The diagnostic accuracy of two human epididymis protein 4 (HE4) testing systems in combination with CA125 in the differential diagnosis of ovarian masses

Background: Cancer antigen 125 (CA125) is the best known single tumor marker for ovarian cancer (OC). We investigated whether the additional information of the human epididymis protein 4 (HE4) improves diagnostic accuracy. Methods: We retrospectively analyzed preoperative sera of 109 healthy women,...

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Veröffentlicht in:	Clinical chemistry and laboratory medicine 2011-12, Vol.49 (12), p.2081-2088
Hauptverfasser:	Lenhard, Miriam, Stieber, Petra, Hertlein, Linda, Kirschenhofer, Angela, Fürst, Sophie, Mayr, Doris, Nagel, Dorothea, Hofmann, Karin, Krocker, Katja, Burges, Alexander
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Area Under Curve Biological and medical sciences Biomarkers, Tumor - blood CA-125 Antigen - blood CA125 Diagnosis, Differential Epididymal Secretory Proteins - analysis Female Female genital diseases General aspects Gynecology. Andrology. Obstetrics human epididymis protein 4 (HE4) Humans Immunoassay Investigative techniques, diagnostic techniques (general aspects) Medical sciences Middle Aged ovarian cancer Ovarian Neoplasms - diagnosis Retrospective Studies Risk Factors risk of malignancy algorithm (ROMA) ROC Curve Sensitivity and Specificity tumor marker Tumors Young Adult
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