The 312N variant of the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) confers up to 2·7-fold increased risk of polycystic ovary syndrome in a Sardinian population

Summary Objective Polycystic ovary syndrome (PCOS) is a frequent condition, affecting about 15% of women of reproductive age. Because of its familial occurrence, a multifactorial model of susceptibility, including both genetic and environmental factors, has been proposed. However, the identification...

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Veröffentlicht in:	Clinical endocrinology (Oxford) 2012-07, Vol.77 (1), p.113-119
Hauptverfasser:	Capalbo, A., Sagnella, F., Apa, R., Fulghesu, A. M., Lanzone, A., Morciano, A., Farcomeni, A., Gangale, M. F., Moro, F., Martinez, D., Ciardulli, A., Palla, C., Uras, M. L., Spettu, F., Cappai, A., Carcassi, C., Neri, G., Tiziano, F. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Alleles Biological and medical sciences Case-Control Studies Endocrinopathies Female Female genital diseases Fundamental and applied biological sciences. Psychology Gene Frequency Genetic Predisposition to Disease Genetics, Population Genotype & phenotype Gynecology. Andrology. Obstetrics Humans Italy - epidemiology Medical sciences Non tumoral diseases Polycystic ovary syndrome Polycystic Ovary Syndrome - epidemiology Polycystic Ovary Syndrome - genetics Polymorphism, Single Nucleotide - physiology Receptors, LH - genetics Risk Factors Vertebrates: endocrinology Women Young Adult
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