miR-495 and miR-551a inhibit the migration and invasion of human gastric cancer cells by directly interacting with PRL - 3

The phosphatase of regenerating liver-3 (PRL-3) gene is associated with metastasis in gastric cancer, and is believed to play a causative role by promoting tumor cell motility, invasion, and metastasis, but little is known of the mechanisms involved. We previously reported that PRL-3 expression is s...

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Veröffentlicht in:	Cancer letters 2012-10, Vol.323 (1), p.41-47
Hauptverfasser:	Li, Zhengrong, Cao, Yi, Jie, Zhigang, Liu, Yi, Li, Yingliang, Li, Junhe, Zhu, Guoming, Liu, Zhengren, Tu, Yi, Peng, Gen, Lee, Dong-woo, Park, Sung-soo
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Binding sites Blotting, Western Breast cancer Carcinoma Cell migration cell movement Cell Movement - genetics Colorectal cancer Down-Regulation Gastric cancer Gastric carcinoma Gc gene Gene expression gene overexpression Gene therapy Hematology, Oncology and Palliative Medicine Humans Metastases metastasis microRNA MicroRNAs - genetics MicroRNAs - metabolism miR-495 miR-551a miRNA Motility mRNA Neoplasm Invasiveness Neoplasm Proteins - metabolism oncogenes Peritoneum PRL-3 Protein Tyrosine Phosphatases - metabolism Proteins quantitative polymerase chain reaction Real-Time Polymerase Chain Reaction Rodents stomach neoplasms Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Transfection Tumorigenesis Tumors Western blotting
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