULTS: Extracorporeal BALs face a series of challenges. First, an appropriate cell source for BAL is not readily available. Second, existing bioreactors do not provide in vivolike oxygenation and bile secretion. Third, emergency needs cannot be met by current BALs. Finally, the effectiveness of BALs, either in animals or in patients, has been difficult to document. CONCLUSIONS: Extracorporeal BAL support systems are mainly challenged by incompetent cell sources and flawed bioreactors. To advance this technology, future research is needed to provide more insights into interpreting the conditions for hepatocyte differentiation and liver microstructure formation.</abstract><cop>Singapore</cop><pub>Elsevier B.V</pub><pmid>22672816</pmid><doi>10.1016/S1499-3872(12)60155-6</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals bioartificial bioartificial liver bioreactor Bioreactors cell Cell Differentiation cell source Cells, Cultured Endocrinology & Metabolism Equipment Design failure Gastroenterology and Hepatology Hepatocytes - metabolism Hepatocytes - pathology Hepatocytes - transplantation Humans liver Liver - metabolism Liver - pathology Liver - surgery liver failure Liver Failure - metabolism Liver Failure - pathology Liver Failure - surgery Liver, Artificial - adverse effects source Treatment Outcome |
| title | Key challenges to the development of extracorporeal bioartificial liver support systems |
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