Peak Expiratory Flow Rate Shows a Gender-Specific Association with Vitamin D Deficiency
Context: To our knowledge, no previous studies examined the longitudinal relationship between vitamin D status and pulmonary function in a population-based sample of older persons. Objective: Our objective was to examine the cross-sectional as well as the longitudinal relationship between vitamin D...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2012-06, Vol.97 (6), p.2164-2171 |
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| container_title | The journal of clinical endocrinology and metabolism |
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| creator | van Schoor, N. M de Jongh, R. T Daniels, J. M. A Heymans, M. W Deeg, D. J. H Lips, P |
| description | Context:
To our knowledge, no previous studies examined the longitudinal relationship between vitamin D status and pulmonary function in a population-based sample of older persons.
Objective:
Our objective was to examine the cross-sectional as well as the longitudinal relationship between vitamin D status and peak expiratory flow rate (PEFR) in a representative sample of the Dutch older population.
Design, Setting, and Participants:
Participants included men and women in the Longitudinal Aging Study Amsterdam, an ongoing cohort study in older people.
Main Outcome Measure:
PEFR was measured using the mini-Wright peak flow meter.
Results:
Men with serum 25-hydroxyvitamin D (25-OHD) levels below 10 ng/ml (25 nmol/liter) had a significantly lower PEFR in the cross-sectional analyses, and men with serum 25-OHD levels below 20 ng/ml (50 nmol/liter) had a significantly lower PEFR in the longitudinal analyses as compared with men with serum 25-OHD levels above 30 ng/ml (75 nmol/liter) (cross-sectional: β = −47.0, P = 0.01 for serum 25-OHD |
| doi_str_mv | 10.1210/jc.2011-3199 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1019615318</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1019615318</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4486-d2b3516df3ecd41b724f9995a1274ca28140b1f1bdaac3d902fa7734929e51b3</originalsourceid><addsrcrecordid>eNpt0M1v0zAYB2ALgVgZ3DgjX5A44M2v48T1cdoXSJOY2ATcLMd5o7pL48xOFPrfz10LXPDFsvW8H_oR8h74CQjgp2t3IjgAK0DrF2QBWpZMgVYvyYJzAUwr8euIvElpzTlIWRavyZEQUomyqhbk5y3aB3r5e_DRjiFu6VUXZvrdjkjvVmFO1NJr7BuM7G5A51vv6FlKwXk7-tDT2Y8r-sOPduN7ekEvMAOPvdu-Ja9a2yV8d7iPyf3V5f35F3bz7frr-dkNc1IuK9aIuiihatoCXSOhVkK2WuvSglDSWbEEyWtooW6sdUWjuWitUoXUQmMJdXFMPu3bDjE8TphGs_HJYdfZHsOUDHDQFZQFLDP9vKcuhpQitmaIfmPjNiOzS9KsndklaXZJZv7h0HmqN9j8xX-iy-DjAdjkbNdG2zuf_rlSVypPzk7u3Ry6EWN66KYZo1mh7caV4fnISi1Znix4lV_s-SeXFfuynH5w0fc4REzJrMMU-5zo_7d-Ajvmmv4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1019615318</pqid></control><display><type>article</type><title>Peak Expiratory Flow Rate Shows a Gender-Specific Association with Vitamin D Deficiency</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><source>Journals@Ovid Complete</source><creator>van Schoor, N. M ; de Jongh, R. T ; Daniels, J. M. A ; Heymans, M. W ; Deeg, D. J. H ; Lips, P</creator><creatorcontrib>van Schoor, N. M ; de Jongh, R. T ; Daniels, J. M. A ; Heymans, M. W ; Deeg, D. J. H ; Lips, P</creatorcontrib><description>Context:
To our knowledge, no previous studies examined the longitudinal relationship between vitamin D status and pulmonary function in a population-based sample of older persons.
Objective:
Our objective was to examine the cross-sectional as well as the longitudinal relationship between vitamin D status and peak expiratory flow rate (PEFR) in a representative sample of the Dutch older population.
Design, Setting, and Participants:
Participants included men and women in the Longitudinal Aging Study Amsterdam, an ongoing cohort study in older people.
Main Outcome Measure:
PEFR was measured using the mini-Wright peak flow meter.
Results:
Men with serum 25-hydroxyvitamin D (25-OHD) levels below 10 ng/ml (25 nmol/liter) had a significantly lower PEFR in the cross-sectional analyses, and men with serum 25-OHD levels below 20 ng/ml (50 nmol/liter) had a significantly lower PEFR in the longitudinal analyses as compared with men with serum 25-OHD levels above 30 ng/ml (75 nmol/liter) (cross-sectional: β = −47.0, P = 0.01 for serum 25-OHD <10 ng/ml; longitudinal: β = −45.0, P < 0.01 for serum 25-OHD <10 ng/ml; and β = −20.2, P = 0.03 for serum 25-OHD = 10–20 ng/ml in the fully adjusted models). Physical performance (β = −32.5, P = 0.08 for serum 25-OHD <10 ng/ml) and grip strength (β = −40.0, P = 0.03 for serum 25-OHD <10 ng/ml) partly mediated the cross-sectional associations but not the longitudinal associations. In women, statistically significant associations between 25-OHD and PEFR were observed in the cross-sectional analyses after adjustment for age and season of blood collection but not in the fully adjusted models or in the longitudinal analyses.
Conclusions:
A strong relationship between serum 25-OHD and PEFR was observed in older men, both in the cross-sectional as well as longitudinal analyses, but not in older women. The association in men could partly be explained by physical performance and muscle strength.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2011-3199</identifier><identifier>PMID: 22472566</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Aged ; Aged, 80 and over ; Aging - physiology ; Biological and medical sciences ; Cohort Studies ; Cross-Sectional Studies ; Endocrinopathies ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Longitudinal Studies ; Male ; Medical sciences ; Peak Expiratory Flow Rate - physiology ; Physical Fitness - physiology ; Sex Characteristics ; Sex Distribution ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D Deficiency - epidemiology ; Vitamin D Deficiency - physiopathology</subject><ispartof>The journal of clinical endocrinology and metabolism, 2012-06, Vol.97 (6), p.2164-2171</ispartof><rights>Copyright © 2012 by The Endocrine Society</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4486-d2b3516df3ecd41b724f9995a1274ca28140b1f1bdaac3d902fa7734929e51b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25967153$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22472566$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Schoor, N. M</creatorcontrib><creatorcontrib>de Jongh, R. T</creatorcontrib><creatorcontrib>Daniels, J. M. A</creatorcontrib><creatorcontrib>Heymans, M. W</creatorcontrib><creatorcontrib>Deeg, D. J. H</creatorcontrib><creatorcontrib>Lips, P</creatorcontrib><title>Peak Expiratory Flow Rate Shows a Gender-Specific Association with Vitamin D Deficiency</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Context:
To our knowledge, no previous studies examined the longitudinal relationship between vitamin D status and pulmonary function in a population-based sample of older persons.
Objective:
Our objective was to examine the cross-sectional as well as the longitudinal relationship between vitamin D status and peak expiratory flow rate (PEFR) in a representative sample of the Dutch older population.
Design, Setting, and Participants:
Participants included men and women in the Longitudinal Aging Study Amsterdam, an ongoing cohort study in older people.
Main Outcome Measure:
PEFR was measured using the mini-Wright peak flow meter.
Results:
Men with serum 25-hydroxyvitamin D (25-OHD) levels below 10 ng/ml (25 nmol/liter) had a significantly lower PEFR in the cross-sectional analyses, and men with serum 25-OHD levels below 20 ng/ml (50 nmol/liter) had a significantly lower PEFR in the longitudinal analyses as compared with men with serum 25-OHD levels above 30 ng/ml (75 nmol/liter) (cross-sectional: β = −47.0, P = 0.01 for serum 25-OHD <10 ng/ml; longitudinal: β = −45.0, P < 0.01 for serum 25-OHD <10 ng/ml; and β = −20.2, P = 0.03 for serum 25-OHD = 10–20 ng/ml in the fully adjusted models). Physical performance (β = −32.5, P = 0.08 for serum 25-OHD <10 ng/ml) and grip strength (β = −40.0, P = 0.03 for serum 25-OHD <10 ng/ml) partly mediated the cross-sectional associations but not the longitudinal associations. In women, statistically significant associations between 25-OHD and PEFR were observed in the cross-sectional analyses after adjustment for age and season of blood collection but not in the fully adjusted models or in the longitudinal analyses.
Conclusions:
A strong relationship between serum 25-OHD and PEFR was observed in older men, both in the cross-sectional as well as longitudinal analyses, but not in older women. The association in men could partly be explained by physical performance and muscle strength.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - physiology</subject><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Endocrinopathies</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Peak Expiratory Flow Rate - physiology</subject><subject>Physical Fitness - physiology</subject><subject>Sex Characteristics</subject><subject>Sex Distribution</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vertebrates: endocrinology</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Vitamin D Deficiency - epidemiology</subject><subject>Vitamin D Deficiency - physiopathology</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0M1v0zAYB2ALgVgZ3DgjX5A44M2v48T1cdoXSJOY2ATcLMd5o7pL48xOFPrfz10LXPDFsvW8H_oR8h74CQjgp2t3IjgAK0DrF2QBWpZMgVYvyYJzAUwr8euIvElpzTlIWRavyZEQUomyqhbk5y3aB3r5e_DRjiFu6VUXZvrdjkjvVmFO1NJr7BuM7G5A51vv6FlKwXk7-tDT2Y8r-sOPduN7ekEvMAOPvdu-Ja9a2yV8d7iPyf3V5f35F3bz7frr-dkNc1IuK9aIuiihatoCXSOhVkK2WuvSglDSWbEEyWtooW6sdUWjuWitUoXUQmMJdXFMPu3bDjE8TphGs_HJYdfZHsOUDHDQFZQFLDP9vKcuhpQitmaIfmPjNiOzS9KsndklaXZJZv7h0HmqN9j8xX-iy-DjAdjkbNdG2zuf_rlSVypPzk7u3Ry6EWN66KYZo1mh7caV4fnISi1Znix4lV_s-SeXFfuynH5w0fc4REzJrMMU-5zo_7d-Ajvmmv4</recordid><startdate>201206</startdate><enddate>201206</enddate><creator>van Schoor, N. M</creator><creator>de Jongh, R. T</creator><creator>Daniels, J. M. A</creator><creator>Heymans, M. W</creator><creator>Deeg, D. J. H</creator><creator>Lips, P</creator><general>Endocrine Society</general><general>Copyright by The Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201206</creationdate><title>Peak Expiratory Flow Rate Shows a Gender-Specific Association with Vitamin D Deficiency</title><author>van Schoor, N. M ; de Jongh, R. T ; Daniels, J. M. A ; Heymans, M. W ; Deeg, D. J. H ; Lips, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4486-d2b3516df3ecd41b724f9995a1274ca28140b1f1bdaac3d902fa7734929e51b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - physiology</topic><topic>Biological and medical sciences</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Endocrinopathies</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Peak Expiratory Flow Rate - physiology</topic><topic>Physical Fitness - physiology</topic><topic>Sex Characteristics</topic><topic>Sex Distribution</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vertebrates: endocrinology</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>Vitamin D Deficiency - epidemiology</topic><topic>Vitamin D Deficiency - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Schoor, N. M</creatorcontrib><creatorcontrib>de Jongh, R. T</creatorcontrib><creatorcontrib>Daniels, J. M. A</creatorcontrib><creatorcontrib>Heymans, M. W</creatorcontrib><creatorcontrib>Deeg, D. J. H</creatorcontrib><creatorcontrib>Lips, P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Schoor, N. M</au><au>de Jongh, R. T</au><au>Daniels, J. M. A</au><au>Heymans, M. W</au><au>Deeg, D. J. H</au><au>Lips, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peak Expiratory Flow Rate Shows a Gender-Specific Association with Vitamin D Deficiency</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2012-06</date><risdate>2012</risdate><volume>97</volume><issue>6</issue><spage>2164</spage><epage>2171</epage><pages>2164-2171</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>Context:
To our knowledge, no previous studies examined the longitudinal relationship between vitamin D status and pulmonary function in a population-based sample of older persons.
Objective:
Our objective was to examine the cross-sectional as well as the longitudinal relationship between vitamin D status and peak expiratory flow rate (PEFR) in a representative sample of the Dutch older population.
Design, Setting, and Participants:
Participants included men and women in the Longitudinal Aging Study Amsterdam, an ongoing cohort study in older people.
Main Outcome Measure:
PEFR was measured using the mini-Wright peak flow meter.
Results:
Men with serum 25-hydroxyvitamin D (25-OHD) levels below 10 ng/ml (25 nmol/liter) had a significantly lower PEFR in the cross-sectional analyses, and men with serum 25-OHD levels below 20 ng/ml (50 nmol/liter) had a significantly lower PEFR in the longitudinal analyses as compared with men with serum 25-OHD levels above 30 ng/ml (75 nmol/liter) (cross-sectional: β = −47.0, P = 0.01 for serum 25-OHD <10 ng/ml; longitudinal: β = −45.0, P < 0.01 for serum 25-OHD <10 ng/ml; and β = −20.2, P = 0.03 for serum 25-OHD = 10–20 ng/ml in the fully adjusted models). Physical performance (β = −32.5, P = 0.08 for serum 25-OHD <10 ng/ml) and grip strength (β = −40.0, P = 0.03 for serum 25-OHD <10 ng/ml) partly mediated the cross-sectional associations but not the longitudinal associations. In women, statistically significant associations between 25-OHD and PEFR were observed in the cross-sectional analyses after adjustment for age and season of blood collection but not in the fully adjusted models or in the longitudinal analyses.
Conclusions:
A strong relationship between serum 25-OHD and PEFR was observed in older men, both in the cross-sectional as well as longitudinal analyses, but not in older women. The association in men could partly be explained by physical performance and muscle strength.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>22472566</pmid><doi>10.1210/jc.2011-3199</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-972X |
| ispartof | The journal of clinical endocrinology and metabolism, 2012-06, Vol.97 (6), p.2164-2171 |
| issn | 0021-972X 1945-7197 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1019615318 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Aged Aged, 80 and over Aging - physiology Biological and medical sciences Cohort Studies Cross-Sectional Studies Endocrinopathies Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Humans Longitudinal Studies Male Medical sciences Peak Expiratory Flow Rate - physiology Physical Fitness - physiology Sex Characteristics Sex Distribution Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - epidemiology Vitamin D Deficiency - physiopathology |
| title | Peak Expiratory Flow Rate Shows a Gender-Specific Association with Vitamin D Deficiency |
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