Bone, microenvironment and hematopoiesis

PURPOSE OF REVIEWHematopoietic stem cells (HSCs) mature to form all blood cells and the study into how HSC fate decisions are made has exploded in recent years. In an effort to fully understand the function and organization of HSCs and hematopoietic progenitor cells (HPCs), many groups have identified the microenvironment in which they reside as playing a key role. This review highlights the findings within the last 18 months on the cells and molecules shown to be important within the bone marrow HSC niche for HSC regulation. RECENT FINDINGSPrevious research has heavily concentrated on the role of osteoblasts, mesenchymal stem cells (MSCs), reticular stromal cells, endothelial cells and nerve cells. More recently, research has not only expanded on the role of these cells, but has also shown that mature hematopoietic cells such as macrophages and megakaryocytes are also important in the maintenance of hematopoiesis within the HSC niche. SUMMARYIdentifying and understanding the roles of all cells comprising the HSC niche coupled with the development of better 3D imaging and 3D in-vitro mimicking of the HSC niche will increase our understanding of where HSCs reside and how they are regulated. Research will lead to better manipulation of HSCs for mobilization, homing and hematopoietic reconstitution following injury or disease.