Vildagliptin added to metformin on β-cell function after a euglycemic hyperinsulinemic and hyperglycemic clamp in type 2 diabetes patients

This study evaluated the effect of vildagliptin + metformin on glycemic control and β-cell function in type 2 diabetes patients. One hundred seventy-one type 2 diabetes patients, naive to antidiabetes therapy and with poor glycemic control, were instructed to take metformin for 8±2 months up to a me...

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Veröffentlicht in:	Diabetes technology & therapeutics 2012-06, Vol.14 (6), p.475-484
Hauptverfasser:	Derosa, Giuseppe, Ragonesi, Pietro D, Carbone, Anna, Fogari, Elena, Bianchi, Lucio, Bonaventura, Aldo, Romano, Davide, Cicero, Arrigo F G, Maffioli, Pamela
Format:	Artikel
Sprache:	eng
Schlagworte:	Adamantane - administration & dosage Adamantane - analogs & derivatives Adamantane - pharmacology Blood Glucose - metabolism Body Mass Index C-Peptide - blood Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Drug Therapy, Combination Fasting - blood Female Glucose Clamp Technique - methods Humans Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - pharmacology Insulin - metabolism Insulin Resistance Insulin Secretion Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Male Metformin - administration & dosage Metformin - pharmacology Middle Aged Nitriles - administration & dosage Nitriles - pharmacology Pyrrolidines - administration & dosage Pyrrolidines - pharmacology Vildagliptin Weight Loss - drug effects
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