Ubiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III phosphatidylinositol 3-kinase activity and tumor suppression

The class III phosphatidylinositol 3-kinase (PI3K-III) complex and its phosphorylated lipid product phosphatidylinositol 3-phosphate (PtdIns3P) control the three topologically related membrane-involution processes autophagy, endocytosis, and cytokinesis. The activity of the catalytic unit of PI3K-II...

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Veröffentlicht in:	FEBS letters 2012-06, Vol.586 (11), p.1584-1591
Hauptverfasser:	Abrahamsen, Hilde, Stenmark, Harald, Platta, Harald W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Regulatory Proteins - metabolism BCL-2 Beclin 1 Cancer Class III Phosphatidylinositol 3-Kinases - metabolism Genes, Tumor Suppressor Humans Membrane Proteins - metabolism NEDD4 Neoplasms - enzymology Neoplasms - metabolism Neoplasms - pathology Phosphatidylinositol 3-kinase (PI3K) Phosphatidylinositol 3-Kinase - metabolism Phosphorylation TRAF6 Ubiquitin-protein ligase (E3) Ubiquitination VPS15 VPS34
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